Gene: Kynu

Basic information

Tag Content
Uniprot ID Q9CXF0
Entrez ID 70789
Genbank protein ID BAB29386.2; BAC34035.1;
Genbank nucleotide ID NM_001289594.1; NM_001289593.1; XM_006498325.3; NM_027552.2;
Ensembl protein ID
Ensembl nucleotide ID
Gene name Kynureninase
Gene symbol Kynu
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CLP,CLO
Developmental stage
Data sources Manually collected
Reference 23469164
Functional description Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Sequence
MEPSPLELPV DAVRRIAAEL NCDPTDERVA LRLDEEDKLS HFRNCFYIPK MRDLPSIDLS 60
LVSEDDDAIY FLGNSLGLQP KMVRTYLEEE LDKWAKMGAY GHDVGKRPWI VGDESIVSLM 120
KDIVGAHEKE IALMNALTIN LHLLLLSFFK PTPKRHKILL EAKAFPSDHY AIESQIQLHG 180
LDVEKSMRMV KPREGEETLR MEDILEVIEE EGDSIAVILF SGLHFYTGQL FNIPAITKAG 240
HAKGCFVGFD LAHAVGNVEL RLHDWGVDFA CWCSYKYLNS GAGGLAGAFV HEKHAHTVKP 300
ALVGWFGHDL STRFNMDNKL QLIPGANGFR ISNPPILLVC SLHASLEVFQ QATMTALRRK 360
SILLTGYLEY MLKHYHSKDN TENKGPIVNI ITPSRAEERG CQLTLTFSIP KKSVFKELEK 420
RGVVCDKREP DGIRVAPVPL YNSFHDVYKF IRLLTSILDS SERS 464

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologKYNU520327F1MCH2Bos taurusPredictionMore>>
1:1 orthologKYNU102191655A0A452G451Capra hircusPredictionMore>>
1:1 orthologKYNU8942Q16719Homo sapiensPredictionMore>>
1:1 orthologKynu70789Q9CXF0CLP,CLOMus musculusPublicationMore>>
1:1 orthologKYNU459641H2QIS6Pan troglodytesPredictionMore>>
1:1 orthologKYNUA0A286ZLN5Sus scrofaPredictionMore>>
1:1 orthologKYNU100352837G1SQI7Oryctolagus cuniculusPredictionMore>>
1:1 orthologKynu116682P70712Rattus norvegicusPredictionMore>>
1:1 orthologkynu100334830A0A0R4IQY2Danio rerioPredictionMore>>

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0030170 pyridoxal phosphate bindingISO
GO:0030429 kynureninase activityISO
GO:0030429 kynureninase activityIBA
GO:0042803 protein homodimerization activityISO
GO:0061981 3-hydroxykynureninase activityISS
GO:0061981 3-hydroxykynureninase activityISO

GO:Biological Process

GO ID GO Term Evidence
GO:0006569 tryptophan catabolic processISO
GO:0009435 NAD biosynthetic processISS
GO:0009435 NAD biosynthetic processISO
GO:0019441 tryptophan catabolic process to kynurenineIBA
GO:0019442 tryptophan catabolic process to acetyl-CoAISO
GO:0019805 quinolinate biosynthetic processISO
GO:0034341 response to interferon-gammaISO
GO:0034354 'de novo' NAD biosynthetic process from tryptophanIEA
GO:0034516 response to vitamin B6ISO
GO:0043420 anthranilate metabolic processISO
GO:0043420 anthranilate metabolic processIBA
GO:0097053 L-kynurenine catabolic processIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmISO
GO:0005737 cytoplasmIBA
GO:0005739 mitochondrionISO
GO:0005739 mitochondrionHDA
GO:0005829 cytosolISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-71240 Tryptophan catabolismIEA
R-MMU-71291 Metabolism of amino acids and derivativesIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0963 Cytoplasm
KW-0378 Hydrolase
KW-0662 Pyridine nucleotide biosynthesis
KW-0663 Pyridoxal phosphate
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00266 Aminotran_5

Protein-miRNA interaction