| Tag | Content |
|---|---|
| Uniprot ID | Q9MZY0; Q9MZY1; |
| Entrez ID | 415128 |
| Genbank protein ID | AAF88145.1; AAF88144.1; |
| Genbank nucleotide ID | NM_001003339.1 |
| Ensembl protein ID | ENSCAFP00030042533; ENSCAFP00040030554; ENSCAFP00000034940; |
| Ensembl nucleotide ID | ENSCAFG00040018971; ENSCAFG00000013311; ENSCAFG00030026254; |
| Gene name | Cytochrome P450 2E1 |
| Gene symbol | CYP2E1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. |
| Sequence | MAALGITVAL LVWMATLMLI SIWKQIYSRW KLPPGPFPLP IIGNILQVDI KNVPKSLAKL 60 AEQYGPVFTL YLGSQRTVVL HGYKAVKEVL LDHKNDLSGR GEVFAFQSHK DRGITFNNGP 120 GWKDTRRLSL STLRDYGMGK RGNEERIQRE IPFLLEALRG TRGQPFDPTF LLGFAPFNVI 180 ADILFHKHFD YSDQTGLRIQ KLFNENFHLL STGWLQLYNI FPSYLHYLPG SHRKVLRNVA 240 ELKDYSLERV KEHQESLDPT CSRDFTDCLL QELQKERYGT EPWYTLDNIA VTVADLFFAG 300 TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPSRVPA IKDRLEMPYM DAVVHEIQRF 360 IDLLPSNLPH VANQDTMFRG YVIPKGTVVI PTLDSVLFDK QEFPDPEKFK PEHFLNENGK 420 FKYSDYFKAF SAGKRVCVGE GLARMELFLF LSAILQHFNL KSLVDPKDID LSPCTIGFAK 480 IPPHYKLCVV PRSG 494 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP2E1 | 282213 | Q2TBV4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 415128 | Q9MZY0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 102182294 | A0A452DL40 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 1571 | P05181 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Cyp2e1 | 13106 | Q05421 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 450857 | A0A2J8J1H0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | F1SCT4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Cyp2e1 | 25086 | P05182 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0005743 | mitochondrial inner membrane |
| GO:0018601 | 4-nitrophenol 2-monooxygenase activity |
| GO:0008392 | arachidonic acid epoxygenase activity |
| GO:0070330 | aromatase activity |
| GO:0019899 | enzyme binding |
| GO:0020037 | heme binding |
| GO:0030544 | Hsp70 protein binding |
| GO:0051879 | Hsp90 protein binding |
| GO:0005506 | iron ion binding |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO:0008395 | steroid hydroxylase activity |
| GO:0018960 | 4-nitrophenol metabolic process |
| GO:0019373 | epoxygenase P450 pathway |
| GO:0042738 | exogenous drug catabolic process |
| GO:0046483 | heterocycle metabolic process |
| GO:0002933 | lipid hydroxylation |
| GO:0016098 | monoterpenoid metabolic process |
| GO:0006082 | organic acid metabolic process |
| GO:0055114 | oxidation-reduction process |
| GO:0009617 | response to bacterium |
| GO:0008202 | steroid metabolic process |
| GO:0006805 | xenobiotic metabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0256 | Endoplasmic reticulum |
| KW-0276 | Fatty acid metabolism |
| KW-0349 | Heme |
| KW-0408 | Iron |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0492 | Microsome |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0503 | Monooxygenase |
| KW-0521 | NADP |
| KW-0560 | Oxidoreductase |
| KW-0621 | Polymorphism |
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |