| Tag | Content |
|---|---|
| Uniprot ID | A0A0R4IQY2 |
| Entrez ID | 100334830 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_009302082.2 |
| Ensembl protein ID | ENSDARP00000138330 |
| Ensembl nucleotide ID | ENSDARG00000099546 |
| Gene name | Kynureninase |
| Gene symbol | kynu |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. |
| Sequence | MMERILSVCE KLKCSPTSPT LAEHLDQRDH LRHLRELFII PKTSQLSKVD LSLVDSSEDC 60 IYFAGNSLGL QPKNTKKYID EELEKWAKTG VHGHTEGSRP WAWAEETLEE MMAKIVGAKT 120 EEVALMNGLT VNLHLLMLSF YKPTPKRHKI LLEDKAFPSD HYAIESQIRL RGLNMSDSML 180 IIKPRQGEDV IRTEDIVSLI EREGESIALV MLSGVQYYSG QLFDMETITT AGHSKGCFVG 240 FDCAHAVGNA ELRLHDWNVD FACWCTYKYM NSGAGGLAGA YIHERHAHSI KPALTGWWGH 300 DLKTRFLMNN EMDLQPGVNG FRLSNQPILL VCPLQASLEI FNQTTMKDLR SKSVLLTAYL 360 EFLIRHYYSR DPSDPDRPSV HIITPSDPQQ RGCQLSLSFS SPIRAVFEEL EKRGVACDMR 420 EPNVLRVAPV PLYNSFTDVH RFITVLGSAL SASRQ 455 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KYNU | 520327 | F1MCH2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 102191655 | A0A452G451 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 8942 | Q16719 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 70789 | Q9CXF0 | CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KYNU | 459641 | H2QIS6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KYNU | A0A286ZLN5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | KYNU | 100352837 | G1SQI7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 116682 | P70712 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kynu | 100334830 | A0A0R4IQY2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0061981 | 3-hydroxykynureninase activity |
| GO:0030429 | kynureninase activity |
| GO:0030170 | pyridoxal phosphate binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0097053 | L-kynurenine catabolic process |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0019441 | tryptophan catabolic process to kynurenine |
| Pfam ID | Pfam Term |
|---|---|
| PF00266 | Aminotran_5 |