| Tag | Content |
|---|---|
| Uniprot ID | A0A452ESG3 |
| Entrez ID | 102175335 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018066182.1; XM_018066181.1; XM_018066183.1; |
| Ensembl protein ID | ENSCHIP00000015119 |
| Ensembl nucleotide ID | ENSCHIG00000015885 |
| Gene name | Uncharacterized protein |
| Gene symbol | DICER1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT 60 IVCLNTGSGK TFIAVLLTKE LSYQIRGDFN RSGRRTVFLV NSANQVAQQV SAVRTHSDLK 120 VGEYSNLEVT ASWTKEKWNQ EFTKHQVLVM TCYVALNVLK NGYLSLSDIN LLVFDECHLA 180 ILDHPYREIM KLCENCPSCP RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL 240 VVLDRYTSQP CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNISVHS KERDSTLISK 300 QILSDCRAVL VVLGPWCADK VAGMMVRELQ KHIKHEQEEL HRKFLLFTDT FLRKIHALCE 360 EHFSPASLDL KFVTPKVIKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDEE 420 DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT 480 GHGIGKNQPR NKQMEAEFRK QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP 540 TEYRSYVQSK GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGEAD 600 TEPVVDDDDV FPPYVLRPED GPRVTINTAI GHVNRYCARL PSDPFTHLAP KCRTRELPDG 660 TFYSTLYLPI NSPLRASIVG PPMSCIRLAE RVVALICCEK LHKIGELDDH LMPVGKETVK 720 YEEELDLHDE EETSVPGRPG STKRRQCYPK AIPECLRESY PKPGQPCYLY VIGMVLTTPL 780 PDELNFRRRK LYPPEDTTRC FGILTAKPIP QIPHFPVYTR SGEVTISIEL KKSGFTLSLQ 840 MLELITRLHQ YIFSHILRLE KPALEFKPAD ADSAYCVLPL NVVNDSSTLD IDFKFMEDIE 900 KSEARIGIPS TKYSKETPFV FKLEDYQDAV IIPRYRNFDQ PHRFYVADVY TDLTPLSKFP 960 SPEYETFAEY YKTKYNLDLT NLNQPLLDVD HTSSRLNLLT PRHLNQKGKA LPLSSAEKRK 1020 AKWESLQNKQ ILVPELCAIH PIPASLWRKA VCLPSILYRL HCLLTAEELR AQTASDAGVG 1080 VRSLPVDFRY PNLDFGWKKS IDSKSFISIA NSSSAENENY CKHSTIVVPE NAAHQGANRT 1140 SSLENHDQMS VNCRTLFSES PGKLQVEVST DLTAINGLSY NKSLANGSYD LANRDFCQGN 1200 HLNYYKQEIP VQPTTSYPIQ NLYNYENQPK PSDECTLLSN KYLDGNANTS TSDGSPVTAA 1260 VPGTTEAGEA PPDRTASEQS PSPGHSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD 1320 SFLKHAITTY LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW 1380 LPPGYVVNQD KSNTEKWEKD EMTKDCMLAN GKLDDDFEEE EEEEEDLMWR APKEDADDED 1440 DFLEYDQEHI KFIDNMLMGS GAFVKKISLS PFSATDSAYE WKMPKKSSLG SLPFSSDFED 1500 FDYSSWDAMC YLDPSKAVEE DDFVVGFWNP SEENCGVDAG KQSISYDLHT EQCIADKSIA 1560 DCVEALLGCY LTSCGERAAQ LFLCSLGLKV LPVIRRTDRE KAMCPARENF TSQQKTLSGS 1620 RAAASGAGYR ASVLKDLEYG CLKIPPRCMF DHPDADRTLR HLISGFENFE KKINYRFKNK 1680 AYLLQAFTHA SYHYNTITDC YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV 1740 NNTIFASLAV KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE 1800 DIEVPKAMGD IFESLAGAIY MDSGMSLETV WQVYYPMMRP LIEKFSANVP RSPVRELLEM 1860 EPETAKFSPA ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA KSAAARRALR SLKANQPQVP 1920 NS 1922 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DICER1 | 480426 | E2RIN4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 102175335 | A0A452ESG3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 23405 | Q9UPY3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Dicer1 | Q8R418 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | DICER1 | 453137 | H2R458 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | A0A287A263 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dicer1 | 299284 | E9PU15 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dicer1 | 324724 | Q6TV19 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0070062 | extracellular exosome |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0016442 | RISC complex |
| GO:0070578 | RISC-loading complex |
| GO:0005524 | ATP binding |
| GO:0003677 | DNA binding |
| GO:0003725 | double-stranded RNA binding |
| GO:0070883 | pre-miRNA binding |
| GO:0019904 | protein domain specific binding |
| GO:0004525 | ribonuclease III activity |
| GO:0035197 | siRNA binding |
| GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference |
| GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0038061 | NIK/NF-kappaB signaling |
| GO:0031054 | pre-miRNA processing |
| GO:0035087 | siRNA loading onto RISC involved in RNA interference |
| GO:0030423 | targeting of mRNA for destruction involved in RNA interference |
| GO:0035148 | tube formation |