Gene Page: SERPINE2

Summary
GeneID  5270
Symbol  SERPINE2
Synonyms  GDN|PI7|PN1|PNI
Description  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
See related  HGNC:8951|MIM:177010|Ensembl:ENSG00000135919|HPRD:01510|
Locus tag  -
Gene type  protein-coding
Map location  2q33-q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004867serine-type endopeptidase inhibitor activityNAS2877744 |3997857 
GO:0008201heparin bindingNAS3997857 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0030162regulation of proteolysisNAS2877744 |3997857 
GO:0030334regulation of cell migrationNAS2877744 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS2877744 |3997857 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
COL4A1arrestencollagen, type IV, alpha 1-HPRD,BioGRID8006028 
COL4A2DKFZp686I14213 | FLJ22259collagen, type IV, alpha 2-HPRD,BioGRID8006028 
COL4A3-collagen, type IV, alpha 3 (Goodpasture antigen)-HPRD,BioGRID8006028 
COL4A4CA44collagen, type IV, alpha 4-HPRD,BioGRID8006028 
COL4A5ASLN | ATS | CA54 | MGC167109 | MGC42377collagen, type IV, alpha 5-HPRD,BioGRID8006028 
COL4A6MGC88184collagen, type IV, alpha 6-HPRD,BioGRID8006028 
PLAUATF | UPA | URK | UROKINASE | u-PAplasminogen activator, urokinaseReconstituted ComplexBioGRID9184208 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_DN 2113All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_DN 8659All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP 8745All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
CASTELLANO_NRAS_TARGETS_UP 6841All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_D_UP 3823All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP 5844All SZGR genes in this pathway
MAHADEVAN_IMATINIB_RESISTANCE_UP 2315All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP 176111All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_UP 4424All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
LIAO_HAVE_SOX4_BINDING_SITES 4026All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP 3532All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
SWEET_KRAS_TARGETS_UP 8451All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MS_UP 4832All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
ONGUSAHA_TP53_TARGETS 3823All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_UP 5635All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_UP 3123All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
BURTON_ADIPOGENESIS_7 5134All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION 1513All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_DN 6038All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
LE_SKI_TARGETS_UP 1712All SZGR genes in this pathway
WILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_UP 2114All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_UP 5429All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN 14279All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_UP 3521All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
LEE_SP4_THYMOCYTE 1411All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_HD_MTX_DN 2518All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP 166105All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_DN 3827All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_DN 3825All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP 12170All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
GUILLAUMOND_KLF10_TARGETS_UP 5139All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
BOUDOUKHA_BOUND_BY_IGF2BP2 11159All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-4105485541Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-542-3p628634m8hsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.