| Tag | Content |
|---|---|
| Uniprot ID | E9PU15 |
| Entrez ID | 299284 |
| Genbank protein ID | EDL81806.1 |
| Genbank nucleotide ID | XM_017603278.1; XM_017603276.1; XM_017603279.1; XM_017594499.1; XM_017594500.1; XM_008764904.2; XM_017594501.1; XM_008776310.2; XM_017594498.1; XM_017594502.1; XM_017603280.1; XM_017603281.1; XM_017594504.1; XM_017603277.1; XM_017594503.1; XM_017603282.1; |
| Ensembl protein ID | ENSRNOP00000014405 |
| Ensembl nucleotide ID | ENSRNOG00000010711 |
| Gene name | Dicer 1 ribonuclease III |
| Gene symbol | Dicer1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT 60 IVCLNTGSGK TFIAVLLTKE LAHQIRGDLS PHAKRTVFLV NSANQVAQQV SAVRTHSDLK 120 VGEYSNLEVN ASWTKERWSQ EFTKHQVLIM TCYVALNVLK NGYLSLSDIN LLVFDECHLA 180 ILDHPYREIM KLCDSCPSCP RILGLTASIL NGKCDPDELE EKIQKLEKIL KSGAETATDL 240 VVLDRYTSQP CEIVVDCGPF TDRSGLYERL LMELEEALDF INDCNVSVHS KERDSTLISK 300 QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT LLRKIHALCE 360 EYFSPASLDL KYVTPKVMKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDD 420 DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT 480 GHGIGKNQPR SKQMEAEFRK QEEVLRKFRA HETNLLIATS VVEEGVDIPK CNLVVRFDLP 540 TEYRSYVQSK GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDGAEAD 600 VHAVVDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD 660 GTFYSTLYLP INSPLRASIV GPPMGCVRLA ERVVALICCE KLHKIGELDE HLMPVGKETV 720 KYEEELDLHD EEETSVPGRP GSTKRRQCYP KAIPECLRES YPKPDQPCYL YVIGMVLTTP 780 LPDELNFRRR KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSQ 840 QMLELVTRLH QYIFSHILRL EKPALEFQPA GAESAYCVLP LNVVNDSSTL DIDFKFMEDI 900 EKSEARIGIP STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF 960 PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR 1020 KAKWESLQNK QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV 1080 GVRSLPADFR YPNLDFGWKK SIDSKSFIST CNSSLAESDN YCKHSTTVVP ENAAHQGATR 1140 PSLENHDQMS VNCKRLPAES PAKLQSEVSV DLTAINGLSY NKSLANGSYD LVNRDFCQGN 1200 QLTYFKQEIP VQPTTSYPIQ NLYNYENQPT PSNECPLLSN KYLDGNANTS TSDGSPAGSP 1260 RPAMMTAVEA LEGRTDSEQS PSVGHSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD 1320 SFLKHAITTY LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKQGLPSRMV VSIFDPPVNW 1380 LPPGYVVNQD KSNSEKWEKD EMTKDCLLAN GKLGEDCEEE EEEELAWRAP KEEAEYEDDL 1440 LEYDQEHIQF IDSMLMGSGA FVKKIPLSPF STSDSAYEWK MPKKASLGSV PFSSDLEDFD 1500 YSSWDAMCYL DPSKAVEEDD FVVGFWNPSE ENCGVDTGKQ SISYDLHTEQ CIADKSIADC 1560 VEALLGCYLT SCGERAAQLF LCSLGLKVLP VIKRTSRDKA SYPAQENSSS QQKSPSGSCA 1620 AAVSPRSSAG KDLEYGCLKI PPRCMFDHPD AEKTLNHLIS GFENFEKKIN YIFKNKAYLL 1680 QAFTHASYHY NTITDCYQRL EFLGDAILDY LITKHLYEDP RQHSPGVLTD LRSALVNNTI 1740 FASLAVKYDY HKYFKAVSPE LFHVIDDFVQ FQLEKNEMQG MDSELRRSEE DEEKEEDIEV 1800 PKAMGDIFES LAGAIYMDSG MSLEVVWQVY YPMMRPLIEK FSANVPRSPV RELLEMEPET 1860 AKFSPAERTY DGKVRVTVEV VGKGKFKGVG RSYRIAKSAA ARRALRSLKA NQPLVPNS 1918 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DICER1 | 480426 | E2RIN4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 102175335 | A0A452ESG3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 23405 | Q9UPY3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Dicer1 | Q8R418 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | DICER1 | 453137 | H2R458 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | A0A287A263 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dicer1 | 299284 | E9PU15 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dicer1 | 324724 | Q6TV19 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030424 | axon |
| GO:0034507 | chromosome, centromeric outer repeat region |
| GO:0005737 | cytoplasm |
| GO:0030425 | dendrite |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0070062 | extracellular exosome |
| GO:0030426 | growth cone |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0016442 | RISC complex |
| GO:0070578 | RISC-loading complex |
| GO:0005524 | ATP binding |
| GO:0004530 | deoxyribonuclease I activity |
| GO:0003677 | DNA binding |
| GO:0003725 | double-stranded RNA binding |
| GO:0004521 | endoribonuclease activity |
| GO:0035198 | miRNA binding |
| GO:0070883 | pre-miRNA binding |
| GO:0019904 | protein domain specific binding |
| GO:0004525 | ribonuclease III activity |
| GO:0003723 | RNA binding |
| GO:0035197 | siRNA binding |
| GO:0048856 | anatomical structure development |
| GO:0001525 | angiogenesis |
| GO:0006309 | apoptotic DNA fragmentation |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0055013 | cardiac muscle cell development |
| GO:0061309 | cardiac neural crest cell development involved in outflow tract morphogenesis |
| GO:0051216 | cartilage development |
| GO:0008283 | cell population proliferation |
| GO:0021987 | cerebral cortex development |
| GO:1990141 | chromatin silencing at centromere outer repeat region |
| GO:0036404 | conversion of ds siRNA to ss siRNA |
| GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference |
| GO:0051607 | defense response to virus |
| GO:0048565 | digestive tract development |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048730 | epidermis morphogenesis |
| GO:0061548 | ganglion development |
| GO:0071335 | hair follicle cell proliferation |
| GO:0001942 | hair follicle development |
| GO:0031069 | hair follicle morphogenesis |
| GO:0060119 | inner ear receptor cell development |
| GO:0060576 | intestinal epithelial cell development |
| GO:0030324 | lung development |
| GO:0000212 | meiotic spindle organization |
| GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA |
| GO:0048255 | mRNA stabilization |
| GO:0035264 | multicellular organism growth |
| GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration |
| GO:0010629 | negative regulation of gene expression |
| GO:0060253 | negative regulation of glial cell proliferation |
| GO:0010626 | negative regulation of Schwann cell proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0021675 | nerve development |
| GO:0048812 | neuron projection morphogenesis |
| GO:0038061 | NIK/NF-kappaB signaling |
| GO:0021889 | olfactory bulb interneuron differentiation |
| GO:0032290 | peripheral nervous system myelin formation |
| GO:0010628 | positive regulation of gene expression |
| GO:2000630 | positive regulation of miRNA metabolic process |
| GO:0031643 | positive regulation of myelination |
| GO:0014040 | positive regulation of Schwann cell differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0009791 | post-embryonic development |
| GO:0031054 | pre-miRNA processing |
| GO:0035196 | production of miRNAs involved in gene silencing by miRNA |
| GO:0030422 | production of siRNA involved in RNA interference |
| GO:0051726 | regulation of cell cycle |
| GO:0045595 | regulation of cell differentiation |
| GO:0070173 | regulation of enamel mineralization |
| GO:0010468 | regulation of gene expression |
| GO:0050727 | regulation of inflammatory response |
| GO:2000628 | regulation of miRNA metabolic process |
| GO:0010660 | regulation of muscle cell apoptotic process |
| GO:0031641 | regulation of myelination |
| GO:0050767 | regulation of neurogenesis |
| GO:0045664 | regulation of neuron differentiation |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth |
| GO:0048713 | regulation of oligodendrocyte differentiation |
| GO:0001932 | regulation of protein phosphorylation |
| GO:0045589 | regulation of regulatory T cell differentiation |
| GO:0051252 | regulation of RNA metabolic process |
| GO:2000736 | regulation of stem cell differentiation |
| GO:0045069 | regulation of viral genome replication |
| GO:0048608 | reproductive structure development |
| GO:0016246 | RNA interference |
| GO:0090501 | RNA phosphodiester bond hydrolysis |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
| GO:0006396 | RNA processing |
| GO:0035087 | siRNA loading onto RISC involved in RNA interference |
| GO:0007284 | spermatogonial cell division |
| GO:0021522 | spinal cord motor neuron differentiation |
| GO:0051225 | spindle assembly |
| GO:0048536 | spleen development |
| GO:0019827 | stem cell population maintenance |
| GO:0030423 | targeting of mRNA for destruction involved in RNA interference |
| GO:0001834 | trophectodermal cell proliferation |
| GO:0035148 | tube formation |
| GO:0010070 | zygote asymmetric cell division |