Gene: FZD6

Basic information

Tag Content
Uniprot ID G1SWP7
Entrez ID 100344394
Genbank protein ID
Genbank nucleotide ID XM_002710725.3; XM_017341467.1;
Ensembl protein ID ENSOCUP00000007920
Ensembl nucleotide ID ENSOCUG00000009180
Gene name Frizzled class receptor 6
Gene symbol FZD6
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDMFAFLLTC MFLPLIRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QGIAAVEMEH 60
FLPLANLECS PNVETFLCKA FIPTCTEQIH VIPPCRKFCE KVYSDCRKLI DTFGIRWPEE 120
LECNRLQYCD ETAPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 180
CAPPCPNMYF KSDELEFAKS FIGIVSIFCL CATLFTFLTF LIDVKRFRYP ERPIIYYSVC 240
YSIVSLIYFI GFLLGNNTAC NKADEKLELG DTVVLGSQNK ACTVLFMFLY FFTMAGTVWW 300
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGIPGFLTV MLLAMNKVEG DNISGVCFVG 360
LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 420
SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKTKAR PELALFMIKY 480
LMTLIVGISP VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 540
KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITDHDF LGQETLTEIQ TSPEASVREV 600
RADGASTPKV REQDCGEPAS PTAASAKVSG EQADKKSRAG SVKAKNSVSE GVRSEGRVSP 660
KSDDTDTGPV QSNNVQLASS SEPGSLKGST SLLVHSVPGV RKEQGAGSHS DT 712

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFZD6403610F1P9V1Canis lupus familiarisPredictionMore>>
1:1 orthologFZD6A0A452EZH8Capra hircusPredictionMore>>
1:1 orthologFZD68323O60353CL/PHomo sapiensPublicationMore>>
1:1 orthologFzd614368Q61089E14.5Mus musculusPredictionMore>>
1:1 orthologFZD6464327H2R2C6Pan troglodytesPredictionMore>>
1:1 orthologFZD6F1S0R5Sus scrofaPredictionMore>>
1:1 orthologFZD6100344394G1SWP7Oryctolagus cuniculusPredictionMore>>
1:1 orthologFzd6282581G3V6L1Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0045177 apical part of cell
GO:0016327 apicolateral plasma membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031625 ubiquitin protein ligase binding
GO:0042813 Wnt-activated receptor activity
GO:0017147 Wnt-protein binding
GO:0033278 cell proliferation in midbrain
GO:0035880 embryonic nail plate morphogenesis
GO:0048105 establishment of body hair planar orientation
GO:0001942 hair follicle development
GO:0042472 inner ear morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0001843 neural tube closure
GO:0030168 platelet activation
GO:0060071 Wnt signaling pathway, planar cell polarity pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR041770 FZ6_CRD
IPR026543 FZD6
IPR017981 GPCR_2-like

PROSITE

PROSITE ID PROSITE Term
PS50038 FZ
PS50261 G_PROTEIN_RECEP_F2_4

Pfam

Pfam ID Pfam Term
PF01534 Frizzled
PF01392 Fz