| Tag | Content |
|---|---|
| Uniprot ID | Q61089 |
| Entrez ID | 14368 |
| Genbank protein ID | AAC52431.1 |
| Genbank nucleotide ID | XM_017316430.1; NM_008056.3; NM_001162494.1; |
| Ensembl protein ID | ENSMUSP00000022906; ENSMUSP00000144310; ENSMUSP00000144351; ENSMUSP00000136328; |
| Ensembl nucleotide ID | ENSMUSG00000022297; ENSMUSG00000107137; |
| Gene name | Frizzled-6 |
| Gene symbol | Fzd6 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | E14.5 |
| Data sources | Homology search |
| Reference | |
| Functional description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity). Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. |
| Sequence | MERSPFLLAC ILLPLVRGHS LFTCEPITVP RCMKMTYNMT FFPNLMGHYD QGIAAVEMGH 60 FLHLANLECS PNIEMFLCQA FIPTCTEQIH VVLPCRKLCE KIVSDCKKLM DTFGIRWPEE 120 LECNRLPHCD DTVPVTSHPH TELSGPQKKS DQVPRDIGFW CPKHLRTSGD QGYRFLGIEQ 180 CAPPCPNMYF KSDELDFAKS FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 240 YSIVSLMYFV GFLLGNSTAC NKADEKLELG DTVVLGSKNK ACSVVFMFLY FFTMAGTVWW 300 VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGAPGFLTV MLLAMNKVEG DNISGVCFVG 360 LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420 SGLYLVPLVT LLGCYVYELV NRITWEMTWF SDHCHQYRIP CPYQANPKAR PELALFMIKY 480 LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 540 KKHGAPGPHR LKVISKSMGT STGATTNHGT SAMAIADHDY LGQETSTEVH TSPEASVKEG 600 RADRANTPSA KDRDCGESAG PSSKLSGNRN GRESRAGGLK ERSNGSEGAP SEGRVSPKSS 660 VPETGLIDCS TSQAASSPEP TSLKGSTSLP VHSASRARKE QGAGSHSDA 709 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD6 | 403610 | F1P9V1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | A0A452EZH8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 8323 | O60353 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fzd6 | 14368 | Q61089 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FZD6 | 464327 | H2R2C6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | F1S0R5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 100344394 | G1SWP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fzd6 | 282581 | G3V6L1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0017147 | Wnt-protein binding | IPI |
| GO:0017147 | Wnt-protein binding | IBA |
| GO:0031625 | ubiquitin protein ligase binding | ISO |
| GO:0042813 | Wnt-activated receptor activity | ISO |
| GO:0042813 | Wnt-activated receptor activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001736 | establishment of planar polarity | IGI |
| GO:0001843 | neural tube closure | IGI |
| GO:0001942 | hair follicle development | IMP |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA |
| GO:0030168 | platelet activation | IMP |
| GO:0030901 | midbrain development | IGI |
| GO:0033278 | cell proliferation in midbrain | IGI |
| GO:0035567 | non-canonical Wnt signaling pathway | ISO |
| GO:0035880 | embryonic nail plate morphogenesis | IMP |
| GO:0042472 | inner ear morphogenesis | IGI |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | ISO |
| GO:0048105 | establishment of body hair planar orientation | IGI |
| GO:0060070 | canonical Wnt signaling pathway | IBA |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IDA |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005789 | endoplasmic reticulum membrane | IDA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | TAS |
| GO:0009986 | cell surface | IEA |
| GO:0016021 | integral component of membrane | IBA |
| GO:0016324 | apical plasma membrane | IEA |
| GO:0016327 | apicolateral plasma membrane | IDA |
| GO:0030659 | cytoplasmic vesicle membrane | IEA |
| GO:0045177 | apical part of cell | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-3858494 | Beta-catenin independent WNT signaling | IEA |
| R-MMU-4086398 | Ca2+ pathway | IEA |
| R-MMU-4086400 | PCP/CE pathway | IEA |
| R-MMU-4641263 | Regulation of FZD by ubiquitination | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0256 | Endoplasmic reticulum |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0524 | Neurogenesis |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0832 | Ubl conjugation |
| KW-0879 | Wnt signaling pathway |