Gene Page: PTPN1

Summary
GeneID  5770
Symbol  PTPN1
Synonyms  PTP1B
Description  protein tyrosine phosphatase, non-receptor type 1
See related  HGNC:9642|MIM:176885|Ensembl:ENSG00000196396|HPRD:01477|
Locus tag  -
Gene type  protein-coding
Map location  20q13.1-q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0757 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF1420.940.95
ZNF3840.940.96
PFAS0.940.96
HCFC10.940.94
DNMT10.940.96
ZMIZ10.940.95
GCN1L10.940.95
KIAA12670.940.95
BRPF10.940.95
SAP1300.940.96
Top 10 negatively co-expressed genes
AF347015.31-0.74-0.89
AF347015.27-0.72-0.88
MT-CO2-0.72-0.89
AF347015.33-0.71-0.85
C5orf53-0.70-0.77
FXYD1-0.70-0.85
COPZ2-0.70-0.81
S100B-0.70-0.84
MT-CYB-0.70-0.85
AF347015.8-0.69-0.87
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11106648 |12907755 |16291744 
|17159996 
GO:0004725protein tyrosine phosphatase activityTAS10748206 
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006470protein amino acid dephosphorylationIEA-
GO:0007165signal transductionTAS10748206 
GO:0008286insulin receptor signaling pathwayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD11579209 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID8940134 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDacaveolin-1 interacts with PTP1B.BIND12176037 
-HPRD,BioGRID12176037 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)-HPRD12377785 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Reconstituted ComplexBioGRID8940134 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD,BioGRID12377785 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID7540771 |8621392 
|10889023 |12573287 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD10660596 |12388170 
Reconstituted ComplexBioGRID8940134 |10660596 
GSK3B-glycogen synthase kinase 3 beta-HPRD,BioGRID7514173 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID8999839 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID8826975 
IRS1HIRS-1insulin receptor substrate 1-HPRD,BioGRID10660596 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID11694501 
LTKTYK1leukocyte receptor tyrosine kinase-HPRD,BioGRID12237455 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1-HPRD,BioGRID12237455 
NTRK2GP145-TrkB | TRKBneurotrophic tyrosine kinase, receptor, type 2-HPRD,BioGRID12237455 
NTRK3TRKC | gp145(trkC)neurotrophic tyrosine kinase, receptor, type 3-HPRD,BioGRID12237455 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1-HPRD9499405 
RRAS2TC21related RAS viral (r-ras) oncogene homolog 2-HPRD,BioGRID11788587 
TYK2JTK1tyrosine kinase 2in vivoBioGRID11694501 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
PID_INSULIN_PATHWAY 4532All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_IGF1_PATHWAY 3023All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 2419All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 2717All SZGR genes in this pathway
REACTOME_REGULATION_OF_IFNG_SIGNALING 1410All SZGR genes in this pathway
REACTOME_INTERFERON_GAMMA_SIGNALING 6348All SZGR genes in this pathway
REACTOME_INTERFERON_ALPHA_BETA_SIGNALING 6450All SZGR genes in this pathway
REACTOME_REGULATION_OF_IFNA_SIGNALING 2422All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
CHIN_BREAST_CANCER_COPY_NUMBER_UP 2718All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
COLLIS_PRKDC_REGULATORS 1510All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON 14976All SZGR genes in this pathway
ZUCCHI_METASTASIS_UP 4324All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_1_UP 4629All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_UP 4430All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D7 4021All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C 6949All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206106910761A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124.1176417711A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506176417701Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-2214261432m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-299-5p181918251Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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