| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20056727 | HPV | ENSG00000144852.20 | protein_coding | NR1I2 | No | No | 8856 | O75469 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NR1I2 |
|---|---|
| DrugBank ID | DB01220 |
| Drug Name | Rifaximin |
| Target ID | BE0000956 |
| UniProt ID | O75469 |
| Regulation Type | agonist |
| PubMed IDs | 20627999; 17442842 |
| Citations | Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ: Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. J Pharmacol Exp Ther. 2010 Oct;335(1):32-41. doi: 10.1124/jpet.110.170225. Epub 2010 Jul 13.@@Ma X, Shah YM, Guo GL, Wang T, Krausz KW, Idle JR, Gonzalez FJ: Rifaximin is a gut-specific human pregnane X receptor activator. J Pharmacol Exp Ther. 2007 Jul;322(1):391-8. Epub 2007 Apr 18. |
| Groups | Approved; Investigational |
| Direct Classification | Macrolactams |
| SMILES | CO[C@H]1C=CO[C@@]2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C1=C(N=C5C=C(C)C=CN15)C4=C3C2=O |
| Pathways | |
| PharmGKB | PA164752443 |
| ChEMBL | CHEMBL1617 |
