| Tag | Content |
|---|---|
| Uniprot ID | E2RIN4 |
| Entrez ID | 480426 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_863433.4; XM_014116140.1; |
| Ensembl protein ID | ENSCAFP00000026123 |
| Ensembl nucleotide ID | ENSCAFG00000017701 |
| Gene name | Dicer 1, ribonuclease III |
| Gene symbol | DICER1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT 60 IVCLNTGSGK TFIAVLLTKE LSYQIRGDFN RNGKRTVFLV NSANQVAQQV SAVRTHSDLK 120 VGEYSNLEVN ASWTKEKWNQ EFTKHQVLVM TCYVALNVLK NGYLSLSDIN LLVFDECHLA 180 ILDHPYREIM KLCENCPSCP RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL 240 VVLDRYTSQP CEIVVDCGPF TDRSGLYGRL LVELEEALNF INDCNISVHS KERDSTLISK 300 QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT FLRKIHALCE 360 EHFSPASLDL KFVTPKVIKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDE 420 DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT 480 GHGIGKNQPR NKQMEAEFRK QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP 540 TEYRSYVQSK GRARAPISNY IMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGETD 600 IEPVVDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD 660 GTFYSTLYLP INSPLRASIV GPPMSCVRLA ERVVALICCE KLHKIGELDD HLMPVGKETV 720 KYEEELDLHD EEETSVPGRP GSTKRRQCYP KAIPECLRDS YPKPDQPCYL YVIGMVLTTP 780 LPDELNFRRR KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSL 840 QMLELITRLH QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI 900 EKSEARIGIP STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF 960 PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR 1020 KAKWESLQNK QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV 1080 GVRSLPVDFR YPNLDFGWKK SIDSKSFISV ANSSSAENEN YCKHSTIVVP ENAARQGANR 1140 TSSLENHDQM SVNCRTLFSE SPGKLQIEVV TDLTAINGLS YNKNLANGSY DLANRDFCQG 1200 NQLNYYKQEI PVQPTTSYPI QNLYNYENQP KPSDECTLLS NKYLDGNANK STSDGSPTTA 1260 AMPGTTEAVR ALKDKMGSEQ SPCPGYSSRT LGPNPGLILQ ALTLSNASDG FNLERLEMLG 1320 DSFLKHAITT YLFCTYPDAH EGRLSYMRSK KVSNCNLYRL GKKKGLPSRM VVSIFDPPVN 1380 WLPPGYVVNQ DKSNADKWEK DEMTKDCMLA NGKLDEDFEE DDEEEEDLMW RAPKEDADYE 1440 DDFLEYDQEH IKFIDNMLMG SGAFVKKISL SPFSTTDSAY EWKMPKKSSL GSMPFSSDFE 1500 DFDYSSWDAM CYLDPSKAVE EDDFVVGFWN PSEENCGVDT GKQSISYDLH TEQCIADKSI 1560 ADCVEALLGC YLTSCGERAA QLFLCSLGLK VLPVMKRTDR EKTMCPPREN FSSQQKNLSG 1620 GRAAASVASL RPSVLKDLEY GCLKIPPRCM FDHPDADKTL NHLISGFENF EKKINYRFKN 1680 KAYLLQAFTH ASYHYNTITD CYQRLEFLGD AILDYLITKH LYEDPRQHSP GVLTDLRSAL 1740 VNNTIFASLA VKYDYHKYFK AVSPELFHVI DDFVQFQLEK NEMQGMDSEL RRSEEDEEKE 1800 EDIEVPKAMG DIFESLAGAI YMDSGMSLEM VWQVYYPMMR PLIEKFSANV PRSPVRELLE 1860 MEPETAKFSP AERTYDGKVR VTVEVVGKGK FKGVGRSYRI AKSAAARRAL RSLKANQPQV 1920 PNS 1923 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DICER1 | 480426 | E2RIN4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 102175335 | A0A452ESG3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 23405 | Q9UPY3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Dicer1 | Q8R418 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | DICER1 | 453137 | H2R458 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | A0A287A263 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dicer1 | 299284 | E9PU15 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dicer1 | 324724 | Q6TV19 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0070062 | extracellular exosome |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0016442 | RISC complex |
| GO:0070578 | RISC-loading complex |
| GO:0005524 | ATP binding |
| GO:0004530 | deoxyribonuclease I activity |
| GO:0003725 | double-stranded RNA binding |
| GO:0070883 | pre-miRNA binding |
| GO:0019904 | protein domain specific binding |
| GO:0004525 | ribonuclease III activity |
| GO:0003723 | RNA binding |
| GO:0035197 | siRNA binding |
| GO:0006309 | apoptotic DNA fragmentation |
| GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference |
| GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0038061 | NIK/NF-kappaB signaling |
| GO:0031054 | pre-miRNA processing |
| GO:0030422 | production of siRNA involved in RNA interference |
| GO:0090501 | RNA phosphodiester bond hydrolysis |
| GO:0035087 | siRNA loading onto RISC involved in RNA interference |
| GO:0030423 | targeting of mRNA for destruction involved in RNA interference |
| GO:0035148 | tube formation |