| Tag | Content |
|---|---|
| Uniprot ID | Q6TV19 |
| Entrez ID | 324724 |
| Genbank protein ID | AAQ90464.1 |
| Genbank nucleotide ID | NM_001161453.2; XM_005158665.3; XM_005158666.3; |
| Ensembl protein ID | ENSDARP00000045880 |
| Ensembl nucleotide ID | ENSDARG00000001129 |
| Gene name | Endoribonuclease Dicer |
| Gene symbol | dicer1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). |
| Sequence | MAGLQLVTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALEHNT IVCLNTGSGK 60 TFIAVLLIKE LSHQIRGENG KRTVFLVNAA SSVAQQASTV RTHSDLQVGD YMSEDMTSWP 120 EEMWNREMIE NQVLVMTCHI FLHVLKNGVL PLSKINLLVF DECHLAITGH PYREIMKICE 180 GCPSCPRILG LTASILNGKC DPCDLEEKIQ NLEKILQSNA ETATDLVVLD RYASQPREEV 240 LDCGQYQDQS GLSERLLNEL DEALNFLNDC NLSVHREDRD PTFISKQVLN DCRAVLTVLG 300 PWCADKAAGI MVRELQKYIK HEQEELNRKF LLFTDTILRK IHALCEEHFS PASLDLKFVT 360 PKVIRLLEIL HEYKPFERQQ FESVEWYNNR NQDNYVSWSD SEDDDEDEEA EAKEKTEANF 420 PSPFTNILCG IIFVERRYTA VVLNRLIKEA GKQDPELAYI SSNFITGHSI GKNQPRNKQM 480 EVEFRKQEEV LRKFRAHETN LLIATSIVEE GVDIPKCNLV VRFDLPTEYR SYVQSKGRAR 540 APVSNYIMLA DSERTKTFQE DLKTYKAIEK ILRNKCSKSA ECNDFELEPV TDDDNVLPPY 600 VLRSEDGGPR VTMNTAIGHV NRYCARLPSD PFTHLAPKCK TVEMNTGGYR STLFLPINSP 660 LRVPVTGPVM NCARLAEKAV ALLCCEKLHK IGELDDHLMP VGKETVKYEE ELDLHDEEET 720 SVPGRPGSTK RRQCSPKAIP ECLRGCYPVP EQPCYLYVIG MVLTTPLPDE LNFRRRKLYP 780 PEDTTRCFGI LTAKPIPRIP HFPVYTRSGE VTISIELQKS GFSLSAEQLE LITRLHQYIF 840 SHILRLEKPA LEFKPVEADS AYCVLPLNIV EDSNTLDLDF KFMEDIEKSE ARIGIPNTQY 900 TKQNPFIFKL EDYQDAVIIP RYRNFDQPHR FYVADVYTDL TPLSKFPSPE YETFAEYYKT 960 KYNLDLSNVN QPLLDVDHTS SRLNLLTPRH LNQKGKALPL SSAEKRKAKW ESLQNKQILV 1020 PELCAIHPIP ASLWRKAVCL PSILYRLHCL LTAEELRSQT AIDAGVGAQT LPPDFRYPNL 1080 DFGWKKSIDS KSFISCPSAC MEEDDDHCKL GTSSDSNHTA PESCSMEVSQ PPEGAPNTPD 1140 EKLETLTLPV TDLNKDCFPN LPNGTQADSD DLPHRSDVCQ CSQLGPLERD LSTQTTTSVS 1200 VRPSPAGEPQ PWPSDECTGR SSDLCDPHVK KPTSKHCPKS ETATSTPAPS ETSSEDCRSA 1260 CAGPAWDSPK TLGPNPGLIL QALTLSNASD GFNLERLEML GDSFLKHAIT TYLFCTYPDA 1320 HEGRLSYMRS KKVSNCNLYR LGKKKGLPSR MVVSIFDPPV NWLPPGYVVN QDKSSTDKWD 1380 SDENKDLANG KASDDEDEDD DDEPEEAEVE PSKEDVNVED DLEYYYEHIR FIDSMLIGSG 1440 AFGKKISLQP TDPGYEWKAP KKAHNSHFSP DGGADEFDYS SWDAMCYLDP SKAGEEDDFV 1500 VGFWNPSEEN CGTDIGKQSI SYDLHTEQCI ADKSIADCVE ALLGCYLTSC GERAAQLFLC 1560 SLGLKVLPPE KQSSGGSAEL QYGWLKIPPR CMFEHPDAER TLNHLISGFL NFESKINYTF 1620 KNKAYLLQAF THASYHYNTI TDCYQRLEFL GDAILDYLIT KHLYEDPRQH SPGVLTDLRS 1680 ALVNNTIFAS LAVKYDYHKY FKAVSPELFH VIDDFVQFQL EKNEMQGMDS ELRRSEEDEE 1740 KEEDIEVPKA MGDIFESLAG AIYMDSGMSL ETVWQVYYPM MRPLIEKFSA NVPRSPVREL 1800 LEMEPETAKF SPAERTYDGK VRVTVEVVGK GKFKGVGRSY RIAKSAAARR ALRSLKANQP 1860 QVQNN 1865 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DICER1 | 480426 | E2RIN4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 102175335 | A0A452ESG3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 23405 | Q9UPY3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Dicer1 | Q8R418 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | DICER1 | 453137 | H2R458 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | A0A287A263 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dicer1 | 299284 | E9PU15 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dicer1 | 324724 | Q6TV19 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0016442 | RISC complex |
| GO:0070578 | RISC-loading complex |
| GO:0005524 | ATP binding |
| GO:0004530 | deoxyribonuclease I activity |
| GO:0004386 | helicase activity |
| GO:0046872 | metal ion binding |
| GO:0070883 | pre-miRNA binding |
| GO:0004525 | ribonuclease III activity |
| GO:0003723 | RNA binding |
| GO:0006309 | apoptotic DNA fragmentation |
| GO:1904888 | cranial skeletal system development |
| GO:0035195 | gene silencing by miRNA |
| GO:0031507 | heterochromatin assembly |
| GO:0030318 | melanocyte differentiation |
| GO:0035279 | mRNA cleavage involved in gene silencing by miRNA |
| GO:0014032 | neural crest cell development |
| GO:0031054 | pre-miRNA processing |
| GO:0035196 | production of miRNAs involved in gene silencing by miRNA |
| GO:0030422 | production of siRNA involved in RNA interference |
| GO:0050767 | regulation of neurogenesis |
| GO:0090501 | RNA phosphodiester bond hydrolysis |
| GO:0030423 | targeting of mRNA for destruction involved in RNA interference |
| GO:0021591 | ventricular system development |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-0963 | Cytoplasm |
| KW-0255 | Endonuclease |
| KW-0347 | Helicase |
| KW-0378 | Hydrolase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0479 | Metal-binding |
| KW-0540 | Nuclease |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0694 | RNA-binding |
| KW-0943 | RNA-mediated gene silencing |
| InterPro ID | InterPro Term |
|---|---|
| IPR011545 | DEAD/DEAH_box_helicase_dom |
| IPR038248 | Dicer_dimer_sf |
| IPR005034 | Dicer_dimerisation_dom |
| IPR044441 | DICER_DSRM |
| IPR014720 | dsRBD_dom |
| IPR014001 | Helicase_ATP-bd |
| IPR001650 | Helicase_C |
| IPR027417 | P-loop_NTPase |
| IPR003100 | PAZ_dom |
| IPR036085 | PAZ_dom_sf |
| IPR000999 | RNase_III_dom |
| IPR036389 | RNase_III_sf |