| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20056727 | HPV | ENSG00000144852.20 | protein_coding | NR1I2 | No | No | 8856 | O75469 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NR1I2 |
|---|---|
| DrugBank ID | DB00783 |
| Drug Name | Estradiol |
| Target ID | BE0000956 |
| UniProt ID | O75469 |
| Regulation Type | binder |
| PubMed IDs | 17327420; 23884115; 26417296 |
| Citations | Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR: Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Mol Endocrinol. 2007 May;21(5):1028-38. Epub 2007 Feb 27.@@Banerjee M, Robbins D, Chen T: Modulation of xenobiotic receptors by steroids. Molecules. 2013 Jun 24;18(7):7389-406. doi: 10.3390/molecules18077389.@@Wang J, Dai S, Guo Y, Xie W, Zhai Y: Biology of PXR: role in drug-hormone interactions. EXCLI J. 2014 Jul 7;13:728-39. eCollection 2014. |
| Groups | Approved; Investigational; Vet_approved |
| Direct Classification | Estrogens and derivatives |
| SMILES | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3 |
| Pathways | Estrone Metabolism; Aromatase Deficiency; Androgen and Estrogen Metabolism; 17-beta Hydroxysteroid Dehydrogenase III Deficiency |
| PharmGKB | PA449503 |
| ChEMBL | CHEMBL135 |
