| Tag | Content |
|---|---|
| Uniprot ID | E7FB33 |
| Entrez ID | 560564 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_683962.7 |
| Ensembl protein ID | ENSDARP00000069196 |
| Ensembl nucleotide ID | ENSDARG00000077588 |
| Gene name | Platelet-derived growth factor C |
| Gene symbol | pdgfc |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MIPLLLLIVI SSLHQHESVA ESSHISKIHH ASTKEQNGVH ESQHEKVLSV TGDGIIQSPN 60 FPNKYPRNTV IVWQLVAVME SSRIQLTFDP RFGLEDAEEG TCKYDYVEVE EPVGGMVLGR 120 WCGSEMVPGP QLSKGNQILV RFVSDEYFPS DPGFSIRYSL LQQRQSEPEA PAVMPVWMQP 180 VEDLTEAVSA FNTMEEVMKY LEPERWQLDM DDLYKPTWQV LGKSFFHQKK SRGAVDLNLL 240 REDVRLYSCT PRNFSVSLRE ELKRTDAIFW PSCLLVKRCG GNCACCSYNC YDCQCSPTKV 300 AKKYHEVLML KHRTGGRGLQ KTLADVPLEH HEECNCVCKN DSD 343 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFC | 102168934 | A0A452ET29 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFC | 100062015 | A0A3Q2HV05 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFC | 56034 | Q9NRA1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Pdgfc | 54635 | Q8CI19 | CPO | E12.5, E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFC | H2QQC3 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A481CL63 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | PDGFC | 100350272 | G1TDA1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Pdgfc | 79429 | Q9EQX6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pdgfc | 560564 | E7FB33 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0008083 | growth factor activity |
| GO:0070851 | growth factor receptor binding |
| GO:0005161 | platelet-derived growth factor receptor binding |
| GO:0048568 | embryonic organ development |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0051781 | positive regulation of cell division |
| GO:0030335 | positive regulation of cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| GO:0031954 | positive regulation of protein autophosphorylation |