Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | CACNA1C |
|---|---|
| DrugBank ID | DB00653 |
| Drug Name | Magnesium sulfate |
| Target ID | BE0008715 |
| UniProt ID | O00555 |
| Regulation Type | inhibitor |
| PubMed IDs | 16157690; 11300616; 8410712; 26422671; 19933511 |
| Citations | Brunet S, Scheuer T, Klevit R, Catterall WA: Modulation of CaV1.2 channels by Mg2+ acting at an EF-hand motif in the COOH-terminal domain. J Gen Physiol. 2005 Oct;126(4):311-23. doi: 10.1085/jgp.200509333. Epub 2005 Sep 12.@@Bara M, Guiet-Bara A: Magnesium regulation of Ca2+ channels in smooth muscle and endothelial cells of human allantochorial placental vessels. Magnes Res. 2001 Mar;14(1-2):11-8.@@Kuo CC, Hess P: Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells. J Physiol. 1993 Jul;466:683-706.@@Zhao M, Feng R, Shao D, Liu S, Lei M, Wang H, Sun X, Guo F, Hu H, Kameyama M, Hao L: Mg(2+)-dependent facilitation and inactivation of L-type Ca(2+) channels in guinea pig ventricular myocytes. J Pharmacol Sci. 2015 Nov;129(3):143-9. doi: 10.1016/j.jphs.2015.08.001. Epub 2015 Aug 7.@@Lin CY, Tsai PS, Hung YC, Huang CJ: L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. Br J Anaesth. 2010 Jan;104(1):44-51. doi: 10.1093/bja/aep336. |
| Groups | Approved; Investigational; Vet_approved |
| Direct Classification | Alkaline earth metal sulfates |
| SMILES | [Mg++].[O-]S([O-])(=O)=O |
| Pathways | |
| PharmGKB | PA450302 |
| ChEMBL | CHEMBL2021423 |
