CleftGeneDB-Search

Gene: pdgfc

Basic information

Tag	Content
Uniprot ID	E7FB33
Entrez ID	560564
Genbank protein ID
Genbank nucleotide ID	XM_683962.7
Ensembl protein ID	ENSDARP00000069196
Ensembl nucleotide ID	ENSDARG00000077588
Gene name	Platelet-derived growth factor C
Gene symbol	pdgfc
Organism	Danio rerio
NCBI taxa ID	7955
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description
Sequence	MIPLLLLIVI SSLHQHESVA ESSHISKIHH ASTKEQNGVH ESQHEKVLSV TGDGIIQSPN 60 FPNKYPRNTV IVWQLVAVME SSRIQLTFDP RFGLEDAEEG TCKYDYVEVE EPVGGMVLGR 120 WCGSEMVPGP QLSKGNQILV RFVSDEYFPS DPGFSIRYSL LQQRQSEPEA PAVMPVWMQP 180 VEDLTEAVSA FNTMEEVMKY LEPERWQLDM DDLYKPTWQV LGKSFFHQKK SRGAVDLNLL 240 REDVRLYSCT PRNFSVSLRE ELKRTDAIFW PSCLLVKRCG GNCACCSYNC YDCQCSPTKV 300 AKKYHEVLML KHRTGGRGLQ KTLADVPLEH HEECNCVCKN DSD 343

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

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Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	PDGFC	56034	Q9NRA1			Homo sapiens	Publication	More>>
1:1 ortholog	Pdgfc	54635	Q8CI19	CPO	E12.5, E13.5	Mus musculus	Publication	More>>
1:1 ortholog			A0A481CL63			Sus scrofa	Prediction	More>>
1:1 ortholog	PDGFC	102168934	A0A452ET29			Capra hircus	Prediction	More>>
1:1 ortholog	PDGFC	100062015	A0A3Q2HV05			Equus caballus	Prediction	More>>
1:1 ortholog	PDGFC		H2QQC3			Pan troglodytes	Prediction	More>>
1:1 ortholog	PDGFC	100350272	G1TDA1			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Pdgfc	79429	Q9EQX6			Rattus norvegicus	Prediction	More>>
1:1 ortholog	pdgfc	560564	E7FB33			Danio rerio	Prediction	More>>

Showing 1 to 9 of 9 entries

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Gene ontology

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GO ID	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005615	extracellular space
GO:0008083	growth factor activity
GO:0008284	positive regulation of cell population proliferation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020	membrane
GO:0030335	positive regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0043406	positive regulation of MAP kinase activity
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048568	embryonic organ development
GO:0051781	positive regulation of cell division
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070851	growth factor receptor binding

Showing 1 to 14 of 14 entries

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Functional annotations

Keywords

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Keyword ID	Keyword Term
KW-0165	Cleavage on pair of basic residues
KW-0217	Developmental protein
KW-0325	Glycoprotein
KW-0339	Growth factor
KW-0497	Mitogen
KW-0732	Signal
KW-0964	Secreted
KW-1015	Disulfide bond
KW-1185	Reference proteome