Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA1C |
|---|---|
| DrugBank ID | DB09227 |
| Drug Name | Barnidipine |
| Target ID | BE0000430 |
| UniProt ID | Q13936 |
| Regulation Type | antagonist |
| PubMed IDs | 7760349; 19416978; 11022040 |
| Citations | Kwan YW, Bangalore R, Lakitsh M, Glossmann H, Kass RS: Inhibition of cardiac L-type calcium channels by quaternary amlodipine: implications for pharmacokinetics and access to dihydropyridine binding site. J Mol Cell Cardiol. 1995 Jan;27(1):253-62.@@Tikhonov DB, Zhorov BS: Structural model for dihydropyridine binding to L-type calcium channels. J Biol Chem. 2009 Jul 10;284(28):19006-17. doi: 10.1074/jbc.M109.011296. Epub 2009 May 5.@@Yamaguchi S, Okamura Y, Nagao T, Adachi-Akahane S: Serine residue in the IIIS5-S6 linker of the L-type Ca2+ channel alpha 1C subunit is the critical determinant of the action of dihydropyridine Ca2+ channel agonists. J Biol Chem. 2000 Dec 29;275(52):41504-11. doi: 10.1074/jbc.M007165200. |
| Groups | Experimental |
| Direct Classification | Dihydropyridinecarboxylic acids and derivatives |
| SMILES | COC(=O)C1=C(C)NC(C)=C([C@H]1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)O[C@H]1CCN(CC2=CC=CC=C2)C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2103761 |
