Gene Page: IGF2R

Summary
GeneID  3482
Symbol  IGF2R
Synonyms  CD222|CIMPR|M6P-R|MPR1|MPRI
Description  insulin-like growth factor 2 receptor
See related  HGNC:5467|MIM:147280|Ensembl:ENSG00000197081|HPRD:00928|
Locus tag  -
Gene type  protein-coding
Map location  6q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005010insulin-like growth factor receptor activityTAS10799489 
GO:0004872receptor activityTAS7753549 
GO:0005515protein bindingIEA-
GO:0005520insulin-like growth factor bindingIEA-
GO:0005215transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS7753549 
GO:0006810transportIEA-
GO:0006898receptor-mediated endocytosisTAS10799489 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005641nuclear envelope lumenIEA-
GO:0005737cytoplasmIEA-
GO:0005765lysosomal membraneIEA-
GO:0005768endosomeIDA15078902 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS10799489 
GO:0030140trans-Golgi network transport vesicleIDA15078902 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGAAGU | ASRG | GAaspartylglucosaminidase-HPRD9362483 
CREG1CREGcellular repressor of E1A-stimulated genes 1-HPRD,BioGRID12934103 
CTSDCLN10 | CPSD | MGC2311cathepsin DCTSD (CD) interacts with IGF2R (MPR300).BIND15258139 
GGA1-golgi associated, gamma adaptin ear containing, ARF binding protein 1-HPRD11387475 |11390366 
GGA2FLJ20966 | KIAA1080 | VEARgolgi associated, gamma adaptin ear containing, ARF binding protein 2-HPRD11387476 
-HPRD11387475 |11387476 
GGA3KIAA0154golgi associated, gamma adaptin ear containing, ARF binding protein 3-HPRD11387475 
GZMBCCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECTgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)-HPRD11081635 
M6PRBP1MGC11117 | MGC2012 | PP17 | TIP47mannose-6-phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).BIND9590177 
-HPRD,BioGRID9590177 |10908666 
M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).BIND10908666 
M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).BIND11359012 
M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).BIND12032303 
M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).BIND10829017 
TIP47 interacts with CI-MPR. This interaction was modeled on a demostrated interaction between a modified synthetic peptide representing human TIP47 and CI-MPR from an unspecified species.BIND15782153 
PACS1FLJ10209 | KIAA1175phosphofurin acidic cluster sorting protein 1-HPRD9695949 |11331585 
PLAUATF | UPA | URK | UROKINASE | u-PAplasminogen activator, urokinase-HPRD9566979 
PLAURCD87 | UPAR | URKRplasminogen activator, urokinase receptorReconstituted ComplexBioGRID9566979 
USF1FCHL | FCHL1 | HYPLIP1 | MLTF | MLTFI | UEF | bHLHb11upstream transcription factor 1An unspecified isoform of USF1 interacts with IGF2R promoter.BIND12857727 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interactingAn unspecified isoform of USF2 interacts with IGF2R promoter.BIND12857727 
WISP2CCN5 | CT58 | CTGF-LWNT1 inducible signaling pathway protein 2-HPRD10358067 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LYSOSOME 12183All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 6031All SZGR genes in this pathway
REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 5327All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_65_UP 2213All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP 176111All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_UP 11071All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_UP 7848All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_UP 7148All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C3 1410All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P7 9052All SZGR genes in this pathway
JEPSEN_SMRT_TARGETS 3323All SZGR genes in this pathway
COATES_MACROPHAGE_M1_VS_M2_DN 7844All SZGR genes in this pathway
POS_RESPONSE_TO_HISTAMINE_UP 1310All SZGR genes in this pathway
POS_HISTAMINE_RESPONSE_NETWORK 3222All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
KUROKAWA_LIVER_CANCER_EARLY_RECURRENCE_DN 76All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_DN 1713All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_DN 2724All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.199810041Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-15/16/195/424/497318324m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-185372378m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-19100510121A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-204/2111141211A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-224101710241A,m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p1771841A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-381127012761Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-542-5p6546601Ahsa-miR-542-5pUCGGGGAUCAUCAUGUCACGAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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