| Tag | Content |
|---|---|
| Uniprot ID | P70712; Q68G25; Q7M0D0; Q9QW90; |
| Entrez ID | 116682 |
| Genbank protein ID | AAH78762.1; AAC53206.1; |
| Genbank nucleotide ID | NM_053902.2 |
| Ensembl protein ID | ENSRNOP00000050947 |
| Ensembl nucleotide ID | ENSRNOG00000029993 |
| Gene name | Kynureninase |
| Gene symbol | Kynu |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Sequence | MEPSPLELPV DAVRRIATEL NCDPTDERVA LRLDEEDKLK RFKDCFYIPK MRDLPSIDLS 60 LVNEDDNAIY FLGNSLGLQP KMVKTYLEEE LDKWAKIGAY GHEVGKRPWI IGDESIVSLM 120 KDIVGAHEKE IALMNALTVN LHLLLLSFFK PTPKRHKILL EAKAFPSDHY AIESQIQLHG 180 LDVEKSMRMI KPREGEETLR MEDILEVIEK EGDSIAVVLF SGLHFYTGQL FNIPAITQAG 240 HAKGCFVGFD LAHAVGNVEL HLHDWDVDFA CWCSYKYLNS GAGGLAGAFI HEKHAHTIKP 300 ALVGWFGHEL STRFNMDNKL QLIPGVNGFR ISNPPILLVC SLHASLEIFQ QATMTALRRK 360 SILLTGYLEY LLKHYHGGND TENKRPVVNI ITPSRAEERG CQLTLTFSIS KKGVFKELEK 420 RGVVCDKREP EGIRVAPVPL YNSFHDVYKF IRLLTAILDS TERN 464 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KYNU | 520327 | F1MCH2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 102191655 | A0A452G451 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KYNU | 8942 | Q16719 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 70789 | Q9CXF0 | CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KYNU | 459641 | H2QIS6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KYNU | A0A286ZLN5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | KYNU | 100352837 | G1SQI7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kynu | 116682 | P70712 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kynu | 100334830 | A0A0R4IQY2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0005739 | mitochondrion |
| GO:0005654 | nucleoplasm |
| GO:0061981 | 3-hydroxykynureninase activity |
| GO:0030429 | kynureninase activity |
| GO:0042803 | protein homodimerization activity |
| GO:0030170 | pyridoxal phosphate binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0007568 | aging |
| GO:0043420 | anthranilate metabolic process |
| GO:0097053 | L-kynurenine catabolic process |
| GO:0009435 | NAD biosynthetic process |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0034341 | response to interferon-gamma |
| GO:0034516 | response to vitamin B6 |
| GO:0006569 | tryptophan catabolic process |
| GO:0019442 | tryptophan catabolic process to acetyl-CoA |
| GO:0019441 | tryptophan catabolic process to kynurenine |
| Pfam ID | Pfam Term |
|---|---|
| PF00266 | Aminotran_5 |