Gene: CYP2E1

Basic information

Tag Content
Uniprot ID A0A452DL40
Entrez ID 102182294
Genbank protein ID
Genbank nucleotide ID XM_005701375.3
Ensembl protein ID ENSCHIP00000000561
Ensembl nucleotide ID ENSCHIG00000000393
Gene name Uncharacterized protein
Gene symbol CYP2E1
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAALGITVAL LVWMATLLLI SIWKHIYSSW KLPPGPFPLP IIGNLLQLDI KNIPKSFTRL 60
AERFGPVFTL YLGSRRVVVV HGYKPVKEVL LDYKNEFSGR GENPGFQVHK NNGIIFNNGP 120
TWRDTRRFSL TILRDLGMGK QGNEQRIQRE AHFLLDVLRK TQGQPFDPTF VIGFAPYNVI 180
SDILFHKRFD YKDKMGLRLM SLFNENFYLL STPWIQLYNN FSDYLQYLPG SHRKLLKNVS 240
EVKDYALERT KAHQKSLEPS CPRGFLDTML IEMAKEKHSA DPMYTLENIA VTVADLLFAG 300
TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPSRIPA IKDRLDMPYL DAVVHEIQRF 360
IDLIPSNLLH EATQDTVFRG YVIPKGTLII PTLDSVLYDR QEFPEPEEFK PEHFLNESGK 420
FKYSDHFKAF SAGKRVCVGE GLARMELFLF LAAILQHFNL KSLVDPKDID LSPIAIGFGK 480
IPPRYKLCLI PRSEV 495

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCYP2E1282213Q2TBV4Bos taurusPredictionMore>>
1:1 orthologCYP2E1415128Q9MZY0Canis lupus familiarisPredictionMore>>
1:1 orthologCYP2E1102182294A0A452DL40Capra hircusPredictionMore>>
1:1 orthologCYP2E11571P05181CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologCyp2e113106Q05421Mus musculusPredictionMore>>
1:1 orthologCYP2E1450857A0A2J8J1H0Pan troglodytesPredictionMore>>
1:1 orthologCYP2E1F1SCT4Sus scrofaPredictionMore>>
1:1 orthologCyp2e125086P05182Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0018601 4-nitrophenol 2-monooxygenase activity
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0005506 iron ion binding
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0018960 4-nitrophenol metabolic process
GO:0017144 drug metabolic process
GO:0046483 heterocycle metabolic process
GO:0002933 lipid hydroxylation
GO:0016098 monoterpenoid metabolic process
GO:0008202 steroid metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0349 Heme
KW-0408 Iron
KW-0479 Metal-binding
KW-0503 Monooxygenase
KW-0560 Oxidoreductase
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008070 Cyt_P450_E_grp-I_CYP2E-like
IPR036396 Cyt_P450_sf

PROSITE

PROSITE ID PROSITE Term
PS00086 CYTOCHROME_P450

Pfam

Pfam ID Pfam Term
PF00067 p450