| Tag | Content |
|---|---|
| Uniprot ID | A0A480T7V4 |
| Entrez ID | |
| Genbank protein ID | HDB55453.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000064786 |
| Ensembl nucleotide ID | ENSSSCG00000025592 |
| Gene name | Tumor protein 63 (p63) |
| Gene symbol | TP63 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. |
| Sequence | MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTSEFL SPEVFQHIWD 60 FLEQPICSVQ PIDLNFVDEP SENGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 120 DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 180 FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 240 VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 300 TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 360 KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 420 LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ 480 LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 540 PPYPTDCSLV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 600 ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 660 FNFDMDARRN KQQRIKEEGE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP63 | 615335 | F1MKA9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP63 | F1PL57 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A452FUS8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 8626 | Q9H3D4 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tp63 | 22061 | O88898 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP63 | A0A2I3RNZ6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A480T7V4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 100355881 | G1TBP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tp63 | 246334 | Q9JJP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tp63 | F1QLJ1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0046872 | metal ion binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0006915 | apoptotic process |
| GO:0032502 | developmental process |
| GO:0051262 | protein tetramerization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |