Gene: KYNU

Basic information

Tag Content
Uniprot ID H2QIS6; A0A2J8PP37;
Entrez ID 459641
Genbank protein ID JAA38716.1; JAA19510.1;
Genbank nucleotide ID XM_515818.4; XM_003309266.4;
Ensembl protein ID ENSPTRP00000021398; ENSPTRP00000067734;
Ensembl nucleotide ID ENSPTRG00000012509
Gene name Kynureninase
Gene symbol KYNU
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Sequence
MEPSSVELPA DTVQRIAAEL KCHPTDERVA LHLDEEDKLR HFRECFYIPK IQDLPPVDLS 60
LVNKDENAIY FLGNSLGLQP KMVKTYLEEE LDKWAKIAAY GHEVGKRPWI TGDESIVGLM 120
KDIVGANEKE IALMNALTVN LHLLMLSFFK PTPKRYKILL EAKAFPSDHY AIESQLQLHG 180
LNIEESMRMI KPREGEETLR IEDILEVIEK EGDSIAVILF SGVHFYTGQH FNIPAITKAG 240
QAKGCYVGFD LAHAVGNVEL YLHDWGVDFA CWCSYKYLNA GAGGIAGAFI HEKHAHTIKP 300
ALVGWFGHEL STRFKMDNKL QLIPGVCGFR ISNPPILLVC SLHASLEIFK QATMKALRKK 360
SVLLTGYLEY LIKHNYGKDK AATKKPVVNI ITPSHVEERG CQLTITFSVP NKDVFQELEK 420
RGVVCDKRNP NGIRVAPVPL YNSFHDVYKF TNLLTSILDS AETTN 465

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologKYNU520327F1MCH2Bos taurusPredictionMore>>
1:1 orthologKYNU102191655A0A452G451Capra hircusPredictionMore>>
1:1 orthologKYNU8942Q16719Homo sapiensPredictionMore>>
1:1 orthologKynu70789Q9CXF0CLP,CLOMus musculusPublicationMore>>
1:1 orthologKYNU459641H2QIS6Pan troglodytesPredictionMore>>
1:1 orthologKYNUA0A286ZLN5Sus scrofaPredictionMore>>
1:1 orthologKYNU100352837G1SQI7Oryctolagus cuniculusPredictionMore>>
1:1 orthologKynu116682P70712Rattus norvegicusPredictionMore>>
1:1 orthologkynu100334830A0A0R4IQY2Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005739 mitochondrion
GO:0005654 nucleoplasm
GO:0061981 3-hydroxykynureninase activity
GO:0030429 kynureninase activity
GO:0042803 protein homodimerization activity
GO:0030170 pyridoxal phosphate binding
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 anthranilate metabolic process
GO:0097053 L-kynurenine catabolic process
GO:0019805 quinolinate biosynthetic process
GO:0034341 response to interferon-gamma
GO:0034516 response to vitamin B6
GO:0019441 tryptophan catabolic process to kynurenine

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0378 Hydrolase
KW-0662 Pyridine nucleotide biosynthesis
KW-0663 Pyridoxal phosphate
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00266 Aminotran_5