| Tag | Content |
|---|---|
| Uniprot ID | P05182 |
| Entrez ID | 25086 |
| Genbank protein ID | AAA41060.1; AAB24151.1; AAH81774.1; AAC15991.1; AAA41033.1; |
| Genbank nucleotide ID | NM_031543.1 |
| Ensembl protein ID | ENSRNOP00000016883 |
| Ensembl nucleotide ID | ENSRNOG00000012458 |
| Gene name | Cytochrome P450 2E1 |
| Gene symbol | Cyp2e1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. |
| Sequence | MAVLGITIAL LVWVATLLVI SIWKQIYNSW NLPPGPFPLP ILGNIFQLDL KDIPKSFTKL 60 AKRFGPVFTL HLGSRRIVVL HGYKAVKEVL LNHKNEFSGR GDIPVFQEYK NKGIIFNNGP 120 TWKDVRRFSL SILRDWGMGK QGNEARIQRE AQFLVEELKK TKGQPFDPTF LIGCAPCNVI 180 ADILFNKRFD YNDKKCLRLM SLFNENFYLL STPWIQLYNN FADYLRYLPG SHRKIMKNVS 240 EIKQYTLEKA KEHLQSLDIN CARDVTDCLL IEMEKEKHSQ EPMYTMENVS VTLADLFFAG 300 TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRVPA VRDRLDMPYM DAVVHEIQRF 360 INLVPSNLPH EATRDTVFQG YVIPKGTVVI PTLDSLLYDS HEFPDPEKFK PEHFLNENGK 420 FKYSDYFKAF SAGKRVCVGE GLARMELFLL LSAILQHFNL KSLVDPKDID LSPVTVGFGS 480 IPPQFKLCVI PRS 493 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP2E1 | 282213 | Q2TBV4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 415128 | Q9MZY0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 102182294 | A0A452DL40 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 1571 | P05181 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Cyp2e1 | 13106 | Q05421 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 450857 | A0A2J8J1H0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | F1SCT4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Cyp2e1 | 25086 | P05182 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005783 | endoplasmic reticulum |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0000139 | Golgi membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0031227 | intrinsic component of endoplasmic reticulum membrane |
| GO:0005743 | mitochondrial inner membrane |
| GO:0005739 | mitochondrion |
| GO:0018601 | 4-nitrophenol 2-monooxygenase activity |
| GO:0008392 | arachidonic acid epoxygenase activity |
| GO:0070330 | aromatase activity |
| GO:0019899 | enzyme binding |
| GO:0020037 | heme binding |
| GO:0030544 | Hsp70 protein binding |
| GO:0051879 | Hsp90 protein binding |
| GO:0005506 | iron ion binding |
| GO:0004497 | monooxygenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO:0008395 | steroid hydroxylase activity |
| GO:0018960 | 4-nitrophenol metabolic process |
| GO:0017144 | drug metabolic process |
| GO:0019373 | epoxygenase P450 pathway |
| GO:0042738 | exogenous drug catabolic process |
| GO:0046483 | heterocycle metabolic process |
| GO:0002933 | lipid hydroxylation |
| GO:0016098 | monoterpenoid metabolic process |
| GO:0006082 | organic acid metabolic process |
| GO:0055114 | oxidation-reduction process |
| GO:0009617 | response to bacterium |
| GO:0042493 | response to drug |
| GO:0045471 | response to ethanol |
| GO:0010243 | response to organonitrogen compound |
| GO:0010193 | response to ozone |
| GO:0008202 | steroid metabolic process |
| GO:0006641 | triglyceride metabolic process |
| GO:0006805 | xenobiotic metabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0903 | Direct protein sequencing |
| KW-0256 | Endoplasmic reticulum |
| KW-0276 | Fatty acid metabolism |
| KW-0349 | Heme |
| KW-0408 | Iron |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0492 | Microsome |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0503 | Monooxygenase |
| KW-0521 | NADP |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |