| Tag | Content |
|---|---|
| Uniprot ID | G3V6L1 |
| Entrez ID | 282581 |
| Genbank protein ID | EDM16356.1 |
| Genbank nucleotide ID | NM_001130536.1; XM_017594684.1; XM_017594685.1; XM_017594686.1; |
| Ensembl protein ID | ENSRNOP00000006195 |
| Ensembl nucleotide ID | ENSRNOG00000004660 |
| Gene name | Frizzled class receptor 6 |
| Gene symbol | Fzd6 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEASPFLSAC ILLPLIRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QGIAAVEMEH 60 FLPLANLECS PNIEMFLCQA FVPTCTEQID VVSPCRKLCE KILSDCQKLM DTFGIRWPEE 120 LECHRLPYCD GAVPVTSDPH TELFGPQKKT DQVPRDIGFW CPKHLRTSGD QGYRFLGIDQ 180 CAPPCPNMYF KSDELDFAKS FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 240 YSIVSLMYFV GFLLGNSTAC NKADEKLELG NTVVLGSKNK ACSVVFMFLY FFTMAGTVWW 300 VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGMPGFLTV MLLAMNKVEG DNISGVCFVG 360 LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420 SGLYLVPLVT LLGCYVYELV NRVTWEMTWF SDHCHQYRIP CPYQANPKAR PELALFMIKY 480 LMTLIVGISA VFWVGSKKTC TEWAGFCKRN RKRDPISESR RVLQESCEFF LKHNSKVRHK 540 KKHGKPGSHK LKVISKSMGT STGVTTDHGT SAVAIADHDY LGQETSAEVQ TSPEASLKEG 600 RADRANTPRA KGPDCGEPAS TAASNSKFSG DQIDRKSRAG SVKEKSSVSE GAPSEGRVSP 660 KGVPGTGLME CTLQIPSSPE PNSLKGSTSL LVRSASGTRK EQGAGGHSDT |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD6 | 403610 | F1P9V1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | A0A452EZH8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 8323 | O60353 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Fzd6 | 14368 | Q61089 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FZD6 | 464327 | H2R2C6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FZD6 | F1S0R5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FZD6 | 100344394 | G1SWP7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fzd6 | 282581 | G3V6L1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0045177 | apical part of cell |
| GO:0016327 | apicolateral plasma membrane |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0017147 | Wnt-protein binding |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0033278 | cell proliferation in midbrain |
| GO:0035880 | embryonic nail plate morphogenesis |
| GO:0048105 | establishment of body hair planar orientation |
| GO:0001736 | establishment of planar polarity |
| GO:0001942 | hair follicle development |
| GO:0042472 | inner ear morphogenesis |
| GO:0030901 | midbrain development |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0001843 | neural tube closure |
| GO:0035567 | non-canonical Wnt signaling pathway |
| GO:0030168 | platelet activation |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |