| Tag | Content |
|---|---|
| Uniprot ID | H2R458; A0A2J8QME0; |
| Entrez ID | 453137 |
| Genbank protein ID | JAA16072.1; JAA16073.1; JAA42511.1; JAA31717.1; JAA06775.1; JAA31718.1; JAA42512.1; |
| Genbank nucleotide ID | XM_001154369.5; XM_016926683.1; XM_016926681.1; XM_009428378.2; XM_016926682.1; |
| Ensembl protein ID | ENSPTRP00000046628 |
| Ensembl nucleotide ID | ENSPTRG00000023484 |
| Gene name | Dicer 1, ribonuclease III |
| Gene symbol | DICER1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKNPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT 60 IVCLNTGSGK TFIAVLLTKE LSYQIRGDFS RNGKRTVFLV NSANQVAQQV SAVRTHSDLK 120 VGEYSNLEVN ASWTKERWNQ EFTKHQVLIM TCYVALNVLK NGYLSLSDIN LLVFDECHLA 180 ILDHPYREIM KLCENCPSCP RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL 240 VVLDRYTSQP CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNISVHS KERDSTLISK 300 QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT FLRKIHALCE 360 EHFSPASLDL KFVTPKVIKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDE 420 DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT 480 GHGIGKNQPR NKQMEAEFRK QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP 540 TEYRSYVQSK GRARAPISNY IMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGEID 600 IDPVMDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD 660 GTFYSTLYLP INSPLRASIV GPPMSCVRLA ERVVALICCE KLHKIGELDD HLMPVGKETV 720 KYEEELDLHD EEETSVPGRP GSTKRRQCYP KAIPECLRDS YPRPDQPCYL YVIGMVLTTP 780 LPDELNFRRR KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFMLSL 840 QMLELITRLH QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI 900 EKSEARIGIP STKYTKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF 960 PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR 1020 KAKWESLQNK QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV 1080 GVRSLPADFR YPNLDFGWKK SIDSKSFISI SNSSSAENDN YCKHSTIVPE NAAHQGANRT 1140 SSLENHDQMS VNCRTLLSES PGKLHVEVSA DLTAINGLSY NQNLANGSYD LANRDFCQGN 1200 QLNYYKQEIP VQPTTSYSIQ NLYSYENQPQ PSDECTLLSN KYLDGNANKS TSDGSPVMAV 1260 MPGTTDTIQV LKGRMDSEQS PSIGYSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD 1320 SFLKHAITTY LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW 1380 LPPGYVVNQD KSNTDKWEKD EMTKDCMLAN GKLDEDYEEE DEEEESLMWR APKEEADYED 1440 DFLEYDQEHI RFIDNMLMGS GAFVKKISLS PFSTTDSAYE WKMPKKSSLG SMPFSSDFED 1500 FDYSSWDAMC YLDPSKAVEE DDFVVGFWNP SEENCGVDTG KQSISYDLHT EQCIADKSIA 1560 DCVEALLGCY LTSCGERAAQ LFLCSLGLKV LPVIKRTDRE KALCPTRENF NSQQKNLSVS 1620 CAAASVASSR SSVLKDSEYG CLKIPPRCMF DHPDADKTLN HLISGFENFE KKINYRFKNK 1680 AYLLQAFTHA SYHYNTITDC YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV 1740 NNTIFASLAV KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE 1800 DIEVPKAMGD IFESLAGAIY MDSGMSLETV WQVYYPMMRP LIEKFSANVP RSPVRELLEM 1860 EPETAKFSPA ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA KSAAARRALR SLKANQPQVP 1920 NS 1922 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DICER1 | 480426 | E2RIN4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 102175335 | A0A452ESG3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 23405 | Q9UPY3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Dicer1 | Q8R418 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | DICER1 | 453137 | H2R458 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | A0A287A263 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dicer1 | 299284 | E9PU15 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dicer1 | 324724 | Q6TV19 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0070062 | extracellular exosome |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0016442 | RISC complex |
| GO:0070578 | RISC-loading complex |
| GO:0005524 | ATP binding |
| GO:0004530 | deoxyribonuclease I activity |
| GO:0003677 | DNA binding |
| GO:0003725 | double-stranded RNA binding |
| GO:0070883 | pre-miRNA binding |
| GO:0019904 | protein domain specific binding |
| GO:0004525 | ribonuclease III activity |
| GO:0003723 | RNA binding |
| GO:0035197 | siRNA binding |
| GO:0006309 | apoptotic DNA fragmentation |
| GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference |
| GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0038061 | NIK/NF-kappaB signaling |
| GO:0031054 | pre-miRNA processing |
| GO:0030422 | production of siRNA involved in RNA interference |
| GO:0090501 | RNA phosphodiester bond hydrolysis |
| GO:0035087 | siRNA loading onto RISC involved in RNA interference |
| GO:0030423 | targeting of mRNA for destruction involved in RNA interference |
| GO:0035148 | tube formation |