| Tag | Content |
|---|---|
| Uniprot ID | Q9EQX6; Q8K429; |
| Entrez ID | 79429 |
| Genbank protein ID | AAM47265.1; BAB19969.1; |
| Genbank nucleotide ID | NM_031317.1 |
| Ensembl protein ID | ENSRNOP00000015081 |
| Ensembl nucleotide ID | ENSRNOG00000010695 |
| Gene name | Platelet-derived growth factor C |
| Gene symbol | Pdgfc |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function (By similarity). |
| Sequence | MLLLGLLLLT SALAGQRTGT RAESNLSSKL QLSSDKEQNG VQDPRHERVV TISGNGSIHS 60 PKFPHTYPRN TVLVWRLVAV DENVRIQLTF DERFGLEDPE DDLCKYDFVE VEEPSDGSVL 120 GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF PSEPGFCIHY SIIMPQVTET TSPSVLPPSA 180 LSLDLLNNAV TAFSTVEELI RFLEPDRWQI DLDSLYKPTW PLLGKAFLYG KKSKAVNLNL 240 LKEEVKLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK 300 VTKKYHEVLQ LRPKIGVKGL HKSLTDVALE HHEECDCVCR GNTEG 345 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFC | 102168934 | A0A452ET29 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFC | 100062015 | A0A3Q2HV05 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFC | 56034 | Q9NRA1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Pdgfc | 54635 | Q8CI19 | CPO | E12.5, E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFC | H2QQC3 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A481CL63 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | PDGFC | 100350272 | G1TDA1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Pdgfc | 79429 | Q9EQX6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pdgfc | 560564 | E7FB33 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005829 | cytosol |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0008083 | growth factor activity |
| GO:0070851 | growth factor receptor binding |
| GO:0005161 | platelet-derived growth factor receptor binding |
| GO:0042803 | protein homodimerization activity |
| GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity |
| GO:0009887 | animal organ morphogenesis |
| GO:0060348 | bone development |
| GO:0071230 | cellular response to amino acid stimulus |
| GO:0048565 | digestive tract development |
| GO:0048568 | embryonic organ development |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0051781 | positive regulation of cell division |
| GO:0030335 | positive regulation of cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0120162 | positive regulation of cold-induced thermogenesis |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| GO:0031954 | positive regulation of protein autophosphorylation |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0339 | Growth factor |
| KW-0472 | Membrane |
| KW-0497 | Mitogen |
| KW-0539 | Nucleus |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0832 | Ubl conjugation |