| Tag | Content |
|---|---|
| Uniprot ID | G1TBP7 |
| Entrez ID | 100355881 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_008266647.2 |
| Ensembl protein ID | ENSOCUP00000014157 |
| Ensembl nucleotide ID | ENSOCUG00000016465 |
| Gene name | Tumor protein 63 (p63) |
| Gene symbol | TP63 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. |
| Sequence | MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 60 TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 120 VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 180 YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 240 LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSTKNGDGT KRPFRQNTHG IQMTSIKKRR 300 SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ HLLQKQTSMQ 360 SQSSYGNSSP PLNKMNSMNK LPSVSQLINP QQRNALTPTT IPDGMGANIP MMGTHMPMAG 420 DMNGLSPTQA LPPPLSMPST SHCTPPPPYP TDCSIVSFLA RLGCSSCLDY FTTQGLTTIY 480 QIEHYSMDDL ASLKIPEQFR HAIWKGILDH RQLHDFSSPP HLLRTPSGAS TVSVGSSETR 540 GERVIDAVRF TLRQTISFPP RDEWNDFNFD MDARRNKQQR IKEEGE 586 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP63 | 615335 | F1MKA9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP63 | F1PL57 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A452FUS8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 8626 | Q9H3D4 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tp63 | 22061 | O88898 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP63 | A0A2I3RNZ6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TP63 | A0A480T7V4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TP63 | 100355881 | G1TBP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tp63 | 246334 | Q9JJP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tp63 | F1QLJ1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0046872 | metal ion binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0006915 | apoptotic process |
| GO:0032502 | developmental process |
| GO:0051262 | protein tetramerization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |