| Tag | Content |
|---|---|
| Uniprot ID | F6QG30 |
| Entrez ID | 100033848 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_014735870.1; XM_014735871.1; |
| Ensembl protein ID | ENSECAP00000015258 |
| Ensembl nucleotide ID | ENSECAG00000017112 |
| Gene name | Transporter |
| Gene symbol | SLC6A4 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | METTPLNSQK EPSACKDGED CQEDGVLQKG VPAPGDKAES GQISNGYSAV PSPGAGDDTQ 60 HSILAATTTL VAEVHQGERE TWGKKLDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP 120 YTVMAVFGGI PLFYMELALG QYHRNGCISI WRKVCPIFKG IGYAICVISF YIASYYNTIM 180 AWALYYLISS FTDQLPWTSC RNSWNTGNCT NYFSDDNITW TLHSKSPAEE FYTRHVLQVH 240 RSKGLQDLGG ISWQLALCIM LIFTIIYFSI WKGVKTSGKV VWVTATFPYV ILSVLLVRGA 300 TLPGAWRGVL FYLKPNWQKL LETGVWVDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 360 ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 420 TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHIWSQ RREWLVLGVV ITCFFGSLIT 480 LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVYWFYGITQ FCSDVKEMLG FSPGWFWRVC 540 WVAVSPLFLL FIICSFLMSP PQLRLFQYNY PHWSVVLGYC IGTSSFICIP TYITYRLIIT 600 PGTLKERIIK SITPETPTEI PCGDIRLNAI |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SLC6A4 | 491184 | F1PXA1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 102172383 | A0A452DQ43 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 100033848 | F6QG30 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 6532 | P31645 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Slc6a4 | 15567 | Q60857 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 468201 | A0A2J8LIN5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | G1SK44 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Slc6a4 | 25553 | P31652 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | slc6a4a | 664719 | Q1WGB5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0012505 | endomembrane system |
| GO:0005925 | focal adhesion |
| GO:0005887 | integral component of plasma membrane |
| GO:0045121 | membrane raft |
| GO:0043005 | neuron projection |
| GO:0005886 | plasma membrane |
| GO:0098793 | presynapse |
| GO:0050998 | nitric-oxide synthase binding |
| GO:0051378 | serotonin binding |
| GO:0005335 | serotonin:sodium symporter activity |
| GO:0048854 | brain morphogenesis |
| GO:0071310 | cellular response to organic substance |
| GO:0046621 | negative regulation of organ growth |
| GO:0045787 | positive regulation of cell cycle |
| GO:0010628 | positive regulation of gene expression |
| GO:0090067 | regulation of thalamus size |
| GO:0009636 | response to toxic substance |
| GO:0051610 | serotonin uptake |
| GO:0035176 | social behavior |