| Tag | Content |
|---|---|
| Uniprot ID | H2R2C6 |
| Entrez ID | 464327 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_001156783.4 |
| Ensembl protein ID | ENSPTRP00000043752 |
| Ensembl nucleotide ID | ENSPTRG00000020490 |
| Gene name | Frizzled class receptor 6 |
| Gene symbol | FZD6 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEMFTFLLTC IFLPLVRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH 60 FLPLANLECS PNIETFLCKA FVPTCTEQIH VVPPCRKLCE KVYSDCKKLI DTFGIRWPEE 120 LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 180 CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 240 YSIVSLMYFI GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW 300 VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG DNISGVCFVG 360 LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420 SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKAKAR PELALFMIKY 480 LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 540 KKHYKPSSHK LKVISKSMGT STRSYSNTCT SAVAITSHDY LGQETLTEIQ TSPETSMREV 600 KADGASTPRL REQDCGEPAS PAASISRLSG EQVDRKGQAG SVSENVRSEG RISPKSDITD 660 TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG GCHSDT 706 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD6 | 403610 | F1P9V1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | A0A452EZH8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 8323 | O60353 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fzd6 | 14368 | Q61089 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FZD6 | 464327 | H2R2C6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | F1S0R5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 100344394 | G1SWP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fzd6 | 282581 | G3V6L1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0045177 | apical part of cell |
| GO:0016327 | apicolateral plasma membrane |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0033278 | cell proliferation in midbrain |
| GO:0035880 | embryonic nail plate morphogenesis |
| GO:0048105 | establishment of body hair planar orientation |
| GO:0001942 | hair follicle development |
| GO:0042472 | inner ear morphogenesis |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0001843 | neural tube closure |
| GO:0030168 | platelet activation |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |