| Tag | Content |
|---|---|
| Uniprot ID | F1QLJ1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000106582 |
| Ensembl nucleotide ID | ENSDARG00000044356 |
| Gene name | Cellular tumor antigen p53 |
| Gene symbol | tp63 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. |
| Sequence | MLYLETNAPS SYSEPQYTSL GLLNSMDQNG GSTSTSPYNN DHAQNNVTAP SPYAQPSSTF 60 EALSPSPAIP SNTDYAGPHT FDVSFQQSST AKSATWTYST ELKKLYCQIA KTCPIQIKVL 120 TNPPQGAVIR AMPVYKKAEH VTEVVKRCPN HELSREFNDG QIAPPSHLIR VEGNSHAQYV 180 EDSITGRQSV LVPYEPPQVG TEFTTILYNF MCNSSCVGGM NRRPILIIVT LETRDGQVLG 240 RRCFEARICA CPGRDRKADE DSIRKQHVTD GTKSSEGTKR PFRQASSHLS QLNSIKKRRS 300 TDEEVFCLPI KGREIYEILV KIKESLELMQ FLPQQTIESY RQQQQNLLQK QSSLPPQPAF 360 GSSSPTLGKN KLPSVSQLIN PQQRNALTPS GMPGGLTDMT PPMMGGPVPM NTDLSSLSPN 420 NPLQSQLQMV PSSHCTPPP 439 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP63 | 615335 | F1MKA9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP63 | F1PL57 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A452FUS8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 8626 | Q9H3D4 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tp63 | 22061 | O88898 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP63 | A0A2I3RNZ6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A480T7V4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 100355881 | G1TBP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tp63 | 246334 | Q9JJP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tp63 | F1QLJ1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046872 | metal ion binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0007049 | cell cycle |
| GO:0048730 | epidermis morphogenesis |
| GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0051262 | protein tetramerization |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |