| Tag | Content |
|---|---|
| Uniprot ID | Q60857; O35241; Q5NCR6; |
| Entrez ID | 15567 |
| Genbank protein ID | CAA70092.1; AAA84750.1; AAB67172.1; |
| Genbank nucleotide ID | XM_006532301.3; XM_006532300.2; NM_010484.2; XM_006532299.2; |
| Ensembl protein ID | ENSMUSP00000104039; ENSMUSP00000021195; |
| Ensembl nucleotide ID | ENSMUSG00000020838 |
| Gene name | Sodium-dependent serotonin transporter |
| Gene symbol | Slc6a4 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. |
| Sequence | METTPLNSQK VLSECKDKED CQENGVLQKG VPTPADKAGP GQISNGYSAV PSTSAGDEAP 60 HSTPAATTTL VAEIHQGERE TWGKKMDFLL SVIGYAVDLG NIWRFPYICY QNGGGAFLLP 120 YTIMAIFGGI PLFYMELALG QYHRNGCISI WKKICPIFKG IGYAICIIAF YIASYYNTII 180 AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFAQDNITW TLHSTSPAEE FYLRHVLQIH 240 QSKGLQDLGT ISWQLALCIM LIFTIIYFSI WKGVKTSGKV VWVTATFPYI VLSVLLVRGA 300 TLPGAWRGVV FYLKPNWQKL LETGVWVDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 360 ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 420 TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHIWAK RREWFVLIVV ITCILGSLLT 480 LTSGGAYVVT LLEEYATGPA VLTVALIEAV VVSWFYGITQ FCSDVKEMLG FSPGWFWRIC 540 WVAISPLFLL FIICSFLMSP PQLRLFQYNY PHWSIILGYC IGTSSVICIP IYIIYRLIST 600 PGTLKERIIK SITPETPTEI PCGDIRMNAV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SLC6A4 | 491184 | F1PXA1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 102172383 | A0A452DQ43 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 100033848 | F6QG30 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 6532 | P31645 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Slc6a4 | 15567 | Q60857 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | 468201 | A0A2J8LIN5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SLC6A4 | G1SK44 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Slc6a4 | 25553 | P31652 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | slc6a4a | 664719 | Q1WGB5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005335 | serotonin:sodium symporter activity | ISO |
| GO:0005335 | serotonin:sodium symporter activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0008504 | monoamine transmembrane transporter activity | ISO |
| GO:0017075 | syntaxin-1 binding | ISO |
| GO:0019811 | cocaine binding | ISO |
| GO:0042802 | identical protein binding | ISS |
| GO:0042802 | identical protein binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GO:0050998 | nitric-oxide synthase binding | IPI |
| GO:0051015 | actin filament binding | ISS |
| GO:0051015 | actin filament binding | ISO |
| GO:0051378 | serotonin binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001666 | response to hypoxia | IEA |
| GO:0006837 | serotonin transport | ISO |
| GO:0006837 | serotonin transport | IMP |
| GO:0007584 | response to nutrient | IEA |
| GO:0007613 | memory | ISO |
| GO:0007623 | circadian rhythm | ISO |
| GO:0009636 | response to toxic substance | ISO |
| GO:0010628 | positive regulation of gene expression | IMP |
| GO:0014064 | positive regulation of serotonin secretion | ISO |
| GO:0015844 | monoamine transport | ISO |
| GO:0021941 | negative regulation of cerebellar granule cell precursor proliferation | ISO |
| GO:0032227 | negative regulation of synaptic transmission, dopaminergic | ISO |
| GO:0032355 | response to estradiol | IEA |
| GO:0035176 | social behavior | IGI |
| GO:0042310 | vasoconstriction | ISO |
| GO:0042493 | response to drug | IEA |
| GO:0042713 | sperm ejaculation | ISO |
| GO:0045665 | negative regulation of neuron differentiation | ISO |
| GO:0045787 | positive regulation of cell cycle | IMP |
| GO:0046621 | negative regulation of organ growth | IMP |
| GO:0048854 | brain morphogenesis | IMP |
| GO:0051259 | protein complex oligomerization | ISO |
| GO:0051260 | protein homooligomerization | ISO |
| GO:0051610 | serotonin uptake | ISO |
| GO:0051610 | serotonin uptake | IDA |
| GO:0051610 | serotonin uptake | IBA |
| GO:0051610 | serotonin uptake | IMP |
| GO:0055085 | transmembrane transport | IEA |
| GO:0071300 | cellular response to retinoic acid | IEA |
| GO:0071310 | cellular response to organic substance | IDA |
| GO:0071321 | cellular response to cGMP | ISO |
| GO:0090067 | regulation of thalamus size | ISS |
| GO:0090067 | regulation of thalamus size | ISO |
| GO:0098810 | neurotransmitter reuptake | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | ISS |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0005925 | focal adhesion | IDA |
| GO:0010008 | endosome membrane | IEA |
| GO:0012505 | endomembrane system | ISS |
| GO:0012505 | endomembrane system | ISO |
| GO:0043005 | neuron projection | ISO |
| GO:0043005 | neuron projection | IBA |
| GO:0045121 | membrane raft | ISO |
| GO:0045202 | synapse | IDA |
| GO:0099055 | integral component of postsynaptic membrane | ISO |
| GO:0099056 | integral component of presynaptic membrane | ISO |
| GO:0099154 | serotonergic synapse | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-112311 | Neurotransmitter clearance | IEA |
| R-MMU-112315 | Transmission across Chemical Synapses | IEA |
| R-MMU-112316 | Neuronal System | IEA |
| R-MMU-380615 | Serotonin clearance from the synaptic cleft | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0532 | Neurotransmitter transport |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0915 | Sodium |
| KW-0769 | Symport |
| KW-0770 | Synapse |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0813 | Transport |