Gene: SLCO3A1

28232
OATP-D|OATP-RP3|OATP3A1|OATPD|OATPRP3|SLC21A11
solute carrier organic anion transporter family member 3A1
protein-coding
15q26.1
Ensembl:ENSG00000176463 MIM:612435 Vega:OTTHUMG00000149846 UniprotKB:Q9UIG8
NC_000015.10
PubMed|SNP Mapped
8   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.319e-1 (AD)  9.112e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12910142chr15:92080273 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs7173864chr15:92067237 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs4932598chr15:91994615 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs4932597chr15:91994387 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs12439765chr15:91992372 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs12439738chr15:91992321 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs7163369chr15:91990684 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4075845chr15:91854794 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19687529chr15:92687777SLCO3A1Gene body4.869e-4Alcohol use disorders26763658
cg14295110chr15:92395641SLCO3A11.500e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTN20.909
CDR2L0.894
PXK0.881
JAM30.879
FAM124A0.869
AMOTL20.862
ABCA20.857
PIK3C2B0.853
NXPE30.849
CDK180.847

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.423
OR4F29-0.416
RNF43-0.316
OR4F16-0.293
DIO2-0.286
PON3-0.28
HKDC1-0.275
EYA1-0.273
FREM2-0.266
KCNJ16-0.264

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00345Aminohippuric acidSmall Molecule61-78-9Approved|InvestigationalTransporter
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00770AlprostadilSmall Molecule745-65-3Approved|InvestigationalTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB01053BenzylpenicillinSmall Molecule61-33-6ApprovedTransporter
DB01088IloprostSmall Molecule78919-13-8Approved|InvestigationalTransporter
DB01160Dinoprost TromethamineSmall Molecule38562-01-5ApprovedTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB06654SafinamideSmall Molecule133865-89-1Approved|InvestigationalTransporter
DB09198LobeglitazoneSmall Molecule607723-33-1Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SLCO3A1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SLCO3A1 mRNA]28655636
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLCO3A1 mRNA"15919853
C4879483-iodothyronamineSLCO3A1 mRNA affects the uptake of 3-iodothyronamine19074582
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLCO3A1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of SLCO3A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLCO3A1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLCO3A1 mRNA24449571
D001151ArsenicArsenic affects the methylation of SLCO3A1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of SLCO3A1 mRNA15761015
C015001arsenitearsenite results in increased methylation of SLCO3A1 promoter23974009
D017639Asbestos, Amosite"Asbestos, Amosite results in decreased expression of SLCO3A1 mRNA"23917077
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of SLCO3A1 mRNA"23917077
D001280AtrazineAtrazine results in decreased expression of SLCO3A1 mRNA25929836
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of SLCO3A1 mRNA15919853
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLCO3A1 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLCO3A1 mRNA"19150397
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SLCO3A1 mRNA17404688
C006780bisphenol Abisphenol A affects the expression of SLCO3A1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLCO3A1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLCO3A1 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SLCO3A1 mRNA18353800
D003471CuprizoneCuprizone results in decreased expression of SLCO3A1 mRNA27523638
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SLCO3A1 mRNA22579952
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SLCO3A1 protein22579952
D016572CyclosporineCyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]28887287
D016572CyclosporineCyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
D003907DexamethasoneDexamethasone results in increased expression of SLCO3A1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SLCO3A1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLCO3A1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLCO3A1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLCO3A1 mRNA22023808
D004237DiuronDiuron results in decreased expression of SLCO3A1 mRNA21551480
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of SLCO3A1 mRNA19118595
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLCO3A1 mRNA22079256
C017296estrone sulfateestrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
D005419FlavonoidsFlavonoids results in decreased expression of SLCO3A1 mRNA18035473
D019793FluoresceinCyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]28887287
D019793Fluoresceinsimvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]28887287
D019793FluoresceinSLCO3A1 protein results in increased uptake of Fluorescein28887287
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLCO3A1 gene20938992
D004397FonofosFonofos results in decreased methylation of SLCO3A1 promoter22847954
D017313FenretinideFenretinide results in decreased expression of SLCO3A1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SLCO3A1 mRNA28973697
D007200IndicanIndican promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
D007545IsoproterenolIsoproterenol results in increased expression of SLCO3A1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLCO3A1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of SLCO3A1 protein17337753
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SLCO3A1 mRNA"24972896
C018091maduramicinmaduramicin results in decreased expression of SLCO3A1 mRNA29128925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLCO3A1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLCO3A1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLCO3A1 mRNA"20188158
C500085muraglitazarmuraglitazar results in decreased expression of SLCO3A1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLCO3A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLCO3A1 mRNA"25554681|2562005
D010278ParathionParathion results in decreased methylation of SLCO3A1 promoter22847954
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SLCO3A1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of SLCO3A1 mRNA28655636
D010400Penicillin GPenicillin G promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLCO3A1 mRNA28143724
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SLCO3A1 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLCO3A1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLCO3A1 mRNA22079256
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SLCO3A1 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLCO3A1 mRNA24780913
C089730rosiglitazonerosiglitazone results in decreased expression of SLCO3A1 mRNA21515302
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLCO3A1 mRNA23221170
C063287simvastatin acidCyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
C063287simvastatin acidestrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
C063287simvastatin acidIndican promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
C063287simvastatin acidPenicillin G promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]28887287
C063287simvastatin acidsimvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]28887287
C063287simvastatin acidsimvastatin acid results in decreased expression of SLCO3A1 protein28887287
C063287simvastatin acidSLCO3A1 protein results in increased uptake of simvastatin acid28887287
C017947sodium arsenitesodium arsenite results in decreased expression of SLCO3A1 mRNA22714537
C012568terbufosterbufos results in decreased methylation of SLCO3A1 promoter22847954
C501413tesaglitazartesaglitazar results in decreased expression of SLCO3A1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLCO3A1 mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SLCO3A1 mRNA28973375
D014050TolueneToluene affects the expression of SLCO3A1 mRNA18653662
D014212TretinoinTretinoin results in decreased expression of SLCO3A1 mRNA16604517
C057693troglitazonetroglitazone results in decreased expression of SLCO3A1 mRNA21515302
C022884undecaneundecane results in decreased expression of SLCO3A1 protein17337753
D014635Valproic AcidValproic Acid affects the expression of SLCO3A1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SLCO3A1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of SLCO3A1 mRNA19101580|2317975
D014640VancomycinVancomycin results in decreased expression of SLCO3A1 mRNA18930951
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SLCO3A1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SLCO3A1 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLCO3A1 gene25560391
C025643vinclozolinvinclozolin affects the expression of SLCO3A1 mRNA23034163
C088658zoledronic acidzoledronic acid results in decreased expression of SLCO3A1 mRNA20977926
C088658zoledronic acidzoledronic acid results in increased expression of SLCO3A1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015347sodium-independent organic anion transmembrane transporter activity-IBA21873635  
GO:0015347sodium-independent organic anion transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015732prostaglandin transport-IBA21873635  
GO:0043252sodium-independent organic anion transport-IBA21873635  
GO:0043252sodium-independent organic anion transport-TAS-  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-879518Transport of organic anionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (2012 Aug 1)Wang KSDrug Alcohol Depend
24665060Genome-wide association study of smoking behaviours among Bangladeshi adults. (2014 May)Argos MJ Med Genet
19330903Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. (2009 Mar)Montasser MEJ Hypertens