Gene: FZD6

Basic information

Tag Content
Uniprot ID A0A452EZH8
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000017358
Ensembl nucleotide ID ENSCHIG00000017240
Gene name Uncharacterized protein
Gene symbol FZD6
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
METFTFLWTC IFLPLVRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEI 60
FLPLANLECS PNVETFLCKA FVPTCTEQIH VVPPCRKFCE KVYSDCKKLM DTFGIRWPEE 120
LECDRLQYCD ESVPATFNPH TELLDPQKKS EQIRRDIGFW CPRHLKTSGG QGYKFLGIDQ 180
CAPPCPNMYF KSDELEFAKS FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 240
YSIVSLMYFI GFLLGNSTAC NKADEKLELG DTVVLGSQNK ACTILFMFLY FFTMAGTVWW 300
VMLTITWFLA AGRKWSCEAI EQKAVWFHAV AWGIPGFLTI MLLAMNKVEG DNISGVCFVG 360
LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420
SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQANTETR PELALFMIKY 480
LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKKDPISESR RVLQESCEFF LKHNSKVKHK 540
KKHYKPSSHK LKVISKSMGT STGVTANHGT SAVAITNHDY LGQETLTEIQ TSPETSVREV 600
RGDGASTPKL RERNYEEPAS PAAPSSKPSG EQTDRKGQGR SSVSESARSE GRVTPKSDVP 660
GSGPVQSNSV QASSSPEPGS LKGSTSLLVH SASGAGKEQG AGGHSDT 707

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFZD6403610F1P9V1Canis lupus familiarisPredictionMore>>
1:1 orthologFZD6A0A452EZH8Capra hircusPredictionMore>>
1:1 orthologFZD68323O60353CL/PHomo sapiensPublicationMore>>
1:1 orthologFzd614368Q61089E14.5Mus musculusPredictionMore>>
1:1 orthologFZD6464327H2R2C6Pan troglodytesPredictionMore>>
1:1 orthologFZD6F1S0R5Sus scrofaPredictionMore>>
1:1 orthologFZD6100344394G1SWP7Oryctolagus cuniculusPredictionMore>>
1:1 orthologFzd6282581G3V6L1Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0042813 Wnt-activated receptor activity
GO:0007275 multicellular organism development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR041770 FZ6_CRD
IPR026543 FZD6
IPR017981 GPCR_2-like

PROSITE

PROSITE ID PROSITE Term
PS50038 FZ
PS50261 G_PROTEIN_RECEP_F2_4

Pfam

Pfam ID Pfam Term
PF01534 Frizzled
PF01392 Fz