| Tag | Content |
|---|---|
| Uniprot ID | Q9JJP6; Q99JD6; Q99JD7; Q99JD8; Q99JD9; Q99JE0; Q99JE1; Q99JE2; Q99JE3; |
| Entrez ID | 246334 |
| Genbank protein ID | CAC37105.1; CAC37101.1; CAC37099.1; CAC37103.1; CAB88216.1; CAC37102.1; CAC37104.1; CAC37098.1; CAC37100.1; |
| Genbank nucleotide ID | NM_001127343.1; NM_019221.3; XM_008768791.2; NM_001127339.1; NM_001127344.1; NM_001127342.1; NM_001127341.1; |
| Ensembl protein ID | ENSRNOP00000033463; ENSRNOP00000061884; ENSRNOP00000002636; ENSRNOP00000032308; ENSRNOP00000059178; |
| Ensembl nucleotide ID | ENSRNOG00000001924 |
| Gene name | Tumor protein 63 |
| Gene symbol | Tp63 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity). |
| Sequence | MNFETSRCAT LQYCPDPYIQ RFIETPSHFS WKESYYRSAM SQSTQTSEFL SPEVFQHIWD 60 FLEQPICSVQ PIDLNFVDEP SENGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNGM 120 DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 180 FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 240 VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 300 TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 360 KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 420 LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ 480 LINPQQRNAL TPTTMPEGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 540 PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 600 ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 660 FNFDMDSRRN KQQRIKEEGE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP63 | 615335 | F1MKA9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP63 | F1PL57 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A452FUS8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 8626 | Q9H3D4 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tp63 | 22061 | O88898 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP63 | A0A2I3RNZ6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A480T7V4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 100355881 | G1TBP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tp63 | 246334 | Q9JJP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tp63 | F1QLJ1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0030425 | dendrite |
| GO:0043005 | neuron projection |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0032991 | protein-containing complex |
| GO:0005791 | rough endoplasmic reticulum |
| GO:0003682 | chromatin binding |
| GO:0003684 | damaged DNA binding |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0003690 | double-stranded DNA binding |
| GO:0042802 | identical protein binding |
| GO:0097371 | MDM2/MDM4 family protein binding |
| GO:0046872 | metal ion binding |
| GO:0002039 | p53 binding |
| GO:0019904 | protein domain specific binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0050699 | WW domain binding |
| GO:0007568 | aging |
| GO:0048646 | anatomical structure formation involved in morphogenesis |
| GO:0009887 | animal organ morphogenesis |
| GO:0007569 | cell aging |
| GO:0030154 | cell differentiation |
| GO:0008283 | cell population proliferation |
| GO:0006974 | cellular response to DNA damage stimulus |
| GO:0006338 | chromatin remodeling |
| GO:0060197 | cloacal septation |
| GO:1904888 | cranial skeletal system development |
| GO:0007499 | ectoderm and mesoderm interaction |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0009913 | epidermal cell differentiation |
| GO:0010481 | epidermal cell division |
| GO:0008544 | epidermis development |
| GO:0002064 | epithelial cell development |
| GO:0030855 | epithelial cell differentiation |
| GO:0001736 | establishment of planar polarity |
| GO:0061436 | establishment of skin barrier |
| GO:0048807 | female genitalia morphogenesis |
| GO:0001942 | hair follicle development |
| GO:0031069 | hair follicle morphogenesis |
| GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| GO:0030216 | keratinocyte differentiation |
| GO:0043616 | keratinocyte proliferation |
| GO:0001738 | morphogenesis of a polarized epithelium |
| GO:0010259 | multicellular organism aging |
| GO:0043066 | negative regulation of apoptotic process |
| GO:2000773 | negative regulation of cellular senescence |
| GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:2000381 | negative regulation of mesoderm development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0051402 | neuron apoptotic process |
| GO:0007219 | Notch signaling pathway |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0007389 | pattern specification process |
| GO:0030859 | polarized epithelial cell differentiation |
| GO:2001235 | positive regulation of apoptotic signaling pathway |
| GO:1902808 | positive regulation of cell cycle G1/S phase transition |
| GO:2000271 | positive regulation of fibroblast apoptotic process |
| GO:0010838 | positive regulation of keratinocyte proliferation |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0045747 | positive regulation of Notch signaling pathway |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:1904674 | positive regulation of somatic stem cell population maintenance |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0036342 | post-anal tail morphogenesis |
| GO:0030850 | prostate gland development |
| GO:0060513 | prostatic bud formation |
| GO:0051262 | protein tetramerization |
| GO:0009954 | proximal/distal pattern formation |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0010482 | regulation of epidermal cell division |
| GO:0001302 | replicative cell aging |
| GO:0001501 | skeletal system development |
| GO:0098773 | skin epidermis development |
| GO:0043589 | skin morphogenesis |
| GO:0048745 | smooth muscle tissue development |
| GO:0007283 | spermatogenesis |
| GO:0060529 | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development |
| GO:0048485 | sympathetic nervous system development |
| GO:0060157 | urinary bladder development |
| Keyword ID | Keyword Term |
|---|---|
| KW-0010 | Activator |
| KW-0877 | Alternative promoter usage |
| KW-0025 | Alternative splicing |
| KW-0053 | Apoptosis |
| KW-0217 | Developmental protein |
| KW-0238 | DNA-binding |
| KW-1017 | Isopeptide bond |
| KW-0479 | Metal-binding |
| KW-0914 | Notch signaling pathway |
| KW-0539 | Nucleus |
| KW-1185 | Reference proteome |
| KW-0804 | Transcription |
| KW-0805 | Transcription regulation |
| KW-0832 | Ubl conjugation |
| KW-0862 | Zinc |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |