Gene Page: RASA1

Summary
GeneID  5921
Symbol  RASA1
Synonyms  CM-AVM|CMAVM|DKFZp434N071|GAP|PKWS|RASA|RASGAP|p120GAP|p120RASGAP
Description  RAS p21 protein activator (GTPase activating protein) 1
See related  HGNC:9871|MIM:139150|Ensembl:ENSG00000145715|HPRD:00745|
Locus tag  -
Gene type  protein-coding
Map location  5q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2213 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)2157284 |2176151 
GO:0005099Ras GTPase activator activityTAS2188736 
GO:0019870potassium channel inhibitor activityNAS1553544 
GO:0051020GTPase bindingIPI2122974 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0043524negative regulation of neuron apoptosisISSneuron (GO term level: 9)-
GO:0001570vasculogenesisISS-
GO:0000910cytokinesisISS-
GO:0001953negative regulation of cell-matrix adhesionIDA8344248 
GO:0007242intracellular signaling cascadeNAS1581965 
GO:0008360regulation of cell shapeNAS9113414 
GO:0009790embryonic developmentISS-
GO:0051056regulation of small GTPase mediated signal transductionIEA-
GO:0051252regulation of RNA metabolic processNAS9113414 
GO:0030833regulation of actin filament polymerizationIDA8344248 
GO:0045768positive regulation of anti-apoptosisIDA15542850 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleIEA-
GO:0005622intracellularIEA-
GO:0005737cytoplasmNAS2821624 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinasec-Abl interacts with GAP.BIND1383690 
ALKCD246 | Ki-1 | TFG/ALKanaplastic lymphoma receptor tyrosine kinase-HPRD9174053 
ANXA6ANX6 | CBP68annexin A6-HPRD,BioGRID8798684 |10571081 
Annexin VI interacts with GAP.BIND10571081 
ARHGAP1CDC42GAP | RHOGAP | RHOGAP1 | p50rhoGAPRho GTPase activating protein 1-HPRD9034330 
ARHGAP5GFI2 | RhoGAP5 | p190-BRho GTPase activating protein 5GAP interacts with p190. This interaction was modeled on a demonstrated interaction between human GAP and rat p190.BIND1689011 |8344248 
|10769036 
-HPRD8537347 
AURKAAIK | ARK1 | AURA | AURORA2 | BTAK | MGC34538 | STK15 | STK6 | STK7aurora kinase ARasGAP interacts with HsAIRK-1.BIND11976319 
AURKBAIK2 | AIM-1 | AIM1 | ARK2 | AurB | IPL1 | STK12 | STK5aurora kinase B-HPRD11976319 
RasGAP interacts with HsAIRK-2 in the RasGAP/HsAIRK-2/survivin complex.BIND11976319 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionBCR interacts with GAP. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human GAP.BIND1383690 
BIRC5API4 | EPR-1baculoviral IAP repeat-containing 5-HPRD11976319 
CAV2CAV | MGC12294caveolin 2Affinity Capture-Western
Reconstituted Complex		BioGRID12091389 
CD5LEU1 | T1CD5 molecule-HPRD,BioGRID9603468 
CSF1RC-FMS | CD115 | CSFR | FIM2 | FMScolony stimulating factor 1 receptor-HPRD,BioGRID2172781 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID7544435 
DNAJA3FLJ45758 | TID1 | hTid-1DnaJ (Hsp40) homolog, subfamily A, member 3-HPRD,BioGRID11116152 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD,BioGRID9008161 
DOK1 interacts with RASGAPBIND10822173 
DOK2p56DOK | p56dok-2docking protein 2, 56kDaAffinity Capture-WesternBioGRID10822173 
Dok2 interacts with RASGAPBIND10822173 
-HPRD10508618 |10799545 
DOK4FLJ10488docking protein 4-HPRD12730241 
IRS5/DOK4 interacts with RasGAP. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster RasGAP.BIND12730241 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Reconstituted ComplexBioGRID8647858 
GAP interacts with EGFR.BIND1385407 |1850098 
|2176151 
-HPRD1633149 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2-HPRD,BioGRID9233798 |10644995 
EPHB3ETK2 | HEK2 | TYRO6EPH receptor B3-HPRD,BioGRID9674711 
FESFPSfeline sarcoma oncogene-HPRD,BioGRID7691175 
G3BP1G3BP | HDH-VIII | MGC111040GTPase activating protein (SH3 domain) binding protein 1-HPRD,BioGRID9632780 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1RACK1 interacts with p120GAP.This interaction was modeled on a demonstrated interaction between RACK1 from mouse and rat, and human p120GAP.BIND11350068 
-HPRD,BioGRID11350068 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID12441060 
GRLF1GRF-1 | KIAA1722 | MGC10745 | P190-A | P190A | p190RhoGAPglucocorticoid receptor DNA binding factor 1Reconstituted ComplexBioGRID9034330 
HCKJTK9hemopoietic cell kinase-HPRD,BioGRID7782336 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD,BioGRID7628625 |9219684 
-HPRD2833817 |7628625 
|8663024 |9219684 
HSPD1CPN60 | GROEL | HSP60 | HSP65 | HuCHA60 | SPG13heat shock 60kDa protein 1 (chaperonin)-HPRD1347942 
HTTHD | IT15huntingtinHDP interacts with RasGAP.BIND9079622 
-HPRD,BioGRID9079622 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID7642582 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID1331107 
KDRCD309 | FLK1 | VEGFR | VEGFR2kinase insert domain receptor (a type III receptor tyrosine kinase)Affinity Capture-WesternBioGRID10319320 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1-HPRD,BioGRID11604231 
Sam68 interacts with the SH2 domains of p120GAP, preferentially with the C-terminal SH2 domain. This interaction was modelled based on a demonstrated interaction between rat proteins.BIND11604231 
MAGI1AIP3 | BAIAP1 | BAP1 | MAGI-1 | TNRC19 | WWP3membrane associated guanylate kinase, WW and PDZ domain containing 1-HPRD9169421 
MAP4K4FLH21957 | FLJ10410 | FLJ20373 | FLJ90111 | HGK | KIAA0687 | NIKmitogen-activated protein kinase kinase kinase kinase 4-HPRD,BioGRID10669731 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD10508618 
Affinity Capture-WesternBioGRID9233798 
PAG1CBP | FLJ37858 | MGC138364 | PAGphosphoprotein associated with glycosphingolipid microdomains 1-HPRD10790433 
PDE6DPDEDphosphodiesterase 6D, cGMP-specific, rod, delta-HPRD11786539 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptideActivated PDGFR interacts with GAP. This interaction was modeled on a demonstrated interaction between human PDGFR and canine GAP.BIND2157284 
N-terminal SH2 domain of GAP interacts with PDGFR. This interaction was modeled on a demonstrated interaction between GAP from human and PDGFR from an unspecified species.BIND1385407 |2173144 
|7689724 |8344248 
-HPRD,BioGRID10697503 |11896619 
Autophosphorylated PDGFR interacts with GAP. This interaction was modelled on a demonstrated interaction between human PDGFR and GAP from an unspecified species.BIND8890167 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD1336372 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Affinity Capture-WesternBioGRID9743338 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID8798684 |10708762 
|10713673 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD8570203 
PXNFLJ16691paxillin-HPRD,BioGRID10092539 
RAB5ARAB5RAB5A, member RAS oncogene family-HPRD11536198 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyin vivoBioGRID2164710 
SLC9A2NHE2solute carrier family 9 (sodium/hydrogen exchanger), member 2-HPRD,BioGRID10187839 
SOCS3ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3suppressor of cytokine signaling 3-HPRD,BioGRID11331873 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID1717825 
SYN1SYN1a | SYN1b | SYNIsynapsin I-HPRD,BioGRID10899172 
WWP1AIP5 | DKFZp434D2111 | Tiul1 | hSDRP1WW domain containing E3 ubiquitin protein ligase 1-HPRD9169421 
WWP2AIP2 | WWp2-likeWW domain containing E3 ubiquitin protein ligase 2-HPRD9169421 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1-HPRD,BioGRID1544885 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD,BioGRID7760813 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY 2116All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
BIOCARTA_TPO_PATHWAY 2417All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_AURORA_B_PATHWAY 3924All SZGR genes in this pathway
PID_INSULIN_PATHWAY 4532All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_VEGFR1_PATHWAY 2623All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_AURORA_A_PATHWAY 3120All SZGR genes in this pathway
PID_RAS_PATHWAY 3022All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_UP 5839All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
SCHRAMM_INHBA_TARGETS_DN 2412All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER 10062All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_UP 3825All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
ROSS_AML_OF_FAB_M7_TYPE 6844All SZGR genes in this pathway
GRANDVAUX_IRF3_TARGETS_DN 1914All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
PARK_HSC_MARKERS 4431All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C1 2414All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C5 4636All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_DN 6746All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
GYORFFY_MITOXANTRONE_RESISTANCE 5735All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2061051121A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-132/212473479m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-145415421m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-1531251321A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1823343411A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-211791851Ahsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-2233773841A,m8hsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-24238244m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-30-5p7007071A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3178851A,m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-3206206271A,m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3357682m8hsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-342118124m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-3745175231Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-3763673731Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-377117123m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-4481261321Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-5055835891Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-963353411Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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