| Tag | Content |
|---|---|
| Uniprot ID | F1MCH2 |
| Entrez ID | 520327 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001191308.1 |
| Ensembl protein ID | ENSBTAP00000070357; ENSBTAP00000043129; |
| Ensembl nucleotide ID | ENSBTAG00000032277 |
| Gene name | Kynureninase |
| Gene symbol | KYNU |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Sequence | MEPSPLELPT DTLRRIASEL RCHPTDERVA LRLDEEDKLR HFRECFYIPK MQDLPPIDLS 60 LVNKDEEAIY FSGNSLGLQP KMVKTYLEEE LDKWAKMGAY GHSVGKRPWI IGDETISGLM 120 ADIVGANEKE IALMNGLTVN LHLLLLSFFK PTPKRYKILL EAKAFPSDHY AVESQLQLHG 180 LNIEKSMRII KPREGEDTLR LEDILEVIEN EGDSIAVILF SGLHFYTGQL FNIPAITKAG 240 QAKGCFVGFD LAHAVGNVEL HLHDWGVDFA CWCSYKYLNT GAGGLAGAFV HEKHAYTIKP 300 ALVGWFGHEL STRFQMDNKL QLIPGVNGFR ISNPPILLVC SLHASLEIFK QATMKALRRK 360 SILLTGYLEY MIKQYFSQDK AESKKTVVNI ITPSCIAERG CQLTLTFSIP IKHIIQELEK 420 RGVVCDKREP DGIRVAPVPL YNSFHDVYKF INLLTSVLGS VET 463 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KYNU | 520327 | F1MCH2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 102191655 | A0A452G451 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 8942 | Q16719 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 70789 | Q9CXF0 | CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KYNU | 459641 | H2QIS6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KYNU | A0A286ZLN5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | KYNU | 100352837 | G1SQI7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 116682 | P70712 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kynu | 100334830 | A0A0R4IQY2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0030429 | kynureninase activity |
| GO:0030170 | pyridoxal phosphate binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0097053 | L-kynurenine catabolic process |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0019441 | tryptophan catabolic process to kynurenine |
| Pfam ID | Pfam Term |
|---|---|
| PF00266 | Aminotran_5 |