| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3RNZ6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000066419 |
| Ensembl nucleotide ID | ENSPTRG00000015733 |
| Gene name | Tumor protein 63 (p63) |
| Gene symbol | TP63 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. |
| Sequence | ATCNIFVETP AHFSWKESYY RSTMSQSTQT NEFLSPEVFQ HIWDFLEQPI CSVQPIDLNF 60 VDEPSEDGAT NKIEISMDCI RMQDSDLSDP MWPQYTNLGL LNSMDQQIQN GSSSTSPYNT 120 DHAQNSVTAP SPYAQPSSTF DALSPSPAIP SNTDYPGPHS FDVSFQQSST AKSATWTYST 180 ELKKLYCQIA KTCPIQIKVM TPPPQGAVIR AMPVYKKAEH VTEVVKRCPN HELSREFNEG 240 QIAPPSHLIR VEGNSHAQYV EDPITGRQSV LVPYEPPQVG TEFTTVLYNF MCNSSCVGGM 300 NRRPILIIVT LETRDGQVLG RRCFEARICA CPGRDRKADE DSIRKQQVSD STKNGDGTKR 360 PFRQNTHGIQ MTSIKKRRSP DDELLYLPVR GRETYEMLLK IKESLELMQY LPQHTIETYR 420 QQQQQQHQHL LQKQTSIQSP SSYGNSSPPL NKMNSMNKLP SVSQLINPQQ RNALTPTTIP 480 DGMGANIPMM GTHMPMAGDM NGLSPTQALP PPLSMPSTSH CTPPPPYPTD CSIVSFLARL 540 GCSSCLDYFT TQGLTTIYQI EHYSMDDLAS LKIPEQFRHA IWKGILDHRQ LHEFSSPSHL 600 LRTPSSASTV SVGSSETRGE RVIDAVRFTL RQTISFPPRD EWNDFNFDMD ARRNKQQRIK 660 EEGE 664 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP63 | 615335 | F1MKA9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP63 | F1PL57 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A452FUS8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 8626 | Q9H3D4 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tp63 | 22061 | O88898 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP63 | A0A2I3RNZ6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A480T7V4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 100355881 | G1TBP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tp63 | 246334 | Q9JJP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tp63 | F1QLJ1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0046872 | metal ion binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0006915 | apoptotic process |
| GO:0032502 | developmental process |
| GO:0051262 | protein tetramerization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |