| Tag | Content |
|---|---|
| Uniprot ID | G1SQI7 |
| Entrez ID | 100352837 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002712137.3 |
| Ensembl protein ID | ENSOCUP00000005365 |
| Ensembl nucleotide ID | ENSOCUG00000006194 |
| Gene name | Kynureninase |
| Gene symbol | KYNU |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Sequence | MEPSPLELPA DTVQRIAAAL QCHPTDERVA LYLDEKDELK HFRDYFYIPK MKDLPPIDLS 60 LVNKDENAIY FLGNSLGLQP KMVKTYLEEE LDKWAKMGAY GHDVGKRPWI TGDECIVGLM 120 EDIVGANEKE IALMNALTVN LHLLLLSFFK PTPKRHKILL EAKAFPSDHY AIESQLQLHG 180 LNVEKSMRII KPREGEEILR MEDILEVIEK EGDSIAVILF SGVHFYSGQL LDMPAITKAG 240 QAKGCFVGFD LAHAVGNVEL HLHDWGVDFA CWCSYKYLNS GAGGLAGAFV HEKHTHTIRP 300 ALVGWFGHEL STRFEMDNKL QLIPGVTGFR ISNPPILLVC SLHASLEIFK KATMKALRRK 360 SILLTGYLEY MIKQYYHKDK AETNESIVNI ITPSRIEDRG CQLTLTFTVP KKNVFQELEK 420 RGVVCDKREP NGIRVAPVPL YNSFHDVYKF VTLLTSVLDC TQTK 464 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KYNU | 520327 | F1MCH2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 102191655 | A0A452G451 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 8942 | Q16719 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 70789 | Q9CXF0 | CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KYNU | 459641 | H2QIS6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KYNU | A0A286ZLN5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | KYNU | 100352837 | G1SQI7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 116682 | P70712 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kynu | 100334830 | A0A0R4IQY2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0030429 | kynureninase activity |
| GO:0030170 | pyridoxal phosphate binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0097053 | L-kynurenine catabolic process |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0006569 | tryptophan catabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF00266 | Aminotran_5 |