| Tag | Content |
|---|---|
| Uniprot ID | Q8CI19; Q99JM4; Q9JHV8; Q9QY71; |
| Entrez ID | 54635 |
| Genbank protein ID | AAH37696.1; BAC28455.1; BAC31358.1; AAH06027.1; AAK58566.1; BAC35216.1; AAF22516.1; AAF91483.1; |
| Genbank nucleotide ID | NM_019971.2 |
| Ensembl protein ID | ENSMUSP00000029652 |
| Ensembl nucleotide ID | ENSMUSG00000028019 |
| Gene name | Platelet-derived growth factor C |
| Gene symbol | Pdgfc |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5, E13.5 |
| Data sources | Manually collected |
| Reference | 17941048 |
| Functional description | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. |
| Sequence | MLLLGLLLLT SALAGQRTGT RAESNLSSKL QLSSDKEQNG VQDPRHERVV TISGNGSIHS 60 PKFPHTYPRN MVLVWRLVAV DENVRIQLTF DERFGLEDPE DDICKYDFVE VEEPSDGSVL 120 GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF PSEPGFCIHY SIIMPQVTET TSPSVLPPSS 180 LSLDLLNNAV TAFSTLEELI RYLEPDRWQV DLDSLYKPTW QLLGKAFLYG KKSKVVNLNL 240 LKEEVKLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK 300 VTKKYHEVLQ LRPKTGVKGL HKSLTDVALE HHEECDCVCR GNAGG 345 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFC | 102168934 | A0A452ET29 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFC | 100062015 | A0A3Q2HV05 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFC | 56034 | Q9NRA1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Pdgfc | 54635 | Q8CI19 | CPO | E12.5, E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFC | H2QQC3 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A481CL63 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | PDGFC | 100350272 | G1TDA1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Pdgfc | 79429 | Q9EQX6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pdgfc | 560564 | E7FB33 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005161 | platelet-derived growth factor receptor binding | ISO |
| GO:0005161 | platelet-derived growth factor receptor binding | IDA |
| GO:0005161 | platelet-derived growth factor receptor binding | IBA |
| GO:0008083 | growth factor activity | IEA |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0070851 | growth factor receptor binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | IDA |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008284 | positive regulation of cell population proliferation | IDA |
| GO:0008284 | positive regulation of cell population proliferation | IBA |
| GO:0009887 | animal organ morphogenesis | IGI |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | IBA |
| GO:0030335 | positive regulation of cell migration | IBA |
| GO:0031954 | positive regulation of protein autophosphorylation | IBA |
| GO:0043406 | positive regulation of MAP kinase activity | IBA |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | ISO |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IDA |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IBA |
| GO:0048146 | positive regulation of fibroblast proliferation | ISO |
| GO:0048565 | digestive tract development | IGI |
| GO:0048568 | embryonic organ development | IEA |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | IDA |
| GO:0051781 | positive regulation of cell division | IEA |
| GO:0060348 | bone development | IGI |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IBA |
| GO:0071230 | cellular response to amino acid stimulus | IDA |
| GO:0120162 | positive regulation of cold-induced thermogenesis | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IDA |
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IBA |
| GO:0005634 | nucleus | IEA |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0009986 | cell surface | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-186797 | Signaling by PDGF | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0339 | Growth factor |
| KW-0472 | Membrane |
| KW-0497 | Mitogen |
| KW-0539 | Nucleus |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0832 | Ubl conjugation |