Gene: slc6a4a

Basic information

Tag Content
Uniprot ID Q1WGB5
Entrez ID 664719
Genbank protein ID ABB88575.1; AAI63766.1; AAI63777.1;
Genbank nucleotide ID XM_005157654.3; XM_009291668.2; XM_009291669.2; XM_009291671.2; XM_009291672.2; XM_005157655.3; XM_009291670.2; NM_001039972.1;
Ensembl protein ID ENSDARP00000081336
Ensembl nucleotide ID ENSDARG00000061165
Gene name Transporter
Gene symbol slc6a4a
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDMKESMMMN QEYGGEQQKV PESQENGRLV VDSVPEKDQK SGSGPGQVSN GYRSTSPQSP 60
KEGAGTGTDR VNTPGTFRTL VVQQTSLDPP RETWSKKMDF LLSVIGYAVD LGNVWRFPYI 120
CYQNGGGAFL LPYLLMAVFG GVPLFYMELA LGQFHRSGCI SIWKHVCPIF KGIGFAICII 180
ALYIAFYYNT IMAWALYYLL SSFRATLPWT TCNNRWNTPN CTHYLSTDLN VSWTNNSISP 240
AEEFYVRQVL QVHLSPGLHQ LGWVSWQLAL CLLFIFTVVY FSIWKGVKTS GKVVWVTATF 300
PYLVLLILLI RGATLPGAWR GVVFYLKPDW KKLLTTTVWL DAAAQIFFSL GPGFGVLLAF 360
ASYNPFHNNC YKDALITSSV NCLTSFLSGF VIFTVLGYMA EMRQQGVETV AKDAGPSLLF 420
IIYAEAIANM PAATFFAIIF FLMIIMLGLD STFAGLEGVI TAMLDEFPHL LARRREWFVL 480
GLVCVCYLGA LSTLTYGGAF VVKLFEEYAT GPAVITVVFL EVIAVSWFYG TTRFCNDVQL 540
MLGFAPGLFW RVCWIAICPC FLLFIIVSFL AFPPEVKLFD YLYPFWTTVL GYCIGVSSFI 600
CVPSYMVYHL VTTKGTFQQR LLKGITPEAP GSSGPQRDTI VITNAV 646

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSLC6A4491184F1PXA1Canis lupus familiarisPredictionMore>>
1:1 orthologSLC6A4102172383A0A452DQ43Capra hircusPredictionMore>>
1:1 orthologSLC6A4100033848F6QG30Equus caballusPredictionMore>>
1:1 orthologSLC6A46532P31645Homo sapiensPublicationMore>>
1:1 orthologSlc6a415567Q60857Mus musculusPredictionMore>>
1:1 orthologSLC6A4468201A0A2J8LIN5Pan troglodytesPredictionMore>>
1:1 orthologSLC6A4G1SK44Oryctolagus cuniculusPredictionMore>>
1:1 orthologSlc6a425553P31652Rattus norvegicusPredictionMore>>
1:1 orthologslc6a4a664719Q1WGB5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005887 integral component of plasma membrane
GO:0043005 neuron projection
GO:0098793 presynapse
GO:0051378 serotonin binding
GO:0005335 serotonin:sodium symporter activity
GO:0006837 serotonin transport
GO:0051610 serotonin uptake
GO:0035725 sodium ion transmembrane transport

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0472 Membrane
KW-1185 Reference proteome
KW-0769 Symport
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR000175 Na/ntran_symport
IPR037272 SNS_sf

PROSITE

PROSITE ID PROSITE Term
PS00610 NA_NEUROTRAN_SYMP_1
PS50267 NA_NEUROTRAN_SYMP_3

Pfam

Pfam ID Pfam Term
PF00209 SNF