| Tag | Content |
|---|---|
| Uniprot ID | P31652; P23976; |
| Entrez ID | 25553 |
| Genbank protein ID | AAA42186.1; CAA71909.1; CAA45401.1; CAA44913.1; |
| Genbank nucleotide ID | NM_013034.4; XM_017597042.1; XM_017597041.1; XM_017597043.1; XM_008767950.2; |
| Ensembl protein ID | ENSRNOP00000004717 |
| Ensembl nucleotide ID | ENSRNOG00000003476 |
| Gene name | Sodium-dependent serotonin transporter |
| Gene symbol | Slc6a4 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. |
| Sequence | METTPLNSQK VLSECKDRED CQENGVLQKG VPTTADRAEP SQISNGYSAV PSTSAGDEAS 60 HSIPAATTTL VAEIRQGERE TWGKKMDFLL SVIGYAVDLG NIWRFPYICY QNGGGAFLLP 120 YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTII 180 AWALYYLISS LTDRLPWTSC TNSWNTGNCT NYFAQDNITW TLHSTSPAEE FYLRHVLQIH 240 QSKGLQDLGT ISWQLTLCIV LIFTVIYFSI WKGVKTSGKV VWVTATFPYI VLSVLLVRGA 300 TLPGAWRGVV FYLKPNWQKL LETGVWVDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 360 ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 420 TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHIWAK RREWFVLIVV ITCVLGSLLT 480 LTSGGAYVVT LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCSDVKEMLG FSPGWFWRIC 540 WVAISPLFLL FIICSFLMSP PQLRLFQYNY PHWSIVLGYC IGMSSVICIP TYIIYRLIST 600 PGTLKERIIK SITPETPTEI PCGDIRMNAV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SLC6A4 | 491184 | F1PXA1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 102172383 | A0A452DQ43 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 100033848 | F6QG30 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 6532 | P31645 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Slc6a4 | 15567 | Q60857 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 468201 | A0A2J8LIN5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | G1SK44 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Slc6a4 | 25553 | P31652 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | slc6a4a | 664719 | Q1WGB5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0012505 | endomembrane system |
| GO:0010008 | endosome membrane |
| GO:0005925 | focal adhesion |
| GO:0099055 | integral component of postsynaptic membrane |
| GO:0099056 | integral component of presynaptic membrane |
| GO:0045121 | membrane raft |
| GO:0043005 | neuron projection |
| GO:0005886 | plasma membrane |
| GO:0099154 | serotonergic synapse |
| GO:0045202 | synapse |
| GO:0051015 | actin filament binding |
| GO:0019811 | cocaine binding |
| GO:0042802 | identical protein binding |
| GO:0046872 | metal ion binding |
| GO:0008504 | monoamine transmembrane transporter activity |
| GO:0050998 | nitric-oxide synthase binding |
| GO:0051378 | serotonin binding |
| GO:0005335 | serotonin:sodium symporter activity |
| GO:0017075 | syntaxin-1 binding |
| GO:0007420 | brain development |
| GO:0048854 | brain morphogenesis |
| GO:0071321 | cellular response to cGMP |
| GO:0071310 | cellular response to organic substance |
| GO:0071300 | cellular response to retinoic acid |
| GO:0007623 | circadian rhythm |
| GO:0007626 | locomotory behavior |
| GO:0007613 | memory |
| GO:0015844 | monoamine transport |
| GO:0021941 | negative regulation of cerebellar granule cell precursor proliferation |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0046621 | negative regulation of organ growth |
| GO:0032227 | negative regulation of synaptic transmission, dopaminergic |
| GO:0098810 | neurotransmitter reuptake |
| GO:0045787 | positive regulation of cell cycle |
| GO:0010628 | positive regulation of gene expression |
| GO:0014064 | positive regulation of serotonin secretion |
| GO:0090067 | regulation of thalamus size |
| GO:0042493 | response to drug |
| GO:0032355 | response to estradiol |
| GO:0001666 | response to hypoxia |
| GO:0007584 | response to nutrient |
| GO:0010033 | response to organic substance |
| GO:0009636 | response to toxic substance |
| GO:0006837 | serotonin transport |
| GO:0051610 | serotonin uptake |
| GO:0035176 | social behavior |
| GO:0042713 | sperm ejaculation |
| GO:0042310 | vasoconstriction |
| Keyword ID | Keyword Term |
|---|---|
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0532 | Neurotransmitter transport |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0915 | Sodium |
| KW-0769 | Symport |
| KW-0770 | Synapse |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0813 | Transport |