| Tag | Content |
|---|---|
| Uniprot ID | F1MKA9 |
| Entrez ID | 615335 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001191337.1 |
| Ensembl protein ID | ENSBTAP00000020544 |
| Ensembl nucleotide ID | ENSBTAG00000015460 |
| Gene name | Tumor protein 63 (p63) |
| Gene symbol | TP63 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. |
| Sequence | MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTSEFL SPEVFQHIWD 60 FLEQPICSVQ PIDLNFVDEP SENGATNKIE ISMDCIRMQD SDLGDPMWPQ YTNLGLLNSM 120 DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 180 FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 240 VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 300 TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 360 KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 420 LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ 480 LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 540 PPYPTDCSLV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 600 ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 660 FNFDMDARRN KQQRIKEEGE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP63 | 615335 | F1MKA9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP63 | F1PL57 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A452FUS8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 8626 | Q9H3D4 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tp63 | 22061 | O88898 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP63 | A0A2I3RNZ6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A480T7V4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 100355881 | G1TBP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tp63 | 246334 | Q9JJP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tp63 | F1QLJ1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0003682 | chromatin binding |
| GO:0003684 | damaged DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0042802 | identical protein binding |
| GO:0097371 | MDM2/MDM4 family protein binding |
| GO:0046872 | metal ion binding |
| GO:0002039 | p53 binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0050699 | WW domain binding |
| GO:0007569 | cell aging |
| GO:0008283 | cell population proliferation |
| GO:0006338 | chromatin remodeling |
| GO:0060197 | cloacal septation |
| GO:1904888 | cranial skeletal system development |
| GO:0007499 | ectoderm and mesoderm interaction |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0010481 | epidermal cell division |
| GO:0002064 | epithelial cell development |
| GO:0001736 | establishment of planar polarity |
| GO:0061436 | establishment of skin barrier |
| GO:0048807 | female genitalia morphogenesis |
| GO:0031069 | hair follicle morphogenesis |
| GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| GO:0030216 | keratinocyte differentiation |
| GO:0010259 | multicellular organism aging |
| GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:2000381 | negative regulation of mesoderm development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0051402 | neuron apoptotic process |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0030859 | polarized epithelial cell differentiation |
| GO:2001235 | positive regulation of apoptotic signaling pathway |
| GO:2000271 | positive regulation of fibroblast apoptotic process |
| GO:0010838 | positive regulation of keratinocyte proliferation |
| GO:0045747 | positive regulation of Notch signaling pathway |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:1904674 | positive regulation of somatic stem cell population maintenance |
| GO:0036342 | post-anal tail morphogenesis |
| GO:0060513 | prostatic bud formation |
| GO:0051262 | protein tetramerization |
| GO:0009954 | proximal/distal pattern formation |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0010482 | regulation of epidermal cell division |
| GO:0001501 | skeletal system development |
| GO:0043589 | skin morphogenesis |
| GO:0060529 | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development |
| GO:0048485 | sympathetic nervous system development |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |