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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: GRB2

Summary

GeneID

2885

Symbol

GRB2

Synonyms

ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084

Description

growth factor receptor-bound protein 2

Locus tag

Gene type

protein-coding

Map location

17q24-q25

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 17.4417

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PTPRN

0.96

PRRT3

0.94

0.92

RASGRF1

0.93

0.89

SLC12A5

0.93

0.95

TRPM2

0.93

0.86

KCNJ9

0.93

0.90

DNM1

0.92

0.94

CLSTN1

0.92

0.89

CNNM1

0.92

NPTN

0.92

Top 10 negatively co-expressed genes

C9orf46

-0.47

-0.45

C21orf57

-0.47

-0.43

BCL7C

-0.47

-0.50

RAB13

-0.46

-0.54

RPS20

-0.46

-0.53

GTF3C6

-0.45

-0.41

RPS6

-0.44

RPL23A

-0.43

-0.46

RPS23

-0.43

-0.39

RPL24

-0.43

-0.41

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005154

epidermal growth factor receptor binding

IPI

12577067

GO:0005070

SH3/SH2 adaptor activity

TAS

8253073

GO:0043560

insulin receptor substrate binding

IPI

8388384

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007173

epidermal growth factor receptor signaling pathway

TAS

1322798

GO:0007267

cell-cell signaling

TAS

8253073

GO:0007265

Ras protein signal transduction

EXP

11520933

GO:0007265

Ras protein signal transduction

TAS

8253073

GO:0008286

insulin receptor signaling pathway

IPI

8388384

GO:0044419

interspecies interaction between organisms

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005794

Golgi apparatus

IEA

GO:0005829

cytosol

EXP

7739560 |8479541 |8493579
|8621719 |8810325
|9356464 |9690470
|10567358 |10648629
|10734310 |10913131
|11606067

GO:0005829

cytosol

TAS

14722116

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD	9516488
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Affinity Capture-Western	BioGRID	9407116
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	Affinity Capture-MS	BioGRID	12577067
ADA	-	adenosine deaminase	-	HPRD	9299436
ADAM10	AD10 \| CD156c \| HsT18717 \| MADM \| kuz	ADAM metallopeptidase domain 10	Affinity Capture-Western	BioGRID	11741929
ADAM12	MCMP \| MCMPMltna \| MLTN \| MLTNA	ADAM metallopeptidase domain 12	-	HPRD	11127814
ADAM15	MDC15	ADAM metallopeptidase domain 15	-	HPRD,BioGRID	11741929
ADRB1	ADRB1R \| B1AR \| BETA1AR \| RHR	adrenergic, beta-1-, receptor	beta-1-AR interacts with Grb2.	BIND	9843378
ADRB2	ADRB2R \| ADRBR \| B2AR \| BAR \| BETA2AR	adrenergic, beta-2-, receptor, surface	-	HPRD,BioGRID	9830057
ALOX5	5-LO \| 5-LOX \| 5LPG \| LOG5 \| MGC163204	arachidonate 5-lipoxygenase	-	HPRD,BioGRID	7929073 \|8585605
ANXA2	ANX2 \| ANX2L4 \| CAL1H \| LIP2 \| LPC2 \| LPC2D \| P36 \| PAP-IV	annexin A2	-	HPRD,BioGRID	7510700
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	-	HPRD	12485888
ARHGAP17	DKFZp564A1363 \| FLJ37567 \| FLJ43368 \| MGC87805 \| MST066 \| MST110 \| MSTP038 \| MSTP066 \| MSTP110 \| NADRIN \| RICH1 \| WBP15	Rho GTPase activating protein 17	Reconstituted Complex	BioGRID	11431473
AXL	JTK11 \| UFO	AXL receptor tyrosine kinase	Axl interacts with an unspecified isoform of Grb2.	BIND	12470648
AXL	JTK11 \| UFO	AXL receptor tyrosine kinase	-	HPRD,BioGRID	9178760
BAT2	D6S51 \| D6S51E \| DKFZp686D09175 \| G2	HLA-B associated transcript 2	-	HPRD,BioGRID	14667819
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD	8649368 \|8700507
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10085298 \|10822386
BCL2A1	ACC-1 \| ACC-2 \| BCL2L5 \| BFL1 \| GRS \| HBPA1	BCL2-related protein A1	-	HPRD	9670936
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	Grb2 interacts with Bcr-Abl.	BIND	9872323
			-	HPRD,BioGRID	8112292 \|9178913
			Tyrosine phosphorylated Bcr-Abl interacts with Grb2.	BIND	8112292
BLNK	BASH \| BLNK-S \| LY57 \| MGC111051 \| SLP-65 \| SLP65	B-cell linker	-	HPRD,BioGRID	9697839 \|9705962
CALD1	CDM \| H-CAD \| L-CAD \| MGC21352 \| NAG22	caldesmon 1	-	HPRD	10559276
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Grb2 interacts with Cbl.	BIND	15782196
			c-Cbl interacts with Grb2. This interaction was modeled on a demonstrated interaction between human c-Cbl and Grb2 from an unspecified species.	BIND	11053437
			Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8083187 \|9108392 \|9174058 \|9178909 \|9367879 \|9461587 \|9872323 \|10086340 \|10204582 \|10570290 \|11964172 \|11997436
			-	HPRD	9108392 \|9178909 \|11133830 \|11964172
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	-	HPRD,BioGRID	10086340
CCL5	D17S136E \| MGC17164 \| RANTES \| SCYA5 \| SISd \| TCP228	chemokine (C-C motif) ligand 5	-	HPRD	9009162
CD22	FLJ22814 \| MGC130020 \| SIGLEC-2 \| SIGLEC2	CD22 molecule	-	HPRD,BioGRID	11551923
CD28	MGC138290 \| Tp44	CD28 molecule	-	HPRD,BioGRID	7737275 \|8576157 \|9694876
CD2AP	CMS \| DKFZp586H0519	CD2-associated protein	-	HPRD	10339567
CD72	CD72b \| LYB2	CD72 molecule	-	HPRD	10820378
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	-	HPRD,BioGRID	11278754
CHRM4	HM4	cholinergic receptor, muscarinic 4	M4 interacts with Grb2.	BIND	9843378
CLYBL	CLB \| bA134O15.1	citrate lyase beta like	Affinity Capture-MS	BioGRID	12577067
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	8662907 \|8810325 \|10970810
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD	8662907 \|10970810
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	-	HPRD,BioGRID	10477741
CSF1R	C-FMS \| CD115 \| CSFR \| FIM2 \| FMS	colony stimulating factor 1 receptor	-	HPRD,BioGRID	8262059 \|9178909 \|9380408
CSF3R	CD114 \| GCSFR	colony stimulating factor 3 receptor (granulocyte)	-	HPRD,BioGRID	9824671
CTTN	EMS1 \| FLJ34459	cortactin	-	HPRD	11439336
DAG1	156DAG \| A3a \| AGRNR \| DAG	dystroglycan 1 (dystrophin-associated glycoprotein 1)	-	HPRD,BioGRID	7744812
DCTN1	DAP-150 \| DP-150 \| HMN7B \| P135	dynactin 1 (p150, glued homolog, Drosophila)	-	HPRD,BioGRID	8955163
DNM1	DNM	dynamin 1	Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	8119878 \|9009162
DNM1	DNM	dynamin 1	-	HPRD	8119878 \|11877424
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	Co-fractionation Reconstituted Complex	BioGRID	8657152 \|12615911
DRD3	D3DR \| ETM1 \| FET1 \| MGC149204 \| MGC149205	dopamine receptor D3	D3 interacts with Grb2.	BIND	9843378
DRD3	D3DR \| ETM1 \| FET1 \| MGC149204 \| MGC149205	dopamine receptor D3	-	HPRD,BioGRID	11384839
DRD4	D4DR	dopamine receptor D4	D4.7 interacts with Grb2.	BIND	9843378
			D4.4 interacts with Grb2.	BIND	9843378
			-	HPRD,BioGRID	9843378
			D4.2 interacts with Grb2.	BIND	9843378
DTX1	hDx-1	deltex homolog 1 (Drosophila)	-	HPRD,BioGRID	9590294
EGF	HOMG4 \| URG	epidermal growth factor (beta-urogastrone)	-	HPRD	10973965
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	GRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR.	BIND	15782189
			-	HPRD	1322798 \|7527043
			EGFR interacts with GRB2.	BIND	8305738
			Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	1322798 \|7510700 \|7527043 \|8647858 \|9050991 \|10026169 \|10085134 \|11960376 \|12577067 \|16729043
ELK1	-	ELK1, member of ETS oncogene family	-	HPRD	8798570
EPHA2	ECK	EPH receptor A2	-	HPRD,BioGRID	12400011
EPHB1	ELK \| EPHT2 \| FLJ37986 \| Hek6 \| NET	EPH receptor B1	-	HPRD,BioGRID	8798570
EPOR	MGC138358	erythropoietin receptor	-	HPRD,BioGRID	7534299
EPPK1	EPIPL \| EPIPL1	epiplakin 1	Affinity Capture-MS	BioGRID	12577067
EPS15	AF-1P \| AF1P \| MLLT5	epidermal growth factor receptor pathway substrate 15	Far Western	BioGRID	7797522
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD	11173924 \|11606575\|11606575
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1		-	HPRD,BioGRID	11606575
ERBB3	ErbB-3 \| HER3 \| LCCS2 \| MDA-BF-1 \| MGC88033 \| c-erbB-3 \| c-erbB3 \| erbB3-S \| p180-ErbB3 \| p45-sErbB3 \| p85-sErbB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	Affinity Capture-MS	BioGRID	16729043
ERBB4	HER4 \| MGC138404 \| p180erbB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	Affinity Capture-MS	BioGRID	16729043
ETV6	TEL \| TEL/ABL	ets variant 6	Affinity Capture-Western Far Western	BioGRID	15143164
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	-	HPRD,BioGRID	11741599 \|12023017
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	CD95L interacts with Grb2.	BIND	12023017
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	-	HPRD	9480847
FGFR3	ACH \| CD333 \| CEK2 \| HSFGFR3EX \| JTK4	fibroblast growth factor receptor 3	-	HPRD,BioGRID	9045692
FLT3	CD135 \| FLK2 \| STK1	fms-related tyrosine kinase 3	-	HPRD,BioGRID	10080542
FLT4	FLT41 \| LMPH1A \| PCL \| VEGFR3	fms-related tyrosine kinase 4	-	HPRD,BioGRID	7675451 \|7970715 \|8662748 \|9927207
FRS2	FRS2A \| FRS2alpha \| SNT \| SNT-1 \| SNT1	fibroblast growth factor receptor substrate 2	Affinity Capture-Western Reconstituted Complex	BioGRID	8780727 \|9182757 \|10092678 \|11997436
FRS2	FRS2A \| FRS2alpha \| SNT \| SNT-1 \| SNT1	fibroblast growth factor receptor substrate 2	-	HPRD	8780727\|9182757\|11997436 \|12402043
FRS3	FRS2B \| FRS2beta \| MGC17167 \| SNT-2 \| SNT2	fibroblast growth factor receptor substrate 3	-	HPRD	11432792
GAB1	-	GRB2-associated binding protein 1	-	HPRD,BioGRID	11314042 \|11960376
GAB2	KIAA0571	GRB2-associated binding protein 2	Affinity Capture-Western Reconstituted Complex	BioGRID	10391903 \|11782427 \|15143164
GAB2	KIAA0571	GRB2-associated binding protein 2	-	HPRD	10068651 \|11882361
GAB3	-	GRB2-associated binding protein 3	-	HPRD,BioGRID	11739737
GHR	GHBP	growth hormone receptor	-	HPRD,BioGRID	9632636
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	7716522
GRB7	-	growth factor receptor-bound protein 7	-	HPRD	10377264
GRLF1	GRF-1 \| KIAA1722 \| MGC10745 \| P190-A \| P190A \| p190RhoGAP	glucocorticoid receptor DNA binding factor 1	Affinity Capture-Western	BioGRID	12441060
HCLS1	CTTNL \| HS1	hematopoietic cell-specific Lyn substrate 1	Reconstituted Complex	BioGRID	9670936
HNRNPC	C1 \| C2 \| HNRNP \| HNRPC \| MGC104306 \| MGC105117 \| MGC117353 \| MGC131677 \| SNRPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	-	HPRD,BioGRID	9516488
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD	11352655
HTT	HD \| IT15	huntingtin	-	HPRD,BioGRID	9079622
HTT	HD \| IT15	huntingtin	HDP interacts with Grb2.	BIND	9079622
IL2RB	CD122 \| P70-75	interleukin 2 receptor, beta	-	HPRD,BioGRID	10602027
IL6ST	CD130 \| CDw130 \| GP130 \| GP130-RAPS \| IL6R-beta	interleukin 6 signal transducer (gp130, oncostatin M receptor)	Affinity Capture-Western Reconstituted Complex	BioGRID	9013873
INPP5D	MGC104855 \| MGC142140 \| MGC142142 \| SHIP \| SHIP1 \| SIP-145 \| hp51CN	inositol polyphosphate-5-phosphatase, 145kDa	-	HPRD,BioGRID	8723348
INSR	CD220 \| HHF5	insulin receptor	Affinity Capture-Western	BioGRID	9083103
IQGAP1	HUMORFA01 \| KIAA0051 \| SAR1 \| p195	IQ motif containing GTPase activating protein 1	Affinity Capture-MS	BioGRID	12577067
IRS1	HIRS-1	insulin receptor substrate 1	-	HPRD	7488107
IRS1	HIRS-1	insulin receptor substrate 1	Affinity Capture-Western Reconstituted Complex	BioGRID	8491186 \|8536716 \|12173038
IRS2	-	insulin receptor substrate 2	-	HPRD	9852124
IRS4	IRS-4 \| PY160	insulin receptor substrate 4	-	HPRD,BioGRID	9553137
ITGA2B	CD41 \| CD41B \| GP2B \| GPIIb \| GTA \| HPA3	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	-	HPRD,BioGRID	8631894 \|11964172
ITGA6	CD49f \| DKFZp686J01244 \| FLJ18737 \| ITGA6B \| VLA-6	integrin, alpha 6	-	HPRD	7556090
ITGB4	CD104	integrin, beta 4	-	HPRD	9171350
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	-	HPRD,BioGRID	10636929
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	8536716 \|11527382
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	7500025
JUB	Ajuba \| MGC15563	jub, ajuba homolog (Xenopus laevis)	-	HPRD	10330178
KDR	CD309 \| FLK1 \| VEGFR \| VEGFR2	kinase insert domain receptor (a type III receptor tyrosine kinase)	-	HPRD,BioGRID	10319320
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD	7799925 \|8576157 \|12112020
			Affinity Capture-Western Reconstituted Complex	BioGRID	9872323 \|10467411 \|11960376
			Grb2 interacts with Sam68.	BIND	9872323
KHDRBS2	FLJ38664 \| MGC26664 \| SLM-1 \| SLM1 \| bA535F17.1	KH domain containing, RNA binding, signal transduction associated 2	-	HPRD	10077576
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Kit interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse proteins.	BIND	10022833
			Grb2 interacts with c-Kit upon stimulation with SLF. This interaction was modeled on a demonstrated interaction between mouse Grb2 and human c-Kit.	BIND	7523381
			-	HPRD,BioGRID	10377264
KRT17	K17 \| PC \| PC2 \| PCHC1	keratin 17	Affinity Capture-MS	BioGRID	12577067
KRT18	CYK18 \| K18	keratin 18	Affinity Capture-MS	BioGRID	12577067
KRT7	CK7 \| K2C7 \| K7 \| MGC129731 \| MGC3625 \| SCL	keratin 7	Affinity Capture-MS	BioGRID	12577067
KRT8	CARD2 \| CK8 \| CYK8 \| K2C8 \| K8 \| KO	keratin 8	Affinity Capture-MS	BioGRID	12577067
LAT	LAT1 \| pp36	linker for activation of T cells	-	HPRD	9489702 \|12359715
LAT	LAT1 \| pp36	linker for activation of T cells	Affinity Capture-Western Reconstituted Complex	BioGRID	9489702 \|11368773 \|12186560
LAT2	HSPC046 \| LAB \| NTAL \| WBSCR15 \| WBSCR5 \| WSCR5	linker for activation of T cells family, member 2	-	HPRD,BioGRID	12514734
LAX1	FLJ20340 \| LAX	lymphocyte transmembrane adaptor 1	-	HPRD,BioGRID	12359715
LCP2	SLP-76 \| SLP76	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	Affinity Capture-Western Reconstituted Complex	BioGRID	8695800 \|8995445 \|10204582 \|10224278 \|11314042
LY6G6F	C6orf21 \| G6f \| LY6G6D \| NG32	lymphocyte antigen 6 complex, locus G6F	-	HPRD,BioGRID	12852788
MAP2	DKFZp686I2148 \| MAP2A \| MAP2B \| MAP2C	microtubule-associated protein 2	-	HPRD,BioGRID	10781592 \|11546790\|11546790
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9733714
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	-	HPRD,BioGRID	9346925 \|9788432 \|9891069
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	HPK1, a Ste-20 homologous serine/threonine kinase interacts with Grb2, an adaptor protein.	BIND	9891069
MAPK12	ERK3 \| ERK6 \| P38GAMMA \| PRKM12 \| SAPK-3 \| SAPK3	mitogen-activated protein kinase 12	-	HPRD	9019171
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	-	HPRD	8695800
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	Reconstituted Complex	BioGRID	7642542 \|9019171
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	-	HPRD,BioGRID	15467741
MERTK	MER \| MGC133349 \| RP38 \| c-mer	c-mer proto-oncogene tyrosine kinase	-	HPRD	9891051
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	-	HPRD,BioGRID	7511210 \|8662889 \|9660480
MICAL1	DKFZp434B1517 \| FLJ11937 \| FLJ21739 \| MICAL \| MICAL-1 \| NICAL	microtubule associated monoxygenase, calponin and LIM domain containing 1	Reconstituted Complex	BioGRID	11827972
MST1R	CD136 \| CDw136 \| PTK8 \| RON	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	-	HPRD,BioGRID	8918464
MTA1	-	metastasis associated 1	-	HPRD	11483358
MTA3	KIAA1266	metastasis associated 1 family, member 3	-	HPRD	11483358
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	-	HPRD,BioGRID	7664271
NCKIPSD	AF3P21 \| DIP \| DIP1 \| MGC23891 \| ORF1 \| SPIN90 \| WASLBP \| WISH	NCK interacting protein with SH3 domain	-	HPRD	11157975 \|11509578
NCKIPSD		NCK interacting protein with SH3 domain	-	HPRD,BioGRID	11157975
NEU3	FLJ12388 \| SIAL3	sialidase 3 (membrane sialidase)	-	HPRD,BioGRID	12730204
NTRK1	DKFZp781I14186 \| MTC \| TRK \| TRK1 \| TRKA \| p140-TrkA	neurotrophic tyrosine kinase, receptor, type 1	-	HPRD,BioGRID	10748052 \|11733534
OCRL	INPP5F \| LOCR \| NPHL2 \| OCRL1	oculocerebrorenal syndrome of Lowe	-	HPRD,BioGRID	9038219
PAG1	CBP \| FLJ37858 \| MGC138364 \| PAG	phosphoprotein associated with glycosphingolipid microdomains 1	-	HPRD,BioGRID	10790433
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	PAK1 interacts with Grb2.	BIND	12522133
PDE4D	DPDE3 \| HSPDE4D \| PDE4DN2 \| STRK1	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	PDE4D4 interacts with Grb2. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Grb2 from an unspecified species.	BIND	10571082
PDE6G	DKFZp686C0587 \| MGC125749 \| PDEG	phosphodiesterase 6G, cGMP-specific, rod, gamma	-	HPRD,BioGRID	12624098
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	Affinity Capture-Western	BioGRID	8943348
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	7935391
PIK3C2B	C2-PI3K \| DKFZp686G16234	phosphoinositide-3-kinase, class 2, beta polypeptide	-	HPRD,BioGRID	11533253
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	p85 interacts with Grb2.	BIND	8662998
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	7642542 \|7737969 \|7759531
PIK3R2	P85B \| p85 \| p85-BETA	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	-	HPRD	8662998
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD,BioGRID	9281317
PLEC1	EBS1 \| EBSO \| HD1 \| PCN \| PLEC1b \| PLTN	plectin 1, intermediate filament binding protein 500kDa	Affinity Capture-MS	BioGRID	12577067
PRKAR1A	CAR \| CNC \| CNC1 \| DKFZp779L0468 \| MGC17251 \| PKR1 \| PPNAD1 \| PRKAR1 \| TSE1	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	-	HPRD,BioGRID	9050991
PRNP	ASCR \| CD230 \| CJD \| GSS \| MGC26679 \| PRIP \| PrP \| PrP27-30 \| PrP33-35C \| PrPc \| prion	prion protein	-	HPRD	11571277
PSMD10	dJ889N15.2 \| p28	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	-	HPRD	9009162
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Tyrosine-phosphorylated FAK interacts with Grb2.	BIND	7597091
			-	HPRD	7997267
			Affinity Capture-Western Reconstituted Complex	BioGRID	8649427 \|10085298 \|10806474 \|12005431 \|12558988
			Grb2 interacts with FAK. This interaction was modeled on a demonstrated interaction between human Grb2 and mouse FAK.	BIND	9148935
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	10329689 \|10354709
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	-	HPRD	10660596 \|12388170
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	Reconstituted Complex	BioGRID	8940134 \|10660596
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	8041791 \|8702859 \|8995399 \|9362449 \|9632781 \|9824671 \|10080542 \|10212213 \|10747947
			-	HPRD	8041791 \|8702859 \|12531430
			Grb2 interacts with Syp via Syp SH2 domains.	BIND	7523381 \|8195176
PTPN12	PTP-PEST \| PTPG1	protein tyrosine phosphatase, non-receptor type 12	-	HPRD,BioGRID	9135065
PTPN22	LYP \| Lyp1 \| Lyp2 \| PEP \| PTPN8	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	-	HPRD,BioGRID	11882361
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	protein tyrosine phosphatase, non-receptor type 6	-	HPRD,BioGRID	11964172
PTPRA	HEPTP \| HLPR \| HPTPA \| HPTPalpha \| LRP \| PTPA \| PTPRL2 \| R-PTP-alpha \| RPTPA	protein tyrosine phosphatase, receptor type, A	An unspecified isoform of GRB2 interacts with PTPRA.	BIND	8670803
PTPRA		protein tyrosine phosphatase, receptor type, A	-	HPRD,BioGRID	7518772 \|8670803 \|11923305
PTPRC	B220 \| CD45 \| CD45R \| GP180 \| LCA \| LY5 \| T200	protein tyrosine phosphatase, receptor type, C	-	HPRD	8570203
PTPRE	DKFZp313F1310 \| FLJ57799 \| FLJ58245 \| HPTPE \| PTPE \| R-PTP-EPSILON	protein tyrosine phosphatase, receptor type, E	-	HPRD,BioGRID	10490839
PXN	FLJ16691	paxillin	Reconstituted Complex	BioGRID	10085298
RACGAP1	HsCYK-4 \| ID-GAP \| MgcRacGAP	Rac GTPase activating protein 1	Affinity Capture-MS	BioGRID	12577067
RALGPS1	KIAA0351 \| RALGEF2 \| RALGPS1A	Ral GEF with PH domain and SH3 binding motif 1	-	HPRD,BioGRID	10747847
RAPGEF1	C3G \| DKFZp781P1719 \| GRF2	Rap guanine nucleotide exchange factor (GEF) 1	-	HPRD,BioGRID	8621483
RAPSN	CMS1D \| CMS1E \| MGC3597 \| RNF205	receptor-associated protein of the synapse	-	HPRD	9856458
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	12441060
REPS2	POB1	RALBP1 associated Eps domain containing 2	-	HPRD,BioGRID	9422736
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	-	HPRD	9393871
RET		ret proto-oncogene	Reconstituted Complex	BioGRID	7665556 \|8183561
RHOU	ARHU \| CDC42L1 \| DJ646B12.2 \| FLJ10616 \| WRCH1 \| fJ646B12.2 \| hG28K	ras homolog gene family, member U	Wrch-1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between human Wrch-1 and Grb2 from an unspecified species.	BIND	15556869
SELL	CD62L \| LAM-1 \| LAM1 \| LECAM1 \| LNHR \| LSEL \| LYAM1 \| Leu-8 \| Lyam-1 \| PLNHR \| TQ1 \| hLHRc	selectin L	-	HPRD,BioGRID	8986819
SGCA	50-DAG \| A2 \| ADL \| DAG2 \| DMDA2 \| LGMD2D \| SCARMD1 \| adhalin	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	-	HPRD	7744812
SH2B1	DKFZp547G1110 \| FLJ30542 \| KIAA1299 \| SH2-B \| SH2B	SH2B adaptor protein 1	-	HPRD,BioGRID	9856458
SH2B2	APS	SH2B adaptor protein 2	Affinity Capture-Western	BioGRID	9856458
SH2B3	CELIAC13 \| LNK	SH2B adaptor protein 3	-	HPRD,BioGRID	8649391
SH3BP2	3BP2 \| CRBM \| CRPM \| FLJ42079 \| RES4-23	SH3-domain binding protein 2	-	HPRD,BioGRID	9846481
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	-	HPRD	9507006\|11152963
			SETA interacts with Grb2. This interaction was modelled on a demonstrated interaction between rat SETA and human Grb2	BIND	11152963
			Reconstituted Complex	BioGRID	10921882 \|11152963
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	-	HPRD,BioGRID	9484780 \|10488157
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Affinity Capture-MS Affinity Capture-Western Co-fractionation Reconstituted Complex	BioGRID	7514169 \|7524086 \|7535773 \|8112292 \|8195171 \|8294403 \|8491186 \|8647288 \|8662733 \|9045692 \|9083103 \|9927207 \|10080542 \|10477741 \|10570290 \|11302736 \|11505033 \|11964172 \|12441060 \|12577067
			Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species.	BIND	8084588
			-	HPRD	7524086 \|7535773 \|8491186 \|11707405
			An unspecified isoform of Grb2 interacts with the p52 isoform of Shc.	BIND	9148935
			Grb2 interacts with Shc.	BIND	7515480 \|8112292 \|8939605 \|10891441
SHC3	N-Shc \| NSHC \| RAI \| SHCC	SHC (Src homology 2 domain containing) transforming protein 3	An unspecified isoform of GRB2 interacts with SHC3 (ShcC).	BIND	15735675
SHKBP1	PP203 \| Sb1	SH3KBP1 binding protein 1	-	HPRD,BioGRID	11152963
SIGLEC7	AIRM1 \| CD328 \| CDw328 \| D-siglec \| QA79 \| SIGLEC-7 \| p75 \| p75/AIRM1	sialic acid binding Ig-like lectin 7	-	HPRD	8188688
SIT1	MGC125908 \| MGC125909 \| MGC125910 \| RP11-331F9.5 \| SIT	signaling threshold regulating transmembrane adaptor 1	-	HPRD	11433379
SKAP1	SCAP1 \| SKAP55	src kinase associated phosphoprotein 1	-	HPRD,BioGRID	12171928
SNTA1	SNT1 \| TACIP1 \| dJ1187J4.5	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	-	HPRD,BioGRID	11278583 \|11551227
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	Socs1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse Socs1 and human Grb2.	BIND	10022833
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	-	HPRD,BioGRID	10022833
SOCS7	NAP4	suppressor of cytokine signaling 7	-	HPRD	9344857
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	Grb2 interacts with Sos1. This interaction was modelled on a demonstrated interaction between rat Grb2 and Sos1.	BIND	8112292
			-	HPRD	8479541 \|8493579
			Affinity Capture-MS Affinity Capture-Western Far Western Reconstituted Complex Two-hybrid	BioGRID	7510700 \|7514169 \|7629168 \|7664271 \|8112292 \|8188688 \|8479541 \|8695800 \|8810325 \|9009162 \|9344843 \|9872323 \|10207103 \|10319320 \|10477741 \|10570290 \|10716926 \|11960376 \|11964172 \|11997436 \|12577067
			GRB2 interacts with SOS. This interaction was modeled on a demonstrated interaction between human GRB2 and mouse SOS.	BIND	7862111
			Sos1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between Sos1 and Grb2 from Bos taurus.	BIND	9374537
SOS2	FLJ25596	son of sevenless homolog 2 (Drosophila)	-	HPRD,BioGRID	7629138 \|10940929
SPRY1	hSPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	-	HPRD	12402043
SPRY2	MGC23039 \| hSPRY2	sprouty homolog 2 (Drosophila)	-	HPRD,BioGRID	10940627 \|12402043
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	11964172
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD,BioGRID	11964172
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD	8022809
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD,BioGRID	8022809\|10899172
SYNCRIP	GRY-RBP \| HNRPQ1 \| NSAP1 \| RP1-3J17.2 \| dJ3J17.2 \| hnRNP-Q \| pp68	synaptotagmin binding, cytoplasmic RNA interacting protein	Reconstituted Complex	BioGRID	9341187
SYNJ2	INPP5H \| KIAA0348 \| MGC44422	synaptojanin 2	-	HPRD	9388224
SYP	-	synaptophysin	Affinity Capture-Western	BioGRID	7534299
TEK	CD202B \| TIE-2 \| TIE2 \| VMCM \| VMCM1	TEK tyrosine kinase, endothelial	-	HPRD	7478529 \|10521483
TFAP2A	AP-2 \| AP-2alpha \| AP2TF \| BOFS \| TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Affinity Capture-MS	BioGRID	12577067
TFAP2B	AP-2B \| AP2-B \| MGC21381	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	Affinity Capture-MS	BioGRID	12577067
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	-	HPRD,BioGRID	10359574
TNK2	ACK \| ACK1 \| FLJ44758 \| FLJ45547 \| p21cdc42Hs	tyrosine kinase, non-receptor, 2	-	HPRD,BioGRID	8647288
TOM1L1	OK/KNS-CL.3 \| SRCASM	target of myb1 (chicken)-like 1	-	HPRD,BioGRID	11711534
TP63	AIS \| B(p51A) \| B(p51B) \| EEC3 \| KET \| LMS \| NBP \| OFC8 \| RHS \| SHFM4 \| TP53CP \| TP53L \| TP73L \| p40 \| p51 \| p53CP \| p63 \| p73H \| p73L	tumor protein p63	-	HPRD	8695800
TRAT1	HSPC062 \| TCRIM \| TRIM	T cell receptor associated transmembrane adaptor 1	Reconstituted Complex	BioGRID	10790433
TUB	rd5	tubby homolog (mouse)	-	HPRD	10455176
USP6NL	KIAA0019 \| RNTRE \| TRE2NL	USP6 N-terminal like	Grb2 interacts with RN-tre.	BIND	12399475
USP6NL	KIAA0019 \| RNTRE \| TRE2NL	USP6 N-terminal like	-	HPRD,BioGRID	12399475
USP8	FLJ34456 \| HumORF8 \| KIAA0055 \| MGC129718 \| UBPY	ubiquitin specific peptidase 8	-	HPRD,BioGRID	10982817 \|13129930
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	7809090
VAV1	VAV	vav 1 guanine nucleotide exchange factor	Grb2 interacts with Vav	BIND	9013873
VAV2	-	vav 2 guanine nucleotide exchange factor	-	HPRD,BioGRID	11606575
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD,BioGRID	11094073
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	Affinity Capture-Western Reconstituted Complex	BioGRID	8805332 \|9307968
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD	9307968 \|10224664
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	-	HPRD	9307968
WASF2	SCAR2 \| WAVE2 \| dJ393P12.2	WAS protein family, member 2	-	HPRD	9307968
WASL	DKFZp779G0847 \| MGC48327 \| N-WASP \| NWASP	Wiskott-Aldrich syndrome-like	-	HPRD,BioGRID	10087612 \|10781580
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	Affinity Capture-Western	BioGRID	7629168

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY	87	71	All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY	190	128	All SZGR genes in this pathway
KEGG_DORSO_VENTRAL_AXIS_FORMATION	25	21	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_GAP_JUNCTION	90	68	All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY	155	105	All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	137	92	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	75	56	All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	79	58	All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	126	103	All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY	137	103	All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY	101	77	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA	70	60	All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER	52	45	All SZGR genes in this pathway
KEGG_GLIOMA	65	56	All SZGR genes in this pathway
KEGG_PROSTATE_CANCER	89	75	All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA	73	59	All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA	60	47	All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER	54	47	All SZGR genes in this pathway
BIOCARTA_SRCRPTP_PATHWAY	11	9	All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY	36	28	All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY	37	28	All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY	45	35	All SZGR genes in this pathway
BIOCARTA_CBL_PATHWAY	13	10	All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY	31	25	All SZGR genes in this pathway
BIOCARTA_EPO_PATHWAY	19	13	All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY	28	22	All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY	41	30	All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY	28	22	All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY	21	16	All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_IL3_PATHWAY	15	11	All SZGR genes in this pathway
BIOCARTA_IL4_PATHWAY	11	8	All SZGR genes in this pathway
BIOCARTA_IL6_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY	38	26	All SZGR genes in this pathway
BIOCARTA_GLEEVEC_PATHWAY	23	17	All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY	38	29	All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY	31	24	All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY	87	68	All SZGR genes in this pathway
BIOCARTA_IGF1R_PATHWAY	23	20	All SZGR genes in this pathway
BIOCARTA_NGF_PATHWAY	18	13	All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY	40	31	All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY	32	25	All SZGR genes in this pathway
BIOCARTA_PTEN_PATHWAY	18	14	All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY	22	17	All SZGR genes in this pathway
BIOCARTA_ERK5_PATHWAY	18	15	All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY	37	30	All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY	18	15	All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY	49	37	All SZGR genes in this pathway
BIOCARTA_CTLA4_PATHWAY	21	18	All SZGR genes in this pathway
BIOCARTA_TPO_PATHWAY	24	17	All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY	27	25	All SZGR genes in this pathway
BIOCARTA_TFF_PATHWAY	21	15	All SZGR genes in this pathway
BIOCARTA_TRKA_PATHWAY	12	10	All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES	24	20	All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY	32	25	All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	67	54	All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY	35	29	All SZGR genes in this pathway
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	27	23	All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY	82	62	All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	51	41	All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION	45	33	All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY	46	38	All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR	40	32	All SZGR genes in this pathway
ST_INTERLEUKIN_4_PATHWAY	26	18	All SZGR genes in this pathway
SA_PTEN_PATHWAY	17	14	All SZGR genes in this pathway
SA_TRKA_RECEPTOR	17	15	All SZGR genes in this pathway
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	37	29	All SZGR genes in this pathway
PID_FCER1_PATHWAY	62	43	All SZGR genes in this pathway
PID_BCR_5PATHWAY	65	50	All SZGR genes in this pathway
PID_ERBB4_PATHWAY	38	32	All SZGR genes in this pathway
PID_INSULIN_PATHWAY	45	32	All SZGR genes in this pathway
PID_GMCSF_PATHWAY	37	31	All SZGR genes in this pathway
PID_IL4_2PATHWAY	65	43	All SZGR genes in this pathway
PID_TCR_PATHWAY	66	51	All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY	41	35	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_PTP1B_PATHWAY	52	40	All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY	40	38	All SZGR genes in this pathway
PID_RET_PATHWAY	39	29	All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY	53	42	All SZGR genes in this pathway
PID_TCPTP_PATHWAY	43	33	All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	50	41	All SZGR genes in this pathway
PID_SHP2_PATHWAY	58	46	All SZGR genes in this pathway
PID_IL2_1PATHWAY	55	43	All SZGR genes in this pathway
PID_IGF1_PATHWAY	30	23	All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	35	29	All SZGR genes in this pathway
PID_IL5_PATHWAY	14	11	All SZGR genes in this pathway
PID_IL2_PI3K_PATHWAY	34	27	All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY	105	78	All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY	44	35	All SZGR genes in this pathway
PID_IL3_PATHWAY	27	19	All SZGR genes in this pathway
PID_IL6_7_PATHWAY	47	40	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY	31	24	All SZGR genes in this pathway
PID_PDGFRA_PATHWAY	22	18	All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY	41	35	All SZGR genes in this pathway
PID_KIT_PATHWAY	52	40	All SZGR genes in this pathway
PID_EPO_PATHWAY	34	29	All SZGR genes in this pathway
PID_IL2_STAT5_PATHWAY	30	23	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY	46	35	All SZGR genes in this pathway
PID_RAS_PATHWAY	30	22	All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY	36	31	All SZGR genes in this pathway
PID_EPHA2_FWD_PATHWAY	19	16	All SZGR genes in this pathway
PID_LYMPH_ANGIOGENESIS_PATHWAY	25	16	All SZGR genes in this pathway
PID_FGF_PATHWAY	55	37	All SZGR genes in this pathway
PID_FAK_PATHWAY	59	45	All SZGR genes in this pathway
PID_TGFBR_PATHWAY	55	38	All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF	217	167	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT	78	59	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	14	9	All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION	120	77	All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING	37	24	All SZGR genes in this pathway
REACTOME_REGULATION_OF_KIT_SIGNALING	17	10	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4	90	67	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2	101	78	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR	18	13	All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING	22	20	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING	20	17	All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING	44	34	All SZGR genes in this pathway
REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	29	24	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	126	90	All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	87	64	All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS	27	23	All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL	91	65	All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE	137	105	All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS	36	30	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE	127	88	All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	205	136	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR1_MUTANTS	30	20	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS	19	12	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_MUTANTS	44	29	All SZGR genes in this pathway
REACTOME_EGFR_DOWNREGULATION	25	14	All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME	38	29	All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING	15	13	All SZGR genes in this pathway
REACTOME_TIE2_SIGNALING	17	13	All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	79	48	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_	15	10	All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING	27	17	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF	122	93	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	95	76	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	64	49	All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION	32	26	All SZGR genes in this pathway
REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	11	10	All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	63	48	All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE	36	27	All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE	56	39	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR	100	74	All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_CASCADE	28	19	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS	107	86	All SZGR genes in this pathway
REACTOME_REGULATION_OF_SIGNALING_BY_CBL	18	16	All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING	43	34	All SZGR genes in this pathway
REACTOME_IL_RECEPTOR_SHC_SIGNALING	27	21	All SZGR genes in this pathway
REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS	12	10	All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING	41	34	All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	36	23	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	108	72	All SZGR genes in this pathway
REACTOME_SIGNAL_ATTENUATION	14	8	All SZGR genes in this pathway
REACTOME_SOS_MEDIATED_SIGNALLING	14	13	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_SIGNALLING	15	12	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	208	138	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR	112	80	All SZGR genes in this pathway
REACTOME_PI3K_CASCADE	71	51	All SZGR genes in this pathway
REACTOME_SHC_RELATED_EVENTS	17	13	All SZGR genes in this pathway
CHANDRAN_METASTASIS_TOP50_UP	38	27	All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP	305	185	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP	380	236	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP	418	263	All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP	414	287	All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP	358	245	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN	98	59	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON	335	181	All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6	144	98	All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN	141	99	All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_DN	57	39	All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP	249	170	All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_DN	16	12	All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT	51	41	All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C4	18	12	All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2	163	113	All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP	113	71	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP	210	124	All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_UP	20	14	All SZGR genes in this pathway
QI_PLASMACYTOMA_UP	259	185	All SZGR genes in this pathway
ALONSO_METASTASIS_UP	198	128	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP	165	118	All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES	31	26	All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP	288	168	All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN	225	124	All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP	221	135	All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_METHOTREXATE	18	9	All SZGR genes in this pathway
SUBTIL_PROGESTIN_TARGETS	36	25	All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP	194	133	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP	271	165	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN	448	282	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	658	397	All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN	784	464	All SZGR genes in this pathway
ZHANG_ADIPOGENESIS_BY_BMP7	14	12	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	996	1002	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	996	1002	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	2260	2266	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	2260	2266	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-141/200a	2190	2196	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2190	2196	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-153	375	382	1A,m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-182	183	189	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-27	2260	2267	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	2260	2267	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-320	1232	1239	1A,m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-329	2165	2171	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-376c	2208	2214	1A	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-433-3p	2137	2144	1A,m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-448	376	382	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-96	183	189	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.