Gene: ZIC3

Basic information

Tag Content
Uniprot ID G1TFC7
Entrez ID 100347605
Genbank protein ID
Genbank nucleotide ID XM_002720526.3
Ensembl protein ID ENSOCUP00000015617
Ensembl nucleotide ID ENSOCUG00000009358
Gene name Zic family member 3
Gene symbol ZIC3
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTMLLDGGPQ FPGLGVGSFG APRHHEMPNR ESAGMGLNPF GDSTHAAAAA AAAAAFKLSP 60
AAAHDLSSGQ SSAFTPQGSG YANALGHHHH HHHHHHHASQ VPSYGGAASA AFNSTRDFLF 120
RQRSSGLSEA ASGGGQHGLF AGSASSLHAP AGIPEPPGYL LFPGLHEQGA GHPSPTGHVD 180
NNQVHLGLRG DLFGRADPYR PVASPRADPY AASAQFPNYS PMNMNMGVNV AAHHGPGAFF 240
RYMRQPIKQE LSCKWIDEAQ LSRPKKSCDR TFSTMHELVT HVTMEHVGGP EQNNHVCYWE 300
ECPREGKSFK AKYKLVNHIR VHTGEKPFPC PFPGCGKIFA RSENLKIHKR THTGEKPFKC 360
EFEGCDRRFA NSSDRKKHMH VHTSDKPYIC KVCDKSYTHP SSLRKHMKVH ESQGSDSSPA 420
ASSGYESSTP PAIASANSKD TTKTPSAVQT STSHNPGLPP NFNEWYV 467

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologZIC3541035E1BJR9Bos taurusPredictionMore>>
1:1 orthologZIC3492171E2R969Canis lupus familiarisPredictionMore>>
1:1 orthologZIC3102177783A0A452FJL7Capra hircusPredictionMore>>
1:1 orthologZIC37547O60481Homo sapiensPredictionMore>>
1:1 orthologZic322773Q62521CPOMus musculusPublicationMore>>
1:1 orthologZIC3740302A0A2I3RP19Pan troglodytesPredictionMore>>
1:1 orthologZIC3100156863F1RQ88Sus scrofaPredictionMore>>
1:1 orthologZIC3100347605G1TFC7Oryctolagus cuniculusPredictionMore>>
1:1 orthologZic3367944A0A096MIX7Rattus norvegicusPredictionMore>>
1:1 orthologzic3368263Q6PV84Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005654 nucleoplasm
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0071907 determination of digestive tract left/right asymmetry
GO:0071910 determination of liver left/right asymmetry
GO:0035469 determination of pancreatic left/right asymmetry
GO:0001947 heart looping
GO:0030324 lung development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR041643 Znf_ZIC

PROSITE

PROSITE ID PROSITE Term
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00096 zf-C2H2
PF18366 zf_ZIC