| Tag | Content |
|---|---|
| Uniprot ID | F1P9V1 |
| Entrez ID | 403610 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005627801.2; XM_005627802.2; XM_005627800.2; |
| Ensembl protein ID | ENSCAFP00000000924 |
| Ensembl nucleotide ID | ENSCAFG00000000654 |
| Gene name | Frizzled-6 |
| Gene symbol | FZD6 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEMFTFLWTC VFLPFVRGHS LFTCEPITVP RCMKMAYNMT FFPNLMRHYD QSTAAVKMEP 60 FLPLANLECS PNIETFLCKA FVPACTDQIN VVPPCRKFCE KVYSDCKKLI DTFGMRWPEE 120 LECDRLQYCD ETVPVTFDPH TQFLGPQKNT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 180 CAPPCPNMYF KSDELEFAKS FIGIVSIFCL CATLFTFLTF LIDVKRFRYP ERPIIYYSVC 240 YSIVSLMYFI GFLLGDRTAC NKADEKLELG DTVVLGSQNK ACTVLFMFLY FFTMAGTVWW 300 VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGIPGFLTV MLLAMNKVEG DNISGVCFVG 360 LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420 SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKTETR PELALFMIKY 480 LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 540 KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITNHDY LGQETLTEIQ TSPETSVREV 600 RADGASTPRS REQDCGEPAS PAASSSRLCE EQADRKGRAG NGTDKISISE STRSEGRVTP 660 KSDVTETGPM QSSSLQVPGS SEPGSLKGST SLLVHSASGG RKEHGTGSHS DT 712 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD6 | 403610 | F1P9V1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | A0A452EZH8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 8323 | O60353 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fzd6 | 14368 | Q61089 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FZD6 | 464327 | H2R2C6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | F1S0R5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 100344394 | G1SWP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fzd6 | 282581 | G3V6L1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0045177 | apical part of cell |
| GO:0016327 | apicolateral plasma membrane |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0033278 | cell proliferation in midbrain |
| GO:0035880 | embryonic nail plate morphogenesis |
| GO:0048105 | establishment of body hair planar orientation |
| GO:0001942 | hair follicle development |
| GO:0042472 | inner ear morphogenesis |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0001843 | neural tube closure |
| GO:0030168 | platelet activation |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |