| Tag | Content |
|---|---|
| Uniprot ID | A0A452FUS8 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000027979 |
| Ensembl nucleotide ID | ENSCHIG00000023662 |
| Gene name | Tumor protein 63 (p63) |
| Gene symbol | TP63 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. |
| Sequence | KSFNTVEMAT LTYVFSFFIL LRFVETPAHF SWKESYYRST MSQSTQTNEF LSPEVFQHIW 60 DFLEQPICSV QPIDLNFVDE PSENGATNKI EISMDCIRMQ DSDLSDPMWP QYTNLGLLNS 120 MDQQIQNGSS STSPYNTDHA QNSVTAPSPY AQPSSTFDAL SPSPAIPSNT DYPGPHSFDV 180 SFQQSSTAKS ATWTYSTELK KLYCQIAKTC PIQIKVMTPP PQGAVIRAMP VYKKAEHVTE 240 VVKRCPNHEL SREFNEGQIA PPSHLIRVEG NSHAQYVEDP ITGRQSVLVP YEPPQVGTEF 300 TTVLYNFMCN SSCVGGMNRR PILIIVTLET RDGQVLGRRC FEARICACPG RDRKADEDSI 360 RKQQVSDSTK NGDGTKRPFR QNTHGIQMTS IKKRRSPDDE LLYLPVRGRE TYEMLLKIKE 420 SLELMQYLPQ HTIETYRQQQ QQQHQHLLQK QTSMQSQSSY GNSSPPLNKM NSMNKLPSVS 480 QLINPQQRNA LTPTTIPDGM GANIPMMGTH MPMAGDMNGL SPTQALPPPL SMPSTSHCTP 540 PPPYPTDCSL VSFLARLGCS SCLDYFTTQG LTTIYQIEHY SMDDLASLKI PEQFRHAIWK 600 GILDHRQLHD FSSPPHLLRT PSGASTVSVG SSETRGERVI DAVRFTLRQT ISFPPRDEWN 660 DFNFDMDARR NKQQRIKEEG E 681 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.