Gene Page: BMP4

Summary
GeneID  652
Symbol  BMP4
Synonyms  BMP2B|BMP2B1|MCOPS6|ZYME
Description  bone morphogenetic protein 4
See related  HGNC:1071|MIM:112262|Ensembl:ENSG00000125378|HPRD:00207|
Locus tag  -
Gene type  protein-coding
Map location  14q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CHST50.580.67
MIB20.580.57
SLC25A280.570.59
DVL10.570.58
BX927359.10.570.61
TMEM1750.570.60
DNAJB20.560.62
C14orf800.550.59
AMDHD20.550.58
PNPLA20.550.61
Top 10 negatively co-expressed genes
RPS4Y1-0.30-0.28
AF347015.21-0.30-0.14
GNG11-0.29-0.25
USP9Y-0.29-0.28
CLEC2B-0.29-0.13
IL32-0.28-0.26
AC137766.1-0.27-0.16
ZFY-0.27-0.26
PRKY-0.27-0.29
CYorf15A-0.27-0.27
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS9804553 
GO:0005125cytokine activityIDA14749725 
GO:0005515protein bindingIEA-
GO:0008201heparin bindingIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0021978telencephalon regionalizationIEABrain (GO term level: 10)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0001525angiogenesisIEA-
GO:0001658ureteric bud branchingIEA-
GO:0001934positive regulation of protein amino acid phosphorylationIDA14749725 
GO:0007281germ cell developmentIEA-
GO:0007507heart developmentIEA-
GO:0007500mesodermal cell fate determinationIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0021904dorsoventral neural tube patterningIEA-
GO:0030501positive regulation of bone mineralizationIDA14749725 
GO:0030509BMP signaling pathwayIEA-
GO:0051216cartilage developmentIEA-
GO:0030218erythrocyte differentiationIEA-
GO:0043010camera-type eye developmentIEA-
GO:0032331negative regulation of chondrocyte differentiationIEA-
GO:0051145smooth muscle cell differentiationIEA-
GO:0030324lung developmentIEA-
GO:0040007growthIEA-
GO:0045165cell fate commitmentIEA-
GO:0045662negative regulation of myoblast differentiationIDA14749725 
GO:0045843negative regulation of striated muscle developmentIDA14749725 
GO:0045786negative regulation of cell cycleIDA11502704 
GO:0045669positive regulation of osteoblast differentiationIDA14749725 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixIEA-
GO:0005615extracellular spaceIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMP4BMP2B | BMP2B1 | MCOPS6 | ZYMEbone morphogenetic protein 4-HPRD7673243 
BMP4 forms homo-dimer. This interaction was modeled on a demonstrated interaction using BMP4 from an unspecified species.BIND15775969 
BMP8BBMP8 | MGC131757 | OP2bone morphogenetic protein 8b-HPRD10894154 |11427739 
BMPERCRIM3 | CV-2 | CV2BMP binding endothelial regulator-HPRD12897139 
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IA-HPRD8702914 |11241215 
Reconstituted ComplexBioGRID8006002 
BMPR1BALK-6 | ALK6 | CDw293bone morphogenetic protein receptor, type IB-HPRD7811286 |8702914 
|11282024 
Reconstituted ComplexBioGRID8006002 
BMP4 interacts with BMPR1B (BR). This interaction was modeled on a demonstrated interaction between BMP4 from an unspecified species and BMPR1B from an unspecified species.BIND15775969 
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)-HPRD,BioGRID7644468 |8702914 
CHRDMGC133038chordinBMP4 interacts with an unspecified isoform of CHRD (Chd). This interaction was modeled on a demonstrated interaction between BMP4 from an unspecified species and CHRD from an unspecified species.BIND15775969 
NOGSYM1 | SYNS1noggin-HPRD10657699 
SOSTDC1CDA019 | DKFZp564D206 | ECTODIN | USAG1sclerostin domain containing 1-HPRD,BioGRID15020244 
STAP2BKS | FLJ20234signal transducing adaptor family member 2-HPRD7644468 
TWSG1TSGtwisted gastrulation homolog 1 (Drosophila)Reconstituted ComplexBioGRID11260715 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN 182111All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_DN 6135All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP 7347All SZGR genes in this pathway
DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_DN 3627All SZGR genes in this pathway
GROSS_ELK3_TARGETS_UP 2716All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN 10371All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
RANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_UP 55All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_6HR 5938All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP 5233All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_UP 7848All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_DN 4731All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
NIELSEN_GIST_AND_SYNOVIAL_SARCOMA_UP 2015All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
ENGELMANN_CANCER_PROGENITORS_DN 7044All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN 228114All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
MATZUK_EMBRYONIC_GERM_CELL 1916All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_UP 7940All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G6_UP 6543All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1 6850All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-3631942011A,m8hsa-miR-363AUUGCACGGUAUCCAUCUGUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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