Gene Page: MYO6

Summary
GeneID  4646
Symbol  MYO6
Synonyms  DFNA22|DFNB37|KIAA0389
Description  myosin VI
See related  HGNC:7605|MIM:600970|Ensembl:ENSG00000196586|HPRD:02985|
Locus tag  RP3-472A9.1
Gene type  protein-coding
Map location  6q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003774motor activityIEA-
GO:0003774motor activityISS-
GO:0005516calmodulin bindingISS-
GO:0005516calmodulin bindingTAS12857860 
GO:0005524ATP bindingIEA-
GO:0051015actin filament bindingIDA9852149 
GO:0051015actin filament bindingISS-
GO:0042803protein homodimerization activityNAS11728438 
GO:0043531ADP bindingISS-
GO:0060001minus-end directed microfilament motor activityNAS10519557 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
GO:0007605sensory perception of soundIDA11468689 
GO:0007605sensory perception of soundIEA-
GO:0030048actin filament-based movementISS-
GO:0030048actin filament-based movementNAS10519557 
GO:0006897endocytosisIMP15247260 
GO:0006897endocytosisISS-
GO:0006886intracellular protein transportISS-
GO:0051046regulation of secretionIMP15837803 
GO:0030330DNA damage response, signal transduction by p53 class mediatorIDA16507995 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP16949370 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleIDA9852149 |16507995 
GO:0005794Golgi apparatusIDA16507995 
GO:0005634nucleusIDA16507995 
GO:0005654nucleoplasmIDA16948370 
GO:0005737cytoplasmIDA9852149 |16507995 |16949370 
GO:0005737cytoplasmISS-
GO:0005938cell cortexISS-
GO:0005905coated pitIEA-
GO:0005886plasma membraneIEA-
GO:0048471perinuclear region of cytoplasmIDA9852149 
GO:0048471perinuclear region of cytoplasmISS-
GO:0016461unconventional myosin complexNAS8022818 
GO:0016461unconventional myosin complexTAS9259267 
GO:0016591DNA-directed RNA polymerase II, holoenzymeIDA16949370 
GO:0031965nuclear membraneIDA16507995 
GO:0031941filamentous actinIDA9852149 
GO:0031941filamentous actinISS-
GO:0031941filamentous actinISS-
GO:0045334clathrin-coated endocytic vesicleIDA11447109 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALM2CAMII | PHKD | PHKD2calmodulin 2 (phosphorylase kinase, delta)Two-hybridBioGRID16169070 
DAB1-disabled homolog 1 (Drosophila)Reconstituted ComplexBioGRID11967127 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)-HPRD,BioGRID11906161 |11967127 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD12050163 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1-HPRD12857860 |12893809 
Affinity Capture-MS
Affinity Capture-Western		BioGRID12857860 |17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
REACTOME_GAP_JUNCTION_DEGRADATION 108All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_GAP_JUNCTION_TRAFFICKING 2719All SZGR genes in this pathway
LIU_PROSTATE_CANCER_UP 9657All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_DN 8453All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
HOOI_ST7_TARGETS_UP 9457All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP 13784All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN 230115All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
HEIDENBLAD_AMPLICON_8Q24_UP 4023All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_DN 9751All SZGR genes in this pathway
TOMLINS_PROSTATE_CANCER_UP 4027All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_UP 5734All SZGR genes in this pathway
LIN_SILENCED_BY_TUMOR_MICROENVIRONMENT 10873All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P2 7955All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_DN 10563All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_DN 5944All SZGR genes in this pathway
ROSS_LEUKEMIA_WITH_MLL_FUSIONS 7849All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_UP 6748All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
NIELSEN_GIST 9866All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
REICHERT_MITOSIS_LIN9_TARGETS 2817All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1438408471A,m8hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-145448444901Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-146284028461Ahsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-2314781484m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-299-5p226522711Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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