Gene: SLC9A9

285195
AUTS16|NHE9
solute carrier family 9 member A9
protein-coding
3q24
Ensembl:ENSG00000181804 MIM:608396 Vega:OTTHUMG00000159373 UniprotKB:Q8IVB4
NG_017077.1
PubMed|SNP Mapped
11   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.179e-1 (AD)  5.073e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4839669chr3:143823101 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs1992864chr3:143687600 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs9289666chr3:143526140 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs838621chr3:143469211 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs838610chr3:143459684 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1723034chr3:143458406 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs868702chr3:143366503 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6775025chr3:143350462 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs10446322chr3:143349408 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7431637chr3:143330927 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7639109chr3:143275352 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMBIM10.836
NPC20.834
PLIN30.823
CYP27A10.82
CPQ0.819
WASF20.819
NFE2L20.819
PTTG1IP0.817
TTC380.817
MAGT10.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
F7-0.487
ADRA1D-0.485
FBLN7-0.479
VGF-0.476
ABCC12-0.465
PPEF1-0.459
SPON2-0.458
TPBGL-0.457
MARCH4-0.451
HTR6-0.436

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of SLC9A9 protein26194647
C4879483-iodothyronamineSLC9A9 mRNA affects the uptake of 3-iodothyronamine19074582
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC9A9 mRNA19038236
D000082AcetaminophenAcetaminophen results in decreased expression of SLC9A9 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC9A9 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC9A9 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of SLC9A9 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC9A9 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC9A9 mRNA20713471
C006780bisphenol Abisphenol A results in increased expression of SLC9A9 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of SLC9A9 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of SLC9A9 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC9A9 mRNA17484886
D016572CyclosporineCyclosporine results in increased expression of SLC9A9 mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of SLC9A9 mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of SLC9A9 mRNA25047013
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC9A9 mRNA26159488
D005978GlutathioneGlutathione deficiency results in increased expression of SLC9A9 mRNA20621112
D017313FenretinideFenretinide results in decreased expression of SLC9A9 mRNA28973697
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of SLC9A9 mRNA20843944
D008727MethotrexateMethotrexate affects the expression of SLC9A9 mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SLC9A9 mRNA20713471
C028007nickel monoxidenickel monoxide results in increased expression of SLC9A9 mRNA19167457
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of SLC9A9 mRNA28973697
D011192Potassium DichromatePotassium Dichromate results in increased expression of SLC9A9 mRNA23608068
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC9A9 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC9A9 mRNA23221170
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC9A9 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC9A9 mRNA20106945|2615948
C057693troglitazonetroglitazone results in increased expression of SLC9A9 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of SLC9A9 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC9A9 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC9A9 gene25560391
D014750VincristineVincristine results in increased expression of SLC9A9 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24705354  
GO:0015385sodium:proton antiporter activity-IBA21873635  
GO:0015385sodium:proton antiporter activity-TAS-  
GO:0015386potassium:proton antiporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0098719sodium ion import across plasma membrane-IBA21873635  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0031902late endosome membrane-TAS-  
GO:0055037recycling endosome-IBA21873635  
GO:0055037recycling endosome-IDA15522866  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425986Sodium/Proton exchangersTAS
R-HSA-5619052Defective SLC9A9 causes autism 16 (AUTS16)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19268276Genome-wide association study of smoking initiation and current smoking. (2009 Mar)Vink JMAm J Hum Genet
25129674Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)McClintick JNAlcohol