| Tag | Content |
|---|---|
| Uniprot ID | A0A286ZLN5 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000032485 |
| Ensembl nucleotide ID | ENSSSCG00000015673 |
| Gene name | Kynureninase |
| Gene symbol | KYNU |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Sequence | MESSPLELPA DTLQRIASEL RCHPTDERVA LRLDEEDEMK HFRECFYIPK KQDLPPIDLS 60 LVDKDEDAIY FLGNSLGLQP KMVKTYLEEE LDKWAKMGAY GHEVGKRPWI IGDEVILGLM 120 TDIVGANEKE IALMNGLTLN LHLLLLSFFK PTTKRYKILL EAKAFPSDHY AVESQLQLHG 180 LQVEKSMRII EPREGEETLR MEDIIEVIEN EGDSIAVILF SGVHFYTGQL FNIPAITKAG 240 QAKGCFVGFD LAHAVGNVEL YLHDWGVDFA CWCSYKYLNS GAGGLAGAFV HEKHAYTIKP 300 TLVGWFGHEL STRFKMDNKL QLIPGVTGFR ISNPPILLVC PLHASLEIFK QATMKALRRK 360 SILLTGYLEY MIKQYYSQDK AETKKTVVNI ITPSSIEDRG CQLTLTFSVP MKQVFQELEK 420 RGVVCDKREP NGIRVAPVPL YNSFHDVYKF INLLTSVLDS AESKK 465 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KYNU | 520327 | F1MCH2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 102191655 | A0A452G451 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 8942 | Q16719 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 70789 | Q9CXF0 | CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KYNU | 459641 | H2QIS6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KYNU | A0A286ZLN5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | KYNU | 100352837 | G1SQI7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 116682 | P70712 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kynu | 100334830 | A0A0R4IQY2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0030429 | kynureninase activity |
| GO:0030170 | pyridoxal phosphate binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0097053 | L-kynurenine catabolic process |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0006569 | tryptophan catabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF00266 | Aminotran_5 |