| Tag | Content |
|---|---|
| Uniprot ID | Q05421; Q9Z198; |
| Entrez ID | 13106 |
| Genbank protein ID | CAA44481.1; AAA37275.1; CAA25510.1; AAA39879.1; AAH13451.1; |
| Genbank nucleotide ID | NM_021282.2 |
| Ensembl protein ID | ENSMUSP00000026552 |
| Ensembl nucleotide ID | ENSMUSG00000025479 |
| Gene name | Cytochrome P450 2E1 |
| Gene symbol | Cyp2e1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. |
| Sequence | MAVLGITVAL LVWIATLLLV SIWKQIYRSW NLPPGPFPIP FFGNIFQLDL KDIPKSLTKL 60 AKRFGPVFTL HLGQRRIVVL HGYKAVKEVL LNHKNEFSGR GDIPVFQEYK NKGIIFNNGP 120 TWKDVRRFSL SILRDWGMGK QGNEARIQRE AHFLVEELKK TKGQPFDPTF LIGCAPCNVI 180 ADILFNKRFD YDDKKCLELM SLFNENFYLL STPWIQAYNY FSDYLQYLPG SHRKVMKNVS 240 EIRQYTLGKA KEHLKSLDIN CPRDVTDCLL IEMEKEKHSQ EPMYTMENIS VTLADLFFAG 300 TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRAPA VRDRMNMPYM DAVVHEIQRF 360 INLVPSNLPH EATRDTVFRG YVIPKGTVVI PTLDSLLFDN YEFPDPETFK PEHFLNENGK 420 FKYSDYFKAF SAGKRVCVGE GLARMELFLL LSAILQHFNL KSLVDPKDID LSPVTIGFGS 480 IPREFKLCVI PRS 493 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP2E1 | 282213 | Q2TBV4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 415128 | Q9MZY0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 102182294 | A0A452DL40 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 1571 | P05181 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Cyp2e1 | 13106 | Q05421 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | 450857 | A0A2J8J1H0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CYP2E1 | F1SCT4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Cyp2e1 | 25086 | P05182 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004497 | monooxygenase activity | ISO |
| GO:0004497 | monooxygenase activity | IDA |
| GO:0005506 | iron ion binding | IEA |
| GO:0008392 | arachidonic acid epoxygenase activity | IBA |
| GO:0008395 | steroid hydroxylase activity | IBA |
| GO:0016491 | oxidoreductase activity | ISO |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | ISO |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | IBA |
| GO:0018601 | 4-nitrophenol 2-monooxygenase activity | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0020037 | heme binding | ISS |
| GO:0020037 | heme binding | ISO |
| GO:0020037 | heme binding | IBA |
| GO:0030544 | Hsp70 protein binding | ISS |
| GO:0030544 | Hsp70 protein binding | ISO |
| GO:0051879 | Hsp90 protein binding | ISS |
| GO:0051879 | Hsp90 protein binding | ISO |
| GO:0070330 | aromatase activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002933 | lipid hydroxylation | ISO |
| GO:0006082 | organic acid metabolic process | IBA |
| GO:0006641 | triglyceride metabolic process | ISO |
| GO:0006805 | xenobiotic metabolic process | ISO |
| GO:0006805 | xenobiotic metabolic process | IBA |
| GO:0008202 | steroid metabolic process | ISO |
| GO:0009617 | response to bacterium | IEP |
| GO:0010193 | response to ozone | IEA |
| GO:0010243 | response to organonitrogen compound | IEA |
| GO:0016098 | monoterpenoid metabolic process | ISO |
| GO:0017144 | drug metabolic process | ISO |
| GO:0018960 | 4-nitrophenol metabolic process | ISO |
| GO:0019373 | epoxygenase P450 pathway | IBA |
| GO:0042738 | exogenous drug catabolic process | IBA |
| GO:0045471 | response to ethanol | IEA |
| GO:0046483 | heterocycle metabolic process | ISO |
| GO:0055114 | oxidation-reduction process | ISO |
| GO:0055114 | oxidation-reduction process | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | ISO |
| GO:0005737 | cytoplasm | IBA |
| GO:0005739 | mitochondrion | ISO |
| GO:0005743 | mitochondrial inner membrane | ISS |
| GO:0005743 | mitochondrial inner membrane | ISO |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005789 | endoplasmic reticulum membrane | ISO |
| GO:0031227 | intrinsic component of endoplasmic reticulum membrane | ISO |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0043231 | intracellular membrane-bounded organelle | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-211859 | Biological oxidations | IEA |
| R-MMU-211897 | Cytochrome P450 - arranged by substrate type | IEA |
| R-MMU-211945 | Phase I - Functionalization of compounds | IEA |
| R-MMU-211981 | Xenobiotics | IEA |
| R-MMU-211999 | CYP2E1 reactions | IEA |
| R-MMU-556833 | Metabolism of lipids | IEA |
| R-MMU-9018677 | Biosynthesis of DHA-derived SPMs | IEA |
| R-MMU-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | IEA |
| R-MMU-9018682 | Biosynthesis of maresins | IEA |
| R-MMU-9027307 | Biosynthesis of maresin-like SPMs | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0256 | Endoplasmic reticulum |
| KW-0276 | Fatty acid metabolism |
| KW-0349 | Heme |
| KW-0408 | Iron |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0492 | Microsome |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0503 | Monooxygenase |
| KW-0521 | NADP |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |